当前位置： SCI文献检索 > NEUROIMAGE期刊下所有文献 > Imaging brain amyloid deposition using grating-based differential phase contrast tomography.

Imaging brain amyloid deposition using grating-based differential phase contrast tomography.

Abstract：

:One of the core pathological features of Alzheimer's disease (AD) is the accumulation of amyloid plaques in the brain. Current efforts of medical imaging research aim at visualizing amyloid plaques in living patients in order to evaluate the progression of the pathology, but also to facilitate the diagnosis of AD at the prodromal stage. In this study, we evaluated the capabilities of a new experimental imaging setup to image amyloid plaques in the brain of a transgenic mouse model of Alzheimer's disease. This imaging setup relies on a grating interferometer at a synchrotron X-ray source to measure the differential phase contrast between brain tissue and amyloid plaques. It provides high-resolution images with a large field of view, making it possible to scan an entire mouse brain. Here, we showed that this setup yields sufficient contrast to detect amyloid plaques and to quantify automatically several important structural parameters, such as their size and their regional density in 3D, on the scale of a whole mouse brain. Whilst future developments are required to apply this technique in vivo, this grating-based setup already gives the possibility to perform powerful studies aiming at quantifying the amyloid pathology in mouse models of AD and might accelerate the evaluation of anti-amyloid compounds. In addition, this technique may also facilitate the development of other amyloid imaging methods such as positron emission tomography (PET) by providing convenient high-resolution 3D data of the plaque distribution for multimodal comparison.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Pinzer BR,Cacquevel M,Modregger P,McDonald SA,Bensadoun JC,Thuering T,Aebischer P,Stampanoni M

doi

10.1016/j.neuroimage.2012.03.029

subject

Has Abstract

pub_date

2012-07-16 00:00:00

pages

1336-46

issue

4

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(12)00302-3

journal_volume

61

pub_type

杂志文章

相关文献

NEUROIMAGE文献大全
  • Gastric fundic distension activates fronto-limbic structures but not primary somatosensory cortex: a functional magnetic resonance imaging study.

    abstract：INTRODUCTION:The brain representation of visceral stimulation bears important similarities to that of somatic stimulation. However, the role of the primary (S1) and secondary (S2) somatosensory cortices in mediating gastric sensation is uncertain. MATERIALS AND METHODS:Eighteen healthy, right-handed volunteers (age 32...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.07.033

    authors： Ladabaum U,Roberts TP,McGonigle DJ

    更新日期：2007-01-15 00:00:00

  • Cortical dynamics during preparation and execution of reactive balance responses with distinct postural demands.

    abstract：:The contributions of the cerebral cortex to human balance control are clearly demonstrated by the profound impact of cortical lesions on the ability to maintain standing balance. The cerebral cortex is thought to regulate subcortical postural centers to maintain upright balance and posture under varying environmental ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.12.045

    authors： Solis-Escalante T,van der Cruijsen J,de Kam D,van Kordelaar J,Weerdesteyn V,Schouten AC

    更新日期：2019-03-01 00:00:00

  • BOLD correlates of EMG spectral density in cortical myoclonus: description of method and case report.

    abstract：:The recording of electrophysiological data during BOLD fMRI is highly challenging but provides the opportunity to develop a more thorough account of brain function than either modality alone. To develop new techniques in this area has often required the study of pathological electrophysiological measures because such ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.04.183

    authors： Richardson MP,Grosse P,Allen PJ,Turner R,Brown P

    更新日期：2006-08-15 00:00:00

  • Specialization within the ventral stream: the case for the visual word form area.

    abstract：:Is there specialization for visual word recognition within the visual ventral stream of literate human adults? We review the evidence for a specialized "visual word form area" and critically examine some of the arguments recently placed against this hypothesis. Three distinct forms of specialization must be distinguis...

    journal_title：NeuroImage

    pub_type： 信件

    doi：10.1016/j.neuroimage.2003.12.049

    authors： Cohen L,Dehaene S

    更新日期：2004-05-01 00:00:00

  • Problem solving, working memory, and motor correlates of association and commissural fiber bundles in normal aging: a quantitative fiber tracking study.

    abstract：:Normal aging is accompanied by decline in selective cognitive and motor functions. A concurrent decline in regional white matter integrity, detectable with diffusion tensor imaging (DTI), potentially contributes to waning function. DTI analysis of white matter loci indicates an anterior-to-posterior gradient distribut...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2008.09.046

    authors： Zahr NM,Rohlfing T,Pfefferbaum A,Sullivan EV

    更新日期：2009-02-01 00:00:00

  • An approach to high resolution diffusion tensor imaging in fixed primate brain.

    abstract：:High resolution ex vivo diffusion tensor imaging (DTI) studies of neural tissues can improve our understanding of brain structure. In these studies we can modify the tissue relaxation properties of the fixed tissues to better suite the scanner hardware. We investigated the use of Gd-DTPA contrast agent to provide the ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.12.028

    authors： D'Arceuil HE,Westmoreland S,de Crespigny AJ

    更新日期：2007-04-01 00:00:00

  • Myelination and long diffusion times alter diffusion-tensor-imaging contrast in myelin-deficient shiverer mice.

    abstract：:Diffusion tensor imaging (DTI) using variable diffusion times (t(diff)) was performed to investigate wild-type (wt) mice, myelin-deficient shiverer (shi) mutant mice and shi mice transplanted with wt neural precursor cells that differentiate and function as oligodendrocytes. At t(diff) = 30 ms, the diffusion anisotrop...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2005.05.049

    authors： Nair G,Tanahashi Y,Low HP,Billings-Gagliardi S,Schwartz WJ,Duong TQ

    更新日期：2005-10-15 00:00:00

  • Cortical reactivations during sleep spindles following declarative learning.

    abstract：:Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2019.03.051

    authors： Jegou A,Schabus M,Gosseries O,Dahmen B,Albouy G,Desseilles M,Sterpenich V,Phillips C,Maquet P,Grova C,Dang-Vu TT

    更新日期：2019-07-15 00:00:00

  • Regionconnect: Rapidly extracting standardized brain connectivity information in voxel-wise neuroimaging studies.

    abstract：:Reporting white matter findings in voxel-wise neuroimaging studies typically lacks specificity in terms of brain connectivity. Therefore, the purpose of this work was to develop an approach for rapidly extracting standardized brain connectivity information for white matter regions with significant findings in voxel-wi...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2020.117462

    authors： Qi X,Arfanakis K

    更新日期：2021-01-15 00:00:00

  • Measuring temporal dynamics of functional networks using phase spectrum of fMRI data.

    abstract：:We present a novel method to measure relative latencies between functionally connected regions using phase-delay of functional magnetic resonance imaging data. Derived from the phase component of coherency, this quantity estimates the linear delay between two time-series. In conjunction with coherence, derived from th...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2005.05.043

    authors： Sun FT,Miller LM,D'Esposito M

    更新日期：2005-10-15 00:00:00

  • Structural brain variation and general intelligence.

    abstract：:Total brain volume accounts for about 16% of the variance in general intelligence scores (IQ), but how volumes of specific regions-of-interest (ROIs) relate to IQ is not known. We used voxel-based morphometry (VBM) in two independent samples to identify substantial gray matter (GM) correlates of IQ. Based on statistic...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2004.04.025

    authors： Haier RJ,Jung RE,Yeo RA,Head K,Alkire MT

    更新日期：2004-09-01 00:00:00

  • Where syntax meets math: right intraparietal sulcus activation in response to grammatical number agreement violations.

    abstract：:Previous research has shown that the processing of words referring to actions activated motor areas. Here, we show activation of the right intraparietal sulcus, an area that has been associated with quantity processing, when participants are asked to read pairs of words with number agreement violations as opposed to p...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.09.058

    authors： Carreiras M,Carr L,Barber HA,Hernandez A

    更新日期：2010-01-15 00:00:00

  • Functional imaging of visuospatial processing in Alzheimer's disease.

    abstract：:Alzheimer's disease (AD) is known to cause a variety of disturbances of higher visual functions that are closely related to the neuropathological changes. Visual association areas are more affected than primary visual cortex. Additionally, there is evidence from neuropsychological and imaging studies during rest or pa...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1006/nimg.2002.1271

    authors： Prvulovic D,Hubl D,Sack AT,Melillo L,Maurer K,Frölich L,Lanfermann H,Zanella FE,Goebel R,Linden DE,Dierks T

    更新日期：2002-11-01 00:00:00

  • Dynamic neuroimaging of retinal light responses using fast intrinsic optical signals.

    abstract：:Transient intrinsic optical responses associated with neural activation offer an attractive strategy for dynamic imaging of neural activity, and may provide a noninvasive methodology for imaging of retinal function. Here we demonstrate the feasibility of near infrared imaging of fast intrinsic optical changes in isola...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.06.060

    authors： Yao XC,George JS

    更新日期：2006-11-15 00:00:00

  • Segmentation of the mouse hippocampal formation in magnetic resonance images.

    abstract：:The hippocampal formation plays an important role in cognition, spatial navigation, learning, and memory. High resolution magnetic resonance (MR) imaging makes it possible to study in vivo changes in the hippocampus over time and is useful for comparing hippocampal volume and structure in wild type and mutant mice. Su...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.06.025

    authors： Richards K,Watson C,Buckley RF,Kurniawan ND,Yang Z,Keller MD,Beare R,Bartlett PF,Egan GF,Galloway GJ,Paxinos G,Petrou S,Reutens DC

    更新日期：2011-10-01 00:00:00

  • Supervisory experience at work is linked to low rate of hippocampal atrophy in late life.

    abstract：:Cultivation of an active cognitive lifestyle, including diverse and challenging educational, occupational and cognitively-loaded leisure activities may be protective against development of dementia but the mechanisms underlying this link are not clear. We used the Lifetime Experiences Questionnaire (LEQ) to assess the...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2012.08.015

    authors： Suo C,León I,Brodaty H,Trollor J,Wen W,Sachdev P,Valenzuela MJ

    更新日期：2012-11-15 00:00:00

  • Local linear discriminant analysis (LLDA) for group and region of interest (ROI)-based fMRI analysis.

    abstract：:A post-processing method for group discriminant analysis of fMRI is proposed. It assumes that the fMRI data have been pre-processed and analyzed so that each voxel is given a statistic specifying task-related activation(s), and that individually specific regions of interest (ROIs) have been drawn for each subject. The...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.04.072

    authors： McKeown MJ,Li J,Huang X,Lewis MM,Rhee S,Young Truong KN,Wang ZJ

    更新日期：2007-09-01 00:00:00

  • Resting-state networks predict individual differences in common and specific aspects of executive function.

    abstract：:The goal of the present study was to examine relationships between individual differences in resting state functional connectivity as ascertained by fMRI (rs-fcMRI) and performance on tasks of executive function (EF), broadly defined as the ability to regulate thoughts and actions. Unlike most previous research that f...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2014.09.045

    authors： Reineberg AE,Andrews-Hanna JR,Depue BE,Friedman NP,Banich MT

    更新日期：2015-01-01 00:00:00

  • Neural circuitry underlying sentence-level linguistic prosody.

    abstract：:This study investigates the neural substrates underlying the perception of two sentence-level prosodic phenomena in Mandarin Chinese: contrastive stress (initial vs. final emphasis position) and intonation (declarative vs. interrogative modality). In an fMRI experiment, Chinese and English listeners were asked to sele...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.neuroimage.2005.06.002

    authors： Tong Y,Gandour J,Talavage T,Wong D,Dzemidzic M,Xu Y,Li X,Lowe M

    更新日期：2005-11-01 00:00:00

  • Contribution of chronic pain and neuroticism to abnormal forebrain gray matter in patients with temporomandibular disorder.

    abstract：:Cortical plasticity is thought to occur following continuous barrage of nociceptive afferent signals to the brain. Hence, chronic pain is presumed to induce anatomical and physiological changes in the brain over time. Inherent factors, some pre-dating the onset of chronic pain, may also contribute to brain abnormaliti...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.12.013

    authors： Moayedi M,Weissman-Fogel I,Crawley AP,Goldberg MB,Freeman BV,Tenenbaum HC,Davis KD

    更新日期：2011-03-01 00:00:00

  • Gender identity better than sex explains individual differences in episodic and semantic components of autobiographical memory: An fMRI study.

    abstract：:Advances in the literature of sex-related differences in autobiographical memory increasingly tend to highlight the importance of psychosocial factors such as gender identity, which may explain these differences better than sex as a biological factor. To date, however, none of these behavioral studies have investigate...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2020.117507

    authors： Compère L,Charron S,Gallarda T,Rari E,Lion S,Nys M,Anssens A,Coussinoux S,Machefaux S,Oppenheim C,Piolino P

    更新日期：2021-01-15 00:00:00

  • Task-dependent modulation of the visual sensory thalamus assists visual-speech recognition.

    abstract：:The cerebral cortex modulates early sensory processing via feed-back connections to sensory pathway nuclei. The functions of this top-down modulation for human behavior are poorly understood. Here, we show that top-down modulation of the visual sensory thalamus (the lateral geniculate body, LGN) is involved in visual-...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.05.032

    authors： Díaz B,Blank H,von Kriegstein K

    更新日期：2018-09-01 00:00:00

  • Sex differences in the neural correlates of child facial resemblance: an event-related fMRI study.

    abstract：:Detection of genetic relatedness (i.e. kinship) impacts the social, parental, and sexual behavior of many species. In humans, self-referent phenotype matching based on facial resemblance may indicate kinship. For example, faces that resemble ours are perceived as more trustworthy and attractive. Sex differences in beh...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.neuroimage.2004.12.037

    authors： Platek SM,Keenan JP,Mohamed FB

    更新日期：2005-05-01 00:00:00

  • Grasping with a new hand: Improved performance and normalized grasp-selective brain responses despite persistent functional changes in primary motor cortex and low-level sensory and motor impairments.

    abstract：:Hand loss can now be reversed through surgical transplantation years or decades after amputation. Remarkably, these patients come to use their new hand to skilfully grasp and manipulate objects. The brain mechanisms that make this possible are unknown. Here we test the hypothesis that the anterior intraparietal cortex...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.09.052

    authors： Valyear KF,Mattos D,Philip BA,Kaufman C,Frey SH

    更新日期：2019-04-15 00:00:00

  • Stereomotion processing in the human occipital cortex.

    abstract：:Although a high proportion of the motion selective cells in primate motion area, MT, are disparity-selective, there is no convincing evidence for cells in this area specific to stereomotion-in-depth and the neural basis of stereomotion processing remains obscure. With functional magnetic resonance imaging (fMRI), we i...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.06.039

    authors： Likova LT,Tyler CW

    更新日期：2007-11-01 00:00:00

  • Characterizing function-structure relationships in the human visual system with functional MRI and diffusion tensor imaging.

    abstract：:A key objective in neuroscience is to improve our understanding of the relationship between brain function and structure. We investigated this in the posterior visual pathways of healthy volunteers by applying functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) with tractography. The optic ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2003.11.022

    authors： Toosy AT,Ciccarelli O,Parker GJ,Wheeler-Kingshott CA,Miller DH,Thompson AJ

    更新日期：2004-04-01 00:00:00

  • Distant from input: Evidence of regions within the default mode network supporting perceptually-decoupled and conceptually-guided cognition.

    abstract：:The default mode network supports a variety of mental operations such as semantic processing, episodic memory retrieval, mental time travel and mind-wandering, yet the commonalities between these functions remains unclear. One possibility is that this system supports cognition that is independent of the immediate envi...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.01.017

    authors： Murphy C,Jefferies E,Rueschemeyer SA,Sormaz M,Wang HT,Margulies DS,Smallwood J

    更新日期：2018-05-01 00:00:00

  • Segregation of visceral and somatosensory afferents: an fMRI and cytoarchitectonic mapping study.

    abstract：:Ano-rectal stimulation provides an important model for the processing of somatosensory and visceral sensations in the human nervous system. In spite of their anatomical proximity, the anal canal is innervated by somatosensory afferents whereas the rectum is innervated by the visceral nervous system. In a functional ma...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.01.023

    authors： Eickhoff SB,Lotze M,Wietek B,Amunts K,Enck P,Zilles K

    更新日期：2006-07-01 00:00:00

  • Inter-individual differences in trait anxiety shape the functional connectivity between the bed nucleus of the stria terminalis and the amygdala during brief threat processing.

    abstract：:An influential framework suggests that the central nucleus of the amygdala (CeA) is involved in phasic responses to threat, while the bed nucleus of the stria terminalis (BNST) mediates sustained anxiety. However, this model has been questioned, proposing that the role of the BNST is not limited to sustained threat co...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.10.054

    authors： Brinkmann L,Buff C,Feldker K,Neumeister P,Heitmann CY,Hofmann D,Bruchmann M,Herrmann MJ,Straube T

    更新日期：2018-02-01 00:00:00

  • Self-referential processing in our brain--a meta-analysis of imaging studies on the self.

    abstract：:The question of the self has intrigued philosophers and psychologists for a long time. More recently, distinct concepts of self have also been suggested in neuroscience. However, the exact relationship between these concepts and neural processing across different brain regions remains unclear. This article reviews neu...

    journal_title：NeuroImage

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.neuroimage.2005.12.002

    authors： Northoff G,Heinzel A,de Greck M,Bermpohl F,Dobrowolny H,Panksepp J

    更新日期：2006-05-15 00:00:00