当前位置： SCI文献检索 > NEUROIMAGE期刊下所有文献 > Functional imaging of visuospatial processing in Alzheimer's disease.

Functional imaging of visuospatial processing in Alzheimer's disease.

Abstract：

:Alzheimer's disease (AD) is known to cause a variety of disturbances of higher visual functions that are closely related to the neuropathological changes. Visual association areas are more affected than primary visual cortex. Additionally, there is evidence from neuropsychological and imaging studies during rest or passive visual stimulation that the occipitotemporal pathway is less affected than the parietal pathway. Our goal was to investigate functional activation patterns during active visuospatial processing in AD patients and the impact of local cerebral atrophy on the strength of functional activation. Fourteen AD patients and fourteen age-matched controls were measured with functional magnetic resonance imaging (fMRI) while they performed an angle discrimination task. Both groups revealed overlapping networks engaged in angle discrimination including the superior parietal lobule (SPL), frontal and occipitotemporal (OTC) cortical regions, primary visual cortex, basal ganglia, and thalamus. The most pronounced differences between the two groups were found in the SPL (more activity in controls) and OTC (more activity in patients). The differences in functional activation between the AD patients and controls were partly explained by the differences in individual SPL atrophy. These results indicate that parietal dysfunction in mild to moderate AD is compensated by recruitment of the ventral visual pathway. We furthermore suggest that local cerebral atrophy should be considered as a covariate in functional imaging studies of neurodegenerative disorders.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Prvulovic D,Hubl D,Sack AT,Melillo L,Maurer K,Frölich L,Lanfermann H,Zanella FE,Goebel R,Linden DE,Dierks T

doi

10.1006/nimg.2002.1271

keywords:

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

1403-14

issue

3

eissn

1053-8119

issn

1095-9572

pii

S1053811902912711

journal_volume

17

pub_type

杂志文章

相关文献

NEUROIMAGE文献大全
  • The influence of the diffusion of responsibility effect on outcome evaluations: electrophysiological evidence from an ERP study.

    abstract：:Previous studies have revealed that personal responsibility has an influence on outcome evaluation, although the way this influence works is still unclear. This study imitated the phenomenon of responsibility diffusion in a laboratory to examine the influence of the effect of responsibility diffusion on the processing...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.04.275

    authors： Li P,Jia S,Feng T,Liu Q,Suo T,Li H

    更新日期：2010-10-01 00:00:00

  • Optimal use of EEG recordings to target active brain areas with transcranial electrical stimulation.

    abstract：:To demonstrate causal relationships between brain and behavior, investigators would like to guide brain stimulation using measurements of neural activity. Particularly promising in this context are electroencephalography (EEG) and transcranial electrical stimulation (TES), as they are linked by a reciprocity principle...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.05.059

    authors： Dmochowski JP,Koessler L,Norcia AM,Bikson M,Parra LC

    更新日期：2017-08-15 00:00:00

  • Unsupervised multiparametric classification of dynamic susceptibility contrast imaging: study of the healthy brain.

    abstract：:Characterization and quantification of magnetic resonance perfusion images is important for clinical interpretation, though this calls for a reproducible and accurate method of analysis and a robust healthy reference. The few studies which have examined the perfusion of the healthy brain using dynamic susceptibility c...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.03.027

    authors： Artzi M,Aizenstein O,Hendler T,Ben Bashat D

    更新日期：2011-06-01 00:00:00

  • Simultaneous control of error rates in fMRI data analysis.

    abstract：:The key idea of statistical hypothesis testing is to fix, and thereby control, the Type I error (false positive) rate across samples of any size. Multiple comparisons inflate the global (family-wise) Type I error rate and the traditional solution to maintaining control of the error rate is to increase the local (compa...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.08.009

    authors： Kang H,Blume J,Ombao H,Badre D

    更新日期：2015-12-01 00:00:00

  • Double dissociation between action-driven and perception-driven conflict resolution invoking anterior versus posterior brain systems.

    abstract：:The ability to select and integrate relevant information in the presence of competing irrelevant information can be enhanced by advance information to direct attention and guide response selection. Attentional preparation can reduce perceptual and response conflict, yet little is known about the neural source of confl...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.06.058

    authors： Schulte T,Müller-Oehring EM,Vinco S,Hoeft F,Pfefferbaum A,Sullivan EV

    更新日期：2009-11-01 00:00:00

  • SIFT: Spherical-deconvolution informed filtering of tractograms.

    abstract：:Diffusion MRI allows the structural connectivity of the whole brain (the 'tractogram') to be estimated in vivo non-invasively using streamline tractography. The biological accuracy of these data sets is however limited by the inherent biases associated with the reconstruction method. Here we propose a method to retros...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2012.11.049

    authors： Smith RE,Tournier JD,Calamante F,Connelly A

    更新日期：2013-02-15 00:00:00

  • Establishing the reproducibility of two approaches to quantify white matter tract integrity in stroke.

    abstract：:Diffusion tensor imaging can provide unique and detailed information about white matter anatomy following stroke. Fiber tract reconstruction using tract-based techniques and cross-sectional region of interest delineation are two common approaches to quantify white matter integrity. After stroke, white matter tract int...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.09.009

    authors： Borich MR,Wadden KP,Boyd LA

    更新日期：2012-02-01 00:00:00

  • A semi-parametric approach to estimate the family-wise error rate in fMRI using resting-state data.

    abstract：:One of the most important considerations in any hypothesis based fMRI data analysis is to choose the appropriate threshold to construct the activation maps, which is usually based on p-values. However, in fMRI data, there are three factors which necessitate severe corrections in the process of estimating the p-values....

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.10.025

    authors： Nandy R,Cordes D

    更新日期：2007-02-15 00:00:00

  • Multifaceted genomic risk for brain function in schizophrenia.

    abstract：:Recently, deriving candidate endophenotypes from brain imaging data has become a valuable approach to study genetic influences on schizophrenia (SZ), whose pathophysiology remains unclear. In this work we utilized a multivariate approach, parallel independent component analysis, to identify genomic risk components ass...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2012.03.022

    authors： Chen J,Calhoun VD,Pearlson GD,Ehrlich S,Turner JA,Ho BC,Wassink TH,Michael AM,Liu J

    更新日期：2012-07-16 00:00:00

  • Interaction of hippocampal volume and N-acetylaspartate concentration deficits in schizophrenia: a combined MRI and 1H-MRS study.

    abstract：BACKGROUND:Volume deficits assessed with magnetic resonance imaging (MRI) and neurochemical dysfunctions (N-acetylaspartate, NAA) diagnosed using proton MR spectroscopy ((1)H-MRS) are reliable observations in the hippocampus of schizophrenic patients. NAA is an important cerebral amino acid in the synthesis pathways of...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.06.006

    authors： Klär AA,Ballmaier M,Leopold K,Häke I,Schaefer M,Brühl R,Schubert F,Gallinat J

    更新日期：2010-10-15 00:00:00

  • Cognitive emotion regulation enhances aversive prediction error activity while reducing emotional responses.

    abstract：:Cognitive emotion regulation is a powerful way of modulating emotional responses. However, despite the vital role of emotions in learning, it is unknown whether the effect of cognitive emotion regulation also extends to the modulation of learning. Computational models indicate prediction error activity, typically obse...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.08.038

    authors： Mulej Bratec S,Xie X,Schmid G,Doll A,Schilbach L,Zimmer C,Wohlschläger A,Riedl V,Sorg C

    更新日期：2015-12-01 00:00:00

  • Reproducibility of importance extraction methods in neural network based fMRI classification.

    abstract：:Recent advances in machine learning allow faster training, improved performance and increased interpretability of classification techniques. Consequently, their application in neuroscience is rapidly increasing. While classification approaches have proved useful in functional magnetic resonance imaging (fMRI) studies,...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.06.076

    authors： Gotsopoulos A,Saarimäki H,Glerean E,Jääskeläinen IP,Sams M,Nummenmaa L,Lampinen J

    更新日期：2018-11-01 00:00:00

  • Attention-dependent changes of activation and connectivity in dichotic listening.

    abstract：:Functional studies of auditory spatial attention generally report enhanced neural responses in auditory cortical regions. However, activity in regions of the spatial attentional network as described in the visual modality is not consistently observed. Data analysis limitations due to oppositely lateralized activity de...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章

    doi：

    authors： Lipschutz B,Kolinsky R,Damhaut P,Wikler D,Goldman S

    更新日期：2002-10-01 00:00:00

  • Mindboggle: a scatterbrained approach to automate brain labeling.

    abstract：:Mindboggle (http://www.binarybottle.com/mindboggle.html) is a fully automated, feature matching approach to label cortical structures and activity anatomically in human brain MRI data. This approach does not assume that the existence of component structures and their relative spatial relationship is preserved from bra...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2004.09.016

    authors： Klein A,Hirsch J

    更新日期：2005-01-15 00:00:00

  • Microglial Activation in the Right Amygdala-Entorhinal-Hippocampal Complex is Associated with Preserved Spatial Learning in AppNL-G-F mice.

    abstract：BACKGROUND:In Alzheimer`s disease (AD), regional heterogeneity of β-amyloid burden and microglial activation of individual patients is a well-known phenomenon. Recently, we described a high incidence of inter-individual regional heterogeneity in terms of asymmetry of plaque burden and microglial activation in β-amyloid...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2020.117707

    authors： Biechele G,Wind K,Blume T,Sacher C,Beyer L,Eckenweber F,Franzmeier N,Ewers M,Zott B,Lindner S,Gildehaus FJ,von Ungern-Sternberg B,Tahirovic S,Willem M,Bartenstein P,Cumming P,Rominger A,Herms J,Brendel M

    更新日期：2020-12-29 00:00:00

  • Structural brain variation and general intelligence.

    abstract：:Total brain volume accounts for about 16% of the variance in general intelligence scores (IQ), but how volumes of specific regions-of-interest (ROIs) relate to IQ is not known. We used voxel-based morphometry (VBM) in two independent samples to identify substantial gray matter (GM) correlates of IQ. Based on statistic...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2004.04.025

    authors： Haier RJ,Jung RE,Yeo RA,Head K,Alkire MT

    更新日期：2004-09-01 00:00:00

  • Processing of parafoveally presented words. An fMRI study.

    abstract：:The present fMRI study investigated neural correlates of parafoveal preprocessing during reading and the type of information that is accessible from the upcoming - not yet fixated - word. Participants performed a lexical decision flanker task while the constraints imposed by the first three letters (the initial trigra...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.08.061

    authors： Vignali L,Hawelka S,Hutzler F,Richlan F

    更新日期：2019-01-01 00:00:00

  • Quantitative examination of a novel clustering method using magnetic resonance diffusion tensor tractography.

    abstract：:MR diffusion tensor imaging (DTI) can measure and visualize organization of white matter fibre tracts in vivo. DTI is a relatively new imaging technique, and new tools developed for quantifying fibre tracts require evaluation. The purpose of this study was to compare the reliability of a novel clustering approach with...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2008.12.028

    authors： Voineskos AN,O'Donnell LJ,Lobaugh NJ,Markant D,Ameis SH,Niethammer M,Mulsant BH,Pollock BG,Kennedy JL,Westin CF,Shenton ME

    更新日期：2009-04-01 00:00:00

  • Distinct representations for facial identity and changeable aspects of faces in the human temporal lobe.

    abstract：:The neural system underlying face perception must represent the unchanging features of a face that specify identity, as well as the changeable aspects of a face that facilitate social communication. However, the way information about faces is represented in the brain remains controversial. In this study, we used fMR a...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.neuroimage.2004.07.060

    authors： Andrews TJ,Ewbank MP

    更新日期：2004-11-01 00:00:00

  • History of conditioned reward association disrupts inhibitory control: an examination of neural correlates.

    abstract：:The neural processes that support inhibitory control in the face of stimuli with a history of reward association are not yet well understood. Yet, the ability to flexibly adapt behavior to changing reward-contingency contexts is important for daily functioning and warrants further investigation. This study aimed to ch...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2020.117629

    authors： Meyer KN,Davidow JY,Van Dijk KRA,Santillana RM,Snyder J,Bustamante CMV,Hollinshead M,Rosen BR,Somerville LH,Sheridan MA

    更新日期：2020-12-13 00:00:00

  • Power estimation for non-standardized multisite studies.

    abstract：:A concern for researchers planning multisite studies is that scanner and T1-weighted sequence-related biases on regional volumes could overshadow true effects, especially for studies with a heterogeneous set of scanners and sequences. Current approaches attempt to harmonize data by standardizing hardware, pulse sequen...

    journal_title：NeuroImage

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.neuroimage.2016.03.051

    authors： Keshavan A,Paul F,Beyer MK,Zhu AH,Papinutto N,Shinohara RT,Stern W,Amann M,Bakshi R,Bischof A,Carriero A,Comabella M,Crane JC,D'Alfonso S,Demaerel P,Dubois B,Filippi M,Fleischer V,Fontaine B,Gaetano L,Goris A,Gr

    更新日期：2016-07-01 00:00:00

  • Nonlinear responses in fMRI: the Balloon model, Volterra kernels, and other hemodynamics.

    abstract：:There is a growing appreciation of the importance of nonlinearities in evoked responses in fMRI, particularly with the advent of event-related fMRI. These nonlinearities are commonly expressed as interactions among stimuli that can lead to the suppression and increased latency of responses to a stimulus that are incur...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1006/nimg.2000.0630

    authors： Friston KJ,Mechelli A,Turner R,Price CJ

    更新日期：2000-10-01 00:00:00

  • A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195.

    abstract：:[(11)C]-(R)-PK11195 is presently the most widely used radiotracer for the monitoring of microglia activity in the central nervous system (CNS). Microglia, the resident immune cells of the brain, play a critical role in acute and chronic diseases of the central nervous system and in host defence against neoplasia. The ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.02.017

    authors： Anderson AN,Pavese N,Edison P,Tai YF,Hammers A,Gerhard A,Brooks DJ,Turkheimer FE

    更新日期：2007-05-15 00:00:00

  • An evaluation of four automatic methods of segmenting the subcortical structures in the brain.

    abstract：:The automation of segmentation of subcortical structures in the brain is an active research area. We have comprehensively evaluated four novel methods of fully automated segmentation of subcortical structures using volumetric, spatial overlap and distance-based measures. Two methods are atlas-based - classifier fusion...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.05.029

    authors： Babalola KO,Patenaude B,Aljabar P,Schnabel J,Kennedy D,Crum W,Smith S,Cootes T,Jenkinson M,Rueckert D

    更新日期：2009-10-01 00:00:00

  • Evolution and resolution of human brain perfusion responses to the stress of induced hypoglycemia.

    abstract：:The relationship between the human brain response to acute stress and subjective, behavioural and physiological responses is poorly understood. We have examined the human cerebral response to the intense interoceptive stressor of hypoglycemia, controlling plasma glucose at either normal fasting concentrations (5 mmol/...

    journal_title：NeuroImage

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neuroimage.2010.06.033

    authors： Teh MM,Dunn JT,Choudhary P,Samarasinghe Y,Macdonald I,O'Doherty M,Marsden P,Reed LJ,Amiel SA

    更新日期：2010-11-01 00:00:00

  • Source localization of ictal epileptic activity investigated by high resolution EEG and validated by SEEG.

    abstract：:High resolution electroencephalography (HR-EEG) combined with source localization methods has mainly been used to study interictal spikes and there have been few studies comparing source localization of scalp ictal patterns with depth EEG. To address this issue, 10 patients with four different scalp ictal patterns (ic...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.02.067

    authors： Koessler L,Benar C,Maillard L,Badier JM,Vignal JP,Bartolomei F,Chauvel P,Gavaret M

    更新日期：2010-06-01 00:00:00

  • Robust automated constellation-based landmark detection in human brain imaging.

    abstract：:A robust fully automated algorithm for identifying an arbitrary number of landmark points in the human brain is described and validated. The proposed method combines statistical shape models with trained brain morphometric measures to estimate midbrain landmark positions reliably and accurately. Gross morphometric con...

    journal_title：NeuroImage

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroimage.2017.04.012

    authors： Ghayoor A,Vaidya JG,Johnson HJ

    更新日期：2018-04-15 00:00:00

  • Working memory for location and time: activity in prefrontal area 46 relates to selection rather than maintenance in memory.

    abstract：:The role of the dorsal prefrontal cortex in working memory remains controversial. Influential proposals include a role in the maintenance of domain-specific information, and the processes of executive functions on remembered information. We used event-related functional magnetic resonance imaging to demonstrate a func...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1006/nimg.2001.0784

    authors： Rowe JB,Passingham RE

    更新日期：2001-07-01 00:00:00

  • A direct test for lateralization of language activation using fMRI: comparison with invasive assessments in children with epilepsy.

    abstract：:This study introduces a direct method of assessing cerebral lateralization for language based on fMRI activation. The method, derived from a voxel-based morphometry study by C. H. Salmond et al. (2000, Hum. Brain Mapping 11, 223-232), bases lateralization on the direct statistical comparison of the magnitude of task-i...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1006/nimg.2002.1327

    authors： Liégeois F,Connelly A,Salmond CH,Gadian DG,Vargha-Khadem F,Baldeweg T

    更新日期：2002-12-01 00:00:00

  • A rapid topographic mapping and eye alignment method using optical imaging in Macaque visual cortex.

    abstract：:In optical imaging experiments, it is often advantageous to map the field of view and to converge the eyes without electrophysiological recording. This occurs when limited space precludes placement of an electrode or in chronic optical chambers in which one may not want to introduce an electrode each session or for de...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2008.10.007

    authors： Lu HD,Chen G,Ts'o DY,Roe AW

    更新日期：2009-02-01 00:00:00