Abstract：
:Working memory is a fundamental cognitive building block involved in the short-term maintenance and transformation of information. In neuropsychological studies, working memory has been shown to be of limited capacity; however, the neurophysiological concomitants of this capacity limitation have not been explored. In this study we used the [15O] water PET rCBF technique and statistical parametric mapping to examine normal subjects while they performed two cognitive tasks, both individually and simultaneously. One task was the Wisconsin Card Sorting Test, a complex reasoning task involving working memory, and the other was a rapidly paced auditory verbal shadowing task. When both tasks were performed simultaneously, there were significant decrements in performance compared with the individual task performance scores, indicating that cognitive workload had been increased. Analysis of the rCBF maps showed that when the two tasks were performed together, in contrast to when they were performed separately, there was less prefrontal activation. These results suggest that increases in cognitive workload do not necessarily recruit and then sustain cortical neurophysiological resources to a maximum, but rather may actually be accompanied by a diminution in cortical activity.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Goldberg TE,Berman KF,Fleming K,Ostrem J,Van Horn JD,Esposito G,Mattay VS,Gold JM,Weinberger DRdoi
10.1006/nimg.1998.0338subject
Has Abstractpub_date
1998-05-01 00:00:00pages
296-303issue
4 Pt 1eissn
1053-8119issn
1095-9572pii
S1053-8119(98)90338-Xjournal_volume
7pub_type
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