Abstract:
:The question of the self has intrigued philosophers and psychologists for a long time. More recently, distinct concepts of self have also been suggested in neuroscience. However, the exact relationship between these concepts and neural processing across different brain regions remains unclear. This article reviews neuroimaging studies comparing neural correlates during processing of stimuli related to the self with those of non-self-referential stimuli. All studies revealed activation in the medial regions of our brains' cortex during self-related stimuli. The activation in these so-called cortical midline structures (CMS) occurred across all functional domains (e.g., verbal, spatial, emotional, and facial). Cluster and factor analyses indicate functional specialization into ventral, dorsal, and posterior CMS remaining independent of domains. Taken together, our results suggest that self-referential processing is mediated by cortical midline structures. Since the CMS are densely and reciprocally connected to subcortical midline regions, we advocate an integrated cortical-subcortical midline system underlying human self. We conclude that self-referential processing in CMS constitutes the core of our self and is critical for elaborating experiential feelings of self, uniting several distinct concepts evident in current neuroscience.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Northoff G,Heinzel A,de Greck M,Bermpohl F,Dobrowolny H,Panksepp Jdoi
10.1016/j.neuroimage.2005.12.002keywords:
subject
Has Abstractpub_date
2006-05-15 00:00:00pages
440-57issue
1eissn
1053-8119issn
1095-9572pii
S1053-8119(05)02515-2journal_volume
31pub_type
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