Abstract：
:Contradictory reports regarding the detection of neuronal currents have left the feasibility of neuronal current MRI (ncMRI) an open question. Most previous ncMRI studies in human subjects are suspect due to their inability to separate or eliminate hemodynamic effects. In this study, we used a bloodless turtle brain preparation that eliminates hemodynamic effects, to explore the feasibility of detecting visually-evoked ncMRI signals at 9.4 T. Intact turtle brains, with eyes attached, were dissected from the cranium and placed in artificial cerebral spinal fluid. Light flashes were delivered to the eyes to evoke neuronal activity. Local field potential (LFP) and MRI signals were measured in an interleaved fashion. Robust visually-evoked LFP signals were observed in turtle brains, but no significant signal changes synchronized with neuronal currents were found in the ncMRI images. In this study, detection thresholds of 0.1% and 0.1 degrees were set for MRI magnitude and phase signal changes, respectively. The absence of significant signal changes in the MRI images suggests that visually-evoked ncMRI signals in the turtle brain are below these detectable levels.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Luo Q,Lu H,Lu H,Senseman D,Worsley K,Yang Y,Gao JHdoi
10.1016/j.neuroimage.2009.06.017subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1268-76issue
4eissn
1053-8119issn
1095-9572pii
S1053-8119(09)00631-4journal_volume
47pub_type
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