Abstract:
:Schizophrenia is associated with language-related dysfunction. A previous study [Schizophr. Res. 59 (2003c) 159] has shown that this abnormality is present at the level of automatic discrimination of change in speech sounds, as revealed by magnetoencephalographic recording of auditory mismatch field in response to across-category change in vowels. Here, we investigated the neuroanatomical substrate for this physiological abnormality. Thirteen patients with schizophrenia and 19 matched control subjects were examined using magnetoencephalography (MEG) and high-resolution magnetic resonance imaging (MRI) to evaluate both mismatch field strengths in response to change between vowel /a/ and /o/, and gray matter volumes of Heschl's gyrus (HG) and planum temporale (PT). The magnetic global field power of mismatch response to change in phonemes showed a bilateral reduction in patients with schizophrenia. The gray matter volume of left planum temporale, but not right planum temporale or bilateral Heschl's gyrus, was significantly smaller in patients with schizophrenia compared with that in control subjects. Furthermore, the phonetic mismatch strength in the left hemisphere was significantly correlated with left planum temporale gray matter volume in patients with schizophrenia only. These results suggest that structural abnormalities of the planum temporale may underlie the functional abnormalities of fundamental language-related processing in schizophrenia.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Yamasue H,Yamada H,Yumoto M,Kamio S,Kudo N,Uetsuki M,Abe O,Fukuda R,Aoki S,Ohtomo K,Iwanami A,Kato N,Kasai Kdoi
10.1016/j.neuroimage.2004.01.042keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
720-7issue
2eissn
1053-8119issn
1095-9572pii
S1053811904000874journal_volume
22pub_type
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