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The cortical cholinergic system contributes to the top-down control of distraction: Evidence from patients with Parkinson's disease.

Abstract：

:Past animal and human studies robustly report that the cholinergic system plays an essential role in both top-down and bottom-up attentional control, as well as other aspects of cognition (see Ballinger et al., 2016 for a recent review). However, current understanding of how two major cholinergic pathways in the human brain (the basal forebrain-cortical pathway, and the brainstem pedunculopontine-thalamic pathway) contribute to specific cognitive functions remains somewhat limited. To address this issue, we examine how individual variation in the integrity of striatal-dopaminergic, thalamic-cholinergic, and cortical-cholinergic pathways (measured using Positron Emission Tomography in patients with Parkinson's disease) was associated with individual variation in the initial goal-directed focus of attention, the ability to sustain attentional performance over time, and the ability to avoid distraction from a highly-salient, but irrelevant, environmental stimulus. Compared to healthy controls, PD patients performed similarly in the precision of attention-dependent judgments of duration, and in sustaining attention over time. However, PD patients' performance was strikingly more impaired by the distractor. More critically, regression analyses indicated that only cortical-cholinergic integrity, not thalamic-cholinergic or striatal-dopaminergic integrity, made a specific contribution to the ability to resist distraction after controlling for the other variables. These results demonstrate that the basal forebrain cortical cholinergic system serves a specific role in executing top-down control to resist external distraction.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Kim K,Müller MLTM,Bohnen NI,Sarter M,Lustig C

doi

10.1016/j.neuroimage.2017.12.012

subject

Has Abstract

pub_date

2019-04-15 00:00:00

pages

107-117

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(17)31026-1

journal_volume

190

pub_type

杂志文章

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