Abstract:
:In this fMRI study, we investigated the convergence of underlying neural networks in thinking about a scenario involving one's own intentional action and its consequences and setting up and holding in mind an intention to act. A factorial design was employed comprising two factors: i. Causality (intentional or physical events) and ii. Prospective Memory (present or absent). In each condition, subjects answered questions about various hypothetical scenarios, which related either to the link between the subject's own intentions and consequential actions (Intentional Causality) or to the link between a natural, physical event and its consequences (Physical Causality). A prospective memory task was embedded in half the blocks. In this task, subjects were required to keep in mind an intention (to press a key on seeing a red stimulus background) whilst carrying out the ongoing Causality task. Answering questions about intentional causality versus physical causality activated a network of regions that have traditionally been associated with Theory of Mind, including the medial prefrontal cortex (mPFC), the superior temporal sulcus and the temporal poles bilaterally. In addition, the precuneus bordering with posterior cingulate cortex, an area involved in self-awareness and self-related processing, was activated more when thinking about intentional causality. In the prospective memory task, activations were found in the right parietal cortex, frontopolar cortex (BA 10) and precuneus. Different subregions within the precuneus/posterior cingulate cortex were activated in both main effects of intentional causality and prospective memory. Therefore, the precuneus/posterior cingulate cortex subserves separately thinking about one's own intentions and consequent actions and bearing in mind an intention to make an action. Previous studies have shown that prospective memory, requiring the formation of an intention and the execution of a corresponding action, is associated with decreased activation in the dorsal mPFC, close to the region activated in Theory of Mind tasks. Here, we found that holding in mind an intention to act and at the same time thinking about an intentional action led to reduced activity in a dorsal section of the mPFC. This was a different region from a more anterior, inferior dorsal mPFC region that responded to intentional causality. This suggests that different regions of mPFC play different roles in thinking about intentions.
journal_name
Neuroimagejournal_title
NeuroImageauthors
den Ouden HE,Frith U,Frith C,Blakemore SJdoi
10.1016/j.neuroimage.2005.05.001keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
787-96issue
4eissn
1053-8119issn
1095-9572pii
S1053-8119(05)00310-1journal_volume
28pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract::Functional positron emission tomography (fPET) is a neuroimaging method involving continuous infusion of 18-F-fluorodeoxyglucose (FDG) radiotracer during the course of a PET examination. Compared with the conventional bolus administration of FDG in a static PET scan, which provides an average glucose uptake into the b...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.116720
更新日期:2020-06-01 00:00:00
abstract::Cognition that is not based on perception can lead to at least two different outcomes. In some situations, cognition that is independent of perception can allow actions to be selected other than those prescribed by immediate perceptual input. In others, cognition can be independent of perception and unrelated to the c...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.12.012
更新日期:2013-04-01 00:00:00
abstract::This paper reviews and compares individual voxel-wise thresholding methods for identifying active voxels in single-subject fMRI datasets. Different error rates are described which may be used to calibrate activation thresholds. We discuss methods which control each of the error rates at a prespecified level alpha, inc...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2003.12.047
更新日期:2004-05-01 00:00:00
abstract::This paper formulates a novel probabilistic graphical model for noisy stimulus-evoked MEG and EEG sensor data obtained in the presence of large background brain activity. The model describes the observed data in terms of unobserved evoked and background factors with additive sensor noise. We present an expectation max...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2005.09.055
更新日期:2006-04-01 00:00:00
abstract::Brain-computer interfaces (BCIs) have been largely developed to allow communication, control, and neurofeedback in human beings. Despite their great potential, BCIs perform inconsistently across individuals and the neural processes that enable humans to achieve good control remain poorly understood. To address this qu...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116500
更新日期:2020-04-01 00:00:00
abstract::Diffusion tensor MRI is sensitive to the coherent structure of brain tissue and is commonly used to study large-scale white matter structure. Diffusion in gray matter is more isotropic, however, several groups have observed coherent patterns of diffusion anisotropy within the cerebral cortical gray matter. We extend t...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.11.065
更新日期:2013-04-01 00:00:00
abstract::Local moment-to-moment variability exists at every level of neural organization, but its driving forces remain opaque. Inspired by animal work demonstrating that local temporal variability may reflect synaptic input rather than locally-generated "noise," we used publicly-available high-temporal-resolution fMRI data (N...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.08.019
更新日期:2018-12-01 00:00:00
abstract::Due to the physiological coupling with metabolism, brain perfusion is a potential aid in understanding the effects of medication on neural activity in vivo. In this study, arterial spin labeling (ASL) was used to quantify the effect of seven days of administration of paroxetine (20 mg), bupropion (150 mg) on cerebral ...
journal_title:NeuroImage
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neuroimage.2012.03.014
更新日期:2012-07-16 00:00:00
abstract::We demonstrate the capacity of dynamic causal modeling to characterize the nonlinear coupling among cortical sources that underlie time-frequency modulations in MEG data. Our experimental task involved the mental rotation of hand drawings that ten subjects used to decide if it was a right or left hand. Reaction times ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.12.076
更新日期:2013-05-01 00:00:00
abstract::Although numbers carry averbal semantics (i.e., magnitude), they are often utilized in verbal Working Memory (vWM) tasks. However, vWM is thought to rely on a purely phonological code. Here, we tested the influence of (a) averbal semantics and (b) different tasks on performance in a vWM context by examining stimulus a...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroimage.2005.07.009
更新日期:2006-01-01 00:00:00
abstract::Statistical analysis on arbitrary surface meshes such as the cortical surface is an important approach to understanding brain diseases such as Alzheimer's disease (AD). Surface analysis may be able to identify specific cortical patterns that relate to certain disease characteristics or exhibit differences between grou...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.02.028
更新日期:2014-06-01 00:00:00
abstract::Stimulation of acupuncture point Pc6, located above the median nerve, has been shown to be effective in treating nausea and vomiting. It has also frequently been reported to cause a heart rate reduction. The mechanism behind this autonomic reaction has not been clarified, so far. We combined brainstem-sensitive functi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.12.045
更新日期:2012-03-01 00:00:00
abstract::Cerebral artery segmentation plays an important role in the direct visualization of the human brain to obtain vascular system information. On ultra-high field magnetic resonance imaging, cerebral arteries appearing hyperintense on T1 weighted (T1w) images could be segmented from brain tissues such as gray and white ma...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117259
更新日期:2020-11-15 00:00:00
abstract::Functional ultrasound imaging is a method recently developed to assess brain activity via hemodynamics in rodents. Doppler ultrasound signals allow the measurement of cerebral blood volume (CBV) and red blood cells' (RBCs') velocity in small vessels. However, this technique originally requires performing a large crani...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.06.063
更新日期:2014-11-01 00:00:00
abstract::The ability to select and integrate relevant information in the presence of competing irrelevant information can be enhanced by advance information to direct attention and guide response selection. Attentional preparation can reduce perceptual and response conflict, yet little is known about the neural source of confl...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.06.058
更新日期:2009-11-01 00:00:00
abstract::Classic identity negative priming (NP) refers to the finding that when an object is ignored, subsequent naming responses to it are slower than when it has not been previously ignored (Tipper, S.P., 1985. The negative priming effect: inhibitory priming by ignored objects. Q. J. Exp. Psychol. 37A, 571-590). It is unclea...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroimage.2006.06.024
更新日期:2006-10-15 00:00:00
abstract::In the General Linear Model (GLM) framework for the statistical analysis of fMRI data, the problem of temporal autocorrelations in the residual signal (after regression) has been frequently addressed in the open literature. There exist various methods for correcting the ensuing bias in the statistical testing, among w...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.07.048
更新日期:2004-11-01 00:00:00
abstract::A major determinant of multisensory integration, derived from single-neuron studies in animals, is the principle of inverse effectiveness (IE), which describes the phenomenon whereby maximal multisensory response enhancements occur when the constituent unisensory stimuli are minimally effective in evoking responses. H...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.03.075
更新日期:2011-06-15 00:00:00
abstract::Human depression, for which chronic psychosocial stress is a major risk factor, is characterized by consistent alterations in neurocircuitry. For example, there is increased functional connectivity (FC) within and between regions comprising the default mode network (DMN) including prefrontal cortex and cingulate corte...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.08.013
更新日期:2016-11-15 00:00:00
abstract::This article reviews studies demonstrating enhancement with transcranial direct current stimulation (tDCS) of attention, learning, and memory processes in healthy adults. Given that these are fundamental cognitive functions, they may also mediate stimulation effects on other higher-order processes such as decision-mak...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2013.07.083
更新日期:2014-01-15 00:00:00
abstract:BACKGROUND:Mesial temporal lobe epilepsy (mTLE) with hippocampus sclerosis (HS) is an important cause for focal epilepsy. In this study, we explored the integrity of connecting networks using diffusion tensor imaging (DTI) and two whole-brain voxel-based methods: statistical parametric mapping (SPM) and tract-based spa...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.12.031
更新日期:2008-04-01 00:00:00
abstract::Humans exhibit a marked specialization to process the most experienced facial morphologies. In particular, nonhuman primate faces are poorly discriminated compared to human faces in behavioral tasks. So far however, a clear and consistent marker that quantifies our expertise in human over monkey face discrimination di...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116218
更新日期:2020-01-01 00:00:00
abstract::There is a pressing need for new therapeutic, diagnostic, and drug delivery approaches for treating brain cancers. Nanotechnology offers a new method for targeted brain cancer therapy and could play a major role in gene and drug delivery. The goals of our study were to visualize in vitro ingestion, cytotoxicity, and l...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.03.078
更新日期:2007-01-01 00:00:00
abstract::Stress resilience is mediated, in part, by our ability to predict and control threats within our environment. Therefore, determining the neural mechanisms that regulate the emotional response to predictable and controllable threats may provide important new insight into the processes that mediate resilience to emotion...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.06.086
更新日期:2015-10-01 00:00:00
abstract::Owing to its intrinsic characteristics, spatiotemporally encoded (SPEN) imaging is less sensitive to adverse effects due to field inhomogeneity in comparison with echo planar imaging, a feature highly desired for functional, diffusion, and real-time MRI. However, the quality of images obtained with SPEN MRI is still d...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.10.041
更新日期:2015-01-15 00:00:00
abstract::Visual information processing involves the integration of stimulus and goal-driven information, requiring neuronal communication. Gamma synchronisation is linked to neuronal communication, and is known to be modulated in visual cortex both by stimulus properties and voluntarily-directed attention. Stimulus-driven modu...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.04.108
更新日期:2013-10-01 00:00:00
abstract::Use and non-use of body parts during goal-directed action are major forces driving reorganisation of neural processing. We investigated changes in functional brain activity resulting from acute short-term immobilisation of the dominant right hand. Informed by the concept of object affordances, we predicted that the pr...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.02.003
更新日期:2014-05-15 00:00:00
abstract::This study investigates word and object processing during naming and viewing tasks and identifies three distinct regions in the left ventral occipitotemporal cortex. Irrespective of task, words and objects (relative to meaningless visual controls) activated the medial surface of the left anterior fusiform gyrus, a reg...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1006/nimg.1999.0450
更新日期:1999-08-01 00:00:00
abstract::Functional localizers are routinely used in neuroimaging studies to test hypotheses about the function of specific brain areas. The specific tasks and stimuli used to localize particular regions vary widely from study to study even when the same cortical region is targeted. Thus, it is important to ask whether task an...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2009.12.024
更新日期:2010-03-01 00:00:00
abstract::Human communication and survival depend on effective social information processing. Abundant behavioral evidence has shown that humans efficiently judge preferences for other individuals, a critical task in social interaction, yet the neural mechanism of this basic social evaluation, remains less than clear. Using a s...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.02.044
更新日期:2010-06-01 00:00:00