Abstract：
:Imaging the human orbitofrontal cortex (OFC) with fMRI is problematic due to the proximity of this region to the air-filled sinuses, which causes susceptibility artifacts. Placing a strongly diamagnetic material into the mouth ('mouthshim') of a human volunteer can significantly reduce the artifacts in this region. Using the same combined olfactory and visual fMRI paradigm, we compared brain activation and static B0 field maps of participants being scanned both with and without the 'mouthshim'. Results demonstrate that the device improves the B0 field homogeneity within OFC, resulting in significantly stronger BOLD activation in this region. However, the device also caused both increased head motion and reduced activation in insular cortices due to more frequent swallowing and tactile stimulation of the tongue. The 'mouthshim' should only, therefore, be used where sensitivity in OFC regions is paramount.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Osterbauer RA,Wilson JL,Calvert GA,Jezzard Pdoi
10.1016/j.neuroimage.2005.07.006keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
245-53issue
1eissn
1053-8119issn
1095-9572pii
S1053-8119(05)00497-0journal_volume
29pub_type
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