Abstract：
:Multi-echo T(2) relaxation decay data was acquired for 5 preadolescent males (age range 9-12 years). A signal to noise filter appropriate for multi-exponential T(2) analysis was then applied to remove voxels which did not accurately fit the modelled curve. The remaining voxels were designated "highly myelinated" if their myelin water fraction (MWF) was greater than a critical value. We investigated a range of signal to noise filter cut-off values and highly myelinated critical values and demonstrated a significant correlation (r=0.990, p<0.001) between verbal intelligence quotient scores on the Wechsler Intelligence Scale for Children - Revised and myelination of the corpus callosum in children. This relationship is supported by a growing number of studies showing a correlation between white matter development and cognitive ability.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Whitaker KJ,Kolind SH,MacKay AL,Clark CMdoi
10.1016/j.neuroimage.2008.07.038subject
Has Abstractpub_date
2008-12-01 00:00:00pages
731-5issue
4eissn
1053-8119issn
1095-9572pii
S1053-8119(08)00859-8journal_volume
43pub_type
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