Abstract：
:Functional lateralization is a feature of human brain function, most apparent in the typical left-hemisphere specialization for language. A number of anatomical and imaging studies have examined whether structural asymmetries underlie this functional lateralization. We combined functional MRI (fMRI) and diffusion-weighted imaging (DWI) with tractography to study 10 healthy right-handed subjects. Three language fMRI paradigms were used to define language-related regions in inferior frontal and superior temporal regions. A probabilistic tractography technique was then employed to delineate the connections of these functionally defined regions. We demonstrated consistent connections between Broca's and Wernicke's areas along the superior longitudinal fasciculus bilaterally but more extensive fronto-temporal connectivity on the left than the right. Both tract volumes and mean fractional anisotropy (FA) were significantly greater on the left than the right. We also demonstrated a correlation between measures of structure and function, with subjects with more lateralized fMRI activation having a more highly lateralized mean FA of their connections. These structural asymmetries are in keeping with the lateralization of language function and indicate the major structural connections underlying this function.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Powell HW,Parker GJ,Alexander DC,Symms MR,Boulby PA,Wheeler-Kingshott CA,Barker GJ,Noppeney U,Koepp MJ,Duncan JSdoi
10.1016/j.neuroimage.2006.03.011subject
Has Abstractpub_date
2006-08-01 00:00:00pages
388-99issue
1eissn
1053-8119issn
1095-9572pii
S1053-8119(06)00176-5journal_volume
32pub_type
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