Abstract:
:Noise-normalization has been shown to partly compensate for the localization bias towards superficial sources in minimum norm estimation. However, it has been argued that in order to make inferences for the case of multiple sources, localization properties alone are insufficient. Instead, multiple measures of resolution should be applied to both point-spread and cross-talk functions (PSFs and CTFs). Here, we demonstrate that noise-normalization affects the shapes of PSFs, but not of CTFs. We evaluated PSFs and CTFs for the MNE, dSPM and sLORETA inverse operators, on the metrics dipole localization error (DLE), spatial dispersion (SD) and overall amplitude (OA). We used 306-channel MEG configurations obtained from 17 subjects in a real experiment, including individual noise covariance matrices and head geometries. We confirmed that for PSFs DLE improved after noise normalization, and is zero for sLORETA. However, SD was generally lower for the unnormalized MNE. OA distributions were similar for all three methods, indicating that all three methods may greatly underestimate some sources relative to others. The reliability of differences between methods across subjects was demonstrated using distributions of standard deviations and p-values from paired t-tests. As predicted, the shapes of CTFs were the same for all methods, reflecting the general resolution limits of the inverse problem. This means that noise-normalization is of no consequence where linear estimation procedures are used as "spatial filters." While low DLE is advantageous for the localization of a single source, or possibly a few spatially distinct sources, the benefit for the case of complex source distributions is not obvious. We suggest that software packages for source estimation should include comprehensive tools for evaluating the performance of different methods.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Hauk O,Wakeman DG,Henson Rdoi
10.1016/j.neuroimage.2010.09.053subject
Has Abstractpub_date
2011-02-01 00:00:00pages
1966-74issue
3eissn
1053-8119issn
1095-9572pii
S1053-8119(10)01253-Xjournal_volume
54pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract::Most neuroscience cognitive experiments involve repeated presentations of various stimuli across several minutes or a few hours. It has been observed that brain responses, even to the same stimulus, evolve over the course of the experiment. These changes in brain activation and connectivity are believed to be associat...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.11.061
更新日期:2018-10-15 00:00:00
abstract::Grey matter (GM) maturation has not been previously studied in healthy preterm children. The purpose of this study was to evaluate the age dependency of GM development in 116 GM areas in preterm subjects. Sixty one preterm infants (corrected age: 13.7+/-9.92 months, gestational age: 33.4+/-1.9 weeks) with normal struc...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.03.072
更新日期:2009-10-01 00:00:00
abstract::The medial prefrontal cortex (mPFC) is reliably activated by both performance and prediction errors. Error signals have typically been treated as a scalar, and it is unknown to what extent multiple error signals may co-exist within mPFC. Previous studies have shown that lateral frontal cortex (LFC) is arranged in a hi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.08.063
更新日期:2016-01-01 00:00:00
abstract::The primary gustatory area is located in the insular cortex. Although the insular cortex has been the topic of multiple parcellation studies, its functional specialization regarding taste processing received relatively little attention. Studies investigating the brain response to taste suggested that the insular corte...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.06.062
更新日期:2015-10-01 00:00:00
abstract::The female brain contains a larger proportion of gray matter tissue, while the male brain comprises more white matter. Findings like these have sparked increasing interest in studying dimorphism of the human brain: the general effect of gender on aspects of brain architecture. To date, the vast majority of imaging stu...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.12.068
更新日期:2013-04-15 00:00:00
abstract::Working memory is a fundamental cognitive building block involved in the short-term maintenance and transformation of information. In neuropsychological studies, working memory has been shown to be of limited capacity; however, the neurophysiological concomitants of this capacity limitation have not been explored. In ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.1998.0338
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:High sensation-seekers (HSS) pursue novelty even at the cost of self-harm. When challenged, HSS are less anxious, show blunted physiological (cortisol, startle) and neurobiological (prefrontal-limbic) responses, and devalue aversive outcomes. Here, we investigate how these features interact under conditions ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.08.038
更新日期:2014-12-01 00:00:00
abstract::Social exclusion and risk-taking are both common experiences of concern in adolescence, yet little is known about how the two may be related at behavioral or neural levels. In this fMRI study, adolescents (N=27, 14 male, 14-17years-old) completed a series of tasks in the scanner assessing risky decision-making before ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.05.061
更新日期:2013-11-15 00:00:00
abstract::This work describes a reproducibility analysis of scalar water diffusion parameters, measured within white matter tracts segmented using a probabilistic shape modelling method. In common with previously reported neighbourhood tractography (NT) work, the technique optimises seed point placement for fibre tracking by ma...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.12.010
更新日期:2009-04-01 00:00:00
abstract::It has been shown repeatedly that perceiving itch-related pictures or listening to a lecture on itch can enhance itch sensation and scratching behaviour (Niemeier and Gieler, 2000; Holle et al., 2012; Lloyd et al., 2013), indicating that itch is strongly influenced by expectations. Using fMRI, we investigated the neur...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.10.056
更新日期:2018-02-01 00:00:00
abstract::Facilitation of emotional face recognition is an established phenomenon for audiovisual crossmodal stimulation, but not for other sensory modalities. The present study used a crossmodal priming task to identify brain systems controlling olfactory-visual interactions during emotion processing. BOLD fMRI was acquired fo...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.07.012
更新日期:2010-11-01 00:00:00
abstract::Individuals born preterm with very low birth weight (VLBW; birth weight ≤ 1500 g) are at high risk for perinatal brain injuries and deviant brain development, leading to increased chances of later cognitive, emotional, and behavioral problems. Here we investigated the neuronal underpinnings of both reactive and proact...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.11.055
更新日期:2018-02-15 00:00:00
abstract::The focus of our magnetoencephalographic (MEG) study was to obtain further insight into the neuronal organization of language processing in stutterers. We recorded neuronal activity of 10 male developmental stutterers and 10 male controls, while they listened to pure tones, to words in order to repeat them, and to sen...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.11.024
更新日期:2005-04-15 00:00:00
abstract::Cerebral white matter lesions are associated with poorer motor performances in the elderly, but the role of gray matter atrophy remains largely unknown. We investigated the cross-sectional relation between brain regional gray matter volumes and walking speed over 6m in the 3C-Dijon study, a large population-based stud...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.01.102
更新日期:2012-04-02 00:00:00
abstract::Depression is the most frequent psychiatric disorder in Parkinson's disease (PD). Although evidence suggests that depression in PD is related to the degenerative process that underlies the disease, further studies are necessary to better understand the neural basis of depression in this population of patients. In orde...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.04.059
更新日期:2009-08-15 00:00:00
abstract::Caffeine is the most widely used stimulant in the world. The stimulant effects of caffeine are mediated through its antagonistic properties on neuronal adenosine receptors. In addition, caffeine blocks neurovascular adenosine receptors and decreases cerebral perfusion. Although the effects of caffeine on blood oxygena...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2002-10-01 00:00:00
abstract::Alterations in myelin integrity are involved in many neurological disorders and demyelinating diseases, such as multiple sclerosis (MS). Although magnetic resonance imaging (MRI) is the gold standard method to diagnose and monitor MS patients, clinically available MRI protocols show limited specificity for myelin dete...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116415
更新日期:2020-03-01 00:00:00
abstract::Whole brain extraction is an important pre-processing step in neuroimage analysis. Manual or semi-automated brain delineations are labour-intensive and thus not desirable in large studies, meaning that automated techniques are preferable. The accuracy and robustness of automated methods are crucial because human exper...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.12.067
更新日期:2011-04-01 00:00:00
abstract::In 2001, we published a paper on the representation of faces and objects in ventral temporal cortex that introduced a new method for fMRI analysis, which subsequently came to be called multivariate pattern analysis (MVPA). MVPA now refers to a diverse set of methods that analyze neural responses as patterns of activit...
journal_title:NeuroImage
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neuroimage.2012.03.016
更新日期:2012-08-15 00:00:00
abstract::Group level statistical maps of blood oxygenation level dependent (BOLD) signals acquired using functional magnetic resonance imaging (fMRI) have become a basic measurement for much of systems, cognitive and social neuroscience. A challenge in making inferences from these statistical maps is the noise and potential co...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.11.052
更新日期:2013-03-01 00:00:00
abstract::As the use of ultra-high field (UHF; ≥7T) magnetic resonance (MR) imaging expands, there is an increasing need to establish high-resolution MR imaging protocols for patients with neurological disease. Magnetization transfer (MT) imaging has been used to provide information about changes in the magnitude of the restric...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.09.009
更新日期:2018-03-01 00:00:00
abstract::Non-invasive imaging has the potential to play a crucial role in the characterization and translation of experimental animal models to investigate human brain development and disorders, especially when employed to study animal models that more accurately represent features of human neuroanatomy. The purpose of this st...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.03.009
更新日期:2017-05-15 00:00:00
abstract::The serotonin transporter (SERT) modulates the entire serotonergic system in the brain and influences both the dopaminergic and norepinephrinergic systems. These three systems are intimately involved in normal physiological functioning of the brain and implicated in numerous pathological conditions. Here we use high-r...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.03.026
更新日期:2009-07-15 00:00:00
abstract::Psychologists have been trying to understand differences in cognition and behavior between East Asian and Western cultures within a single cognitive framework such as holistic versus analytic or interdependent versus independent processes. However, it remains unclear whether cultural differences in multiple psychologi...
journal_title:NeuroImage
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.neuroimage.2014.05.062
更新日期:2014-10-01 00:00:00
abstract::Schippers, Renken and Keysers (NeuroImage, 2011) present a simulation of multi-subject lag-based causality estimation. We fully agree that single-subject evaluations (e.g., Smith et al., 2011) need to be revisited in the context of multi-subject studies, and Schippers' paper is a good example, including detailed multi...
journal_title:NeuroImage
pub_type: 评论,杂志文章
doi:10.1016/j.neuroimage.2011.08.015
更新日期:2012-01-16 00:00:00
abstract::An important aspect of the fear response is the allocation of spatial attention toward threatening stimuli. This response is so powerful that modulations in spatial attention can occur automatically without conscious awareness. Functional neuroimaging research suggests that the amygdala and anterior cingulate cortex (...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.09.040
更新日期:2012-01-16 00:00:00
abstract::Life stress has been shown to impact cognitive functions, including inhibitory control. However, the immediate effects of acute stress on inhibitory control and the underlying neural mechanisms remain unclear. In a behavioral pilot study (N = 30) and a within-subject functional magnetic resonance imaging study (N = 30...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116212
更新日期:2020-01-01 00:00:00
abstract::Spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) signal, as measured by functional magnetic resonance imaging (fMRI) at rest, exhibit a temporally coherent activity thought to reflect functionally relevant networks. Antero-mesial temporal structures are the site of early pathological changes in...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.05.090
更新日期:2011-09-15 00:00:00
abstract::There are now a number of non-invasive methods to image human brain function in-vivo. However, the accuracy of these images remains unknown and can currently only be estimated through the use of invasive recordings to generate a functional ground truth. Neuronal activity follows grey matter structure and accurate esti...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.02.033
更新日期:2014-07-01 00:00:00
abstract::To exploit the high (millisecond) temporal resolution of magnetoencephalography (MEG) and electroencephalography (EEG) for measuring neuronal dynamics within well-defined brain regions, it is important to quantitatively assess their localizing ability. Previous modeling studies and empirical data suggest that a combin...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.03.066
更新日期:2007-07-15 00:00:00