当前位置： SCI文献检索 > NEUROIMAGE期刊下所有文献 > Reward circuitry is perturbed in the absence of the serotonin transporter.

Reward circuitry is perturbed in the absence of the serotonin transporter.

Abstract：

:The serotonin transporter (SERT) modulates the entire serotonergic system in the brain and influences both the dopaminergic and norepinephrinergic systems. These three systems are intimately involved in normal physiological functioning of the brain and implicated in numerous pathological conditions. Here we use high-resolution magnetic resonance imaging (MRI) and spectroscopy to elucidate the effects of disruption of the serotonin transporter in an animal model system: the SERT knock-out mouse. Employing manganese-enhanced MRI, we injected Mn(2+) into the prefrontal cortex and obtained 3D MR images at specific time points in cohorts of SERT and normal mice. Statistical analysis of co-registered datasets demonstrated that active circuitry originating in the prefrontal cortex in the SERT knock-out is dramatically altered, with a bias towards more posterior areas (substantia nigra, ventral tegmental area, and Raphé nuclei) directly involved in the reward circuit. Injection site and tracing were confirmed with traditional track tracers by optical microscopy. In contrast, metabolite levels were essentially normal in the SERT knock-out by in vivo magnetic resonance spectroscopy and little or no anatomical differences between SERT knock-out and normal mice were detected by MRI. These findings point to modulation of the limbic cortical-ventral striatopallidal by disruption of SERT function. Thus, molecular disruptions of SERT that produce behavioral changes also alter the functional anatomy of the reward circuitry in which all the monoamine systems are involved.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Bearer EL,Zhang X,Janvelyan D,Boulat B,Jacobs RE

doi

10.1016/j.neuroimage.2009.03.026

subject

Has Abstract

pub_date

2009-07-15 00:00:00

pages

1091-104

issue

4

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(09)00271-7

journal_volume

46

pub_type

杂志文章

相关文献

NEUROIMAGE文献大全
  • Goal-independent mechanisms for free response generation: creative and pseudo-random performance share neural substrates.

    abstract：:To what extent free response generation in different tasks uses common and task-specific neurocognitive processes has remained unclear. Here, we investigated overlap and differences in neural activity during musical improvisation and pseudo-random response generation. Brain activity was measured using fMRI in a group ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.07.016

    authors： de Manzano Ö,Ullén F

    更新日期：2012-01-02 00:00:00

  • Optimal use of EEG recordings to target active brain areas with transcranial electrical stimulation.

    abstract：:To demonstrate causal relationships between brain and behavior, investigators would like to guide brain stimulation using measurements of neural activity. Particularly promising in this context are electroencephalography (EEG) and transcranial electrical stimulation (TES), as they are linked by a reciprocity principle...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.05.059

    authors： Dmochowski JP,Koessler L,Norcia AM,Bikson M,Parra LC

    更新日期：2017-08-15 00:00:00

  • What do differences between multi-voxel and univariate analysis mean? How subject-, voxel-, and trial-level variance impact fMRI analysis.

    abstract：:Multi-voxel pattern analysis (MVPA) has led to major changes in how fMRI data are analyzed and interpreted. Many studies now report both MVPA results and results from standard univariate voxel-wise analysis, often with the goal of drawing different conclusions from each. Because MVPA results can be sensitive to latent...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2014.04.037

    authors： Davis T,LaRocque KF,Mumford JA,Norman KA,Wagner AD,Poldrack RA

    更新日期：2014-08-15 00:00:00

  • Neuroanatomical substrates involved in true and false memories for face.

    abstract：:We often mistake an unknown person for a familiar person because of the similarities in facial features. This phenomenon, known as false memory, has been investigated mainly using words, pictures, and shapes. Previous neuroimaging studies on false memory have shown that both true and false memories trigger a similar a...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2012.04.044

    authors： Iidaka T,Harada T,Kawaguchi J,Sadato N

    更新日期：2012-08-01 00:00:00

  • Polarity-specific effects of motor transcranial direct current stimulation on fMRI resting state networks.

    abstract：:Transcranial direct current stimulation (tDCS) has been used to modify motor performance in healthy and patient populations. However, our understanding of the large-scale neuroplastic changes that support such behavioural effects is limited. Here, we used both seed-based and independent component analyses (ICA) approa...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2013.11.037

    authors： Amadi U,Ilie A,Johansen-Berg H,Stagg CJ

    更新日期：2014-03-01 00:00:00

  • Brain activation modulated by the comprehension of normal and pseudo-word sentences of different processing demands: a functional magnetic resonance imaging study.

    abstract：:Recent data from lesion and brain imaging studies have questioned the well-established assumption of a close functional-anatomic link between syntax and Broca's area and semantics and Wernicke's area. In the present study we used functional magnetic resonance imaging (fMRI) to investigate the neuroanatomical correlate...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1006/nimg.2001.1026

    authors： Röder B,Stock O,Neville H,Bien S,Rösler F

    更新日期：2002-04-01 00:00:00

  • Challenges in image-guided therapy system design.

    abstract：:System development for image-guided therapy (IGT), or image-guided interventions (IGI), continues to be an area of active interest across academic and industry groups. This is an emerging field that is growing rapidly: major academic institutions and medical device manufacturers have produced IGT technologies that are...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.04.026

    authors： Dimaio S,Kapur T,Cleary K,Aylward S,Kazanzides P,Vosburgh K,Ellis R,Duncan J,Farahani K,Lemke H,Peters T,Lorensen WB,Gobbi D,Haller J,Clarke LL,Pizer S,Taylor R,Galloway R Jr,Fichtinger G,Hata N,Lawson K,Tempany

    更新日期：2007-01-01 00:00:00

  • Bi-phase locking - a tool for probing non-linear interaction in the human brain.

    abstract：:We present a novel method for detecting frequency-frequency coupling between the electrical output of cortical areas as measured by electrocorticography (ECoG), electroencephalography (EEG) and magnetoencephalography (MEG), the biphase-locking value (bPLV). Our method is an extension of the well known phase-locking va...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.01.034

    authors： Darvas F,Ojemann JG,Sorensen LB

    更新日期：2009-05-15 00:00:00

  • The norepinephrine system and its relevance for multi-component behavior.

    abstract：:The ability to execute several actions in a specific temporal order to achieve an overarching goal, a process often termed action cascading or multi-component behavior, is essential for everyday life requirements. We are only at the beginning to understand the neurobiological mechanisms important for these cognitive p...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2016.10.007

    authors： Mückschel M,Gohil K,Ziemssen T,Beste C

    更新日期：2017-02-01 00:00:00

  • Achromatic synesthesias - a functional magnetic resonance imaging study.

    abstract：:Grapheme-color synesthetes experience consistent, automatic and idiosyncratic colors associated with specific letters and numbers. Frequently, these specific associations exhibit achromatic synesthetic qualities (e.g. white, black or gray). In this study, we have investigated for the first time the neural basis of ach...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2014.05.019

    authors： Melero H,Ríos-Lago M,Peña-Melián A,Álvarez-Linera J

    更新日期：2014-09-01 00:00:00

  • Elements of creative thought: Investigating the cognitive and neural correlates of association and bi-association processes.

    abstract：:Creative thinking relies on the ability to make remote associations and fruitfully combine unrelated concepts. Hence, original associations and bi-associations (i.e., associations to one and two concepts, respectively) are considered elementary cognitive processes of creative cognition. In this work, we investigated t...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2020.116586

    authors： Benedek M,Jurisch J,Koschutnig K,Fink A,Beaty RE

    更新日期：2020-04-15 00:00:00

  • Determinants of motion response anisotropies in human early visual cortex: the role of configuration and eccentricity.

    abstract：:Anisotropies in the cortical representation of various stimulus parameters can reveal the fundamental mechanisms by which sensory properties are analysed and coded by the brain. One example is the preference for motion radial to the point of fixation (i.e. centripetal or centrifugal) exhibited in mammalian visual cort...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2014.06.057

    authors： Maloney RT,Watson TL,Clifford CW

    更新日期：2014-10-15 00:00:00

  • Overlapping brain activity between episodic memory encoding and retrieval: roles of the task-positive and task-negative networks.

    abstract：:The notion that the brain is organized into two complementary networks, one that is task-positive and supports externally-oriented processing, and the other that is task-negative and supports internally-oriented processing, has recently attracted increasing attention. The goal of the present study was to investigate i...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.07.058

    authors： Kim H,Daselaar SM,Cabeza R

    更新日期：2010-01-01 00:00:00

  • Diffusion tensor microscopy in human nervous tissue with quantitative correlation based on direct histological comparison.

    abstract：:Thanks to its proven utility in both clinical and research applications, diffusion tensor tractography (DTT) is regularly employed as a means of delineating white-matter tracts. While successful efforts have been made to validate tractographic predictions, comparative methods which would permit the validation of such ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.04.052

    authors： Hansen B,Flint JJ,Heon-Lee C,Fey M,Vincent F,King MA,Vestergaard-Poulsen P,Blackband SJ

    更新日期：2011-08-15 00:00:00

  • Visualizing cortical activation during mental calculation with functional MRI.

    abstract：:Cortical activation during arithmetic calculation (silent subtraction by sevens) was compared to that observed during a control condition for which subjects were required to count forward by ones. Nine normal subjects underwent 1.5-T functional magnetic resonance imaging while performing these tasks. All subjects show...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1006/nimg.1996.0011

    authors： Rueckert L,Lange N,Partiot A,Appollonio I,Litvan I,Le Bihan D,Grafman J

    更新日期：1996-04-01 00:00:00

  • An examination of the effects of stimulus type, encoding task, and functional connectivity on the role of right prefrontal cortex in recognition memory.

    abstract：:Right anterior prefrontal cortex and other brain areas are active during memory retrieval but the role of prefrontal cortex and how it interacts with these other regions to mediate memory function remain unclear. To explore these issues we used positron emission tomography to examine the effects of stimulus material a...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1006/nimg.2001.0865

    authors： Grady CL,McIntosh AR,Beig S,Craik FI

    更新日期：2001-09-01 00:00:00

  • Optimized 3 T EPI of the amygdalae.

    abstract：:The optimum parameters for single-shot gradient-recalled (GR) EPI-based fMRI studies of the limbic region are systematically established at 3 T via their ability to mitigate intravoxel dephasing-measured via SNR and T2* in the amygdalae-and their implications for temporal resolution (or brain coverage). Conventional i...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.neuroimage.2003.12.048

    authors： Robinson S,Windischberger C,Rauscher A,Moser E

    更新日期：2004-05-01 00:00:00

  • Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis.

    abstract：:The primary goal of this study was to investigate associations between regional gray matter (GM) atrophy and neuropsychological function in multiple sclerosis (MS), while accounting for the influence of central brain atrophy (i.e. third ventricle enlargement). Using a cross-sectional design, we studied 59 MS patients ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.04.017

    authors： Tekok-Kilic A,Benedict RH,Weinstock-Guttman B,Dwyer MG,Carone D,Srinivasaraghavan B,Yella V,Abdelrahman N,Munschauer F,Bakshi R,Zivadinov R

    更新日期：2007-07-15 00:00:00

  • Dynamic event-related potentials and rapid source analysis reveals an intermittent short-lasting dysfrontality in schizophrenia.

    abstract：:Neuroimaging studies have identified regional brain dysfunctions in schizophrenia, but their dynamic consequences remain unclear. This study reports electrophysiological evaluation of medicated schizophrenic patients during performance of the Wisconsin Card Sorting Test. Using event-related potentials (ERPs), averaged...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/s1053-8119(03)00240-4

    authors： González-Hernández JA,Cedeño I,Pita-Alcorta C,Díaz-Comas L,Galán L,Figueredo-Rodriguez P

    更新日期：2003-08-01 00:00:00

  • Depression in Parkinson's disease: convergence from voxel-based morphometry and functional magnetic resonance imaging in the limbic thalamus.

    abstract：:Depression is the most frequent psychiatric disorder in Parkinson's disease (PD). Although evidence suggests that depression in PD is related to the degenerative process that underlies the disease, further studies are necessary to better understand the neural basis of depression in this population of patients. In orde...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.04.059

    authors： Cardoso EF,Maia FM,Fregni F,Myczkowski ML,Melo LM,Sato JR,Marcolin MA,Rigonatti SP,Cruz AC Jr,Barbosa ER,Amaro E Jr

    更新日期：2009-08-15 00:00:00

  • Normative database of the serotonergic system in healthy subjects using multi-tracer PET.

    abstract：:The highly diverse serotonergic system with at least 16 different receptor subtypes is implicated in the pathophysiology of most neuropsychiatric disorders including affective and anxiety disorders, obsessive compulsive disorder, post-traumatic stress disorder, eating disorders, sleep disturbance, attention deficit/hy...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2012.07.001

    authors： Savli M,Bauer A,Mitterhauser M,Ding YS,Hahn A,Kroll T,Neumeister A,Haeusler D,Ungersboeck J,Henry S,Isfahani SA,Rattay F,Wadsak W,Kasper S,Lanzenberger R

    更新日期：2012-10-15 00:00:00

  • Quantile rank maps: a new tool for understanding individual brain development.

    abstract：:We propose a novel method for neurodevelopmental brain mapping that displays how an individual's values for a quantity of interest compare with age-specific norms. By estimating smoothly age-varying distributions at a set of brain regions of interest, we derive age-dependent region-wise quantile ranks for a given indi...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2014.12.082

    authors： Chen H,Kelly C,Castellanos FX,He Y,Zuo XN,Reiss PT

    更新日期：2015-05-01 00:00:00

  • In vivo animation of auditory-language-induced gamma-oscillations in children with intractable focal epilepsy.

    abstract：:We determined if high-frequency gamma-oscillations (50- to 150-Hz) were induced by simple auditory communication over the language network areas in children with focal epilepsy. Four children (aged 7, 9, 10 and 16 years) with intractable left-hemispheric focal epilepsy underwent extraoperative electrocorticography (EC...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2008.03.011

    authors： Brown EC,Rothermel R,Nishida M,Juhász C,Muzik O,Hoechstetter K,Sood S,Chugani HT,Asano E

    更新日期：2008-07-01 00:00:00

  • Individual alpha peak frequency is related to latent factors of general cognitive abilities.

    abstract：:Some eighty years after the discovery of the human electroencephalogram (EEG) and its dominant rhythm, alpha (~10Hz), the neurophysiological functions and behavioral correlates of alpha oscillations are still under debate. Similarly, the biological mechanisms contributing to the general factor of intelligence, or g, h...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2013.04.059

    authors： Grandy TH,Werkle-Bergner M,Chicherio C,Lövdén M,Schmiedek F,Lindenberger U

    更新日期：2013-10-01 00:00:00

  • Theta rhythm supports hippocampus-dependent integrative encoding in schematic/semantic memory networks.

    abstract：:Integrating new information into existing schematic/semantic structures of knowledge is the basis of learning in our everyday life as it enables structured representation of information and goal-directed behaviour in an ever-changing environment. However, how schematic/semantic mnemonic structures aid the integration ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2020.117558

    authors： Nicolás B,Sala-Padró J,Cucurell D,Santurino M,Falip M,Fuentemilla L

    更新日期：2021-02-01 00:00:00

  • fMRI reflects functional connectivity of human somatosensory cortex.

    abstract：:Unilateral sensory stimulation reliably elicits contralateral somatotopic activation of primary (SI) and secondary (SII) somatosensory cortex. There is an ongoing debate about the occurrence and nature of concomitant ipsilateral SI and SII activation. Here we used functional magnetic resonance imaging (fMRI) in health...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.05.038

    authors： Blatow M,Nennig E,Durst A,Sartor K,Stippich C

    更新日期：2007-09-01 00:00:00

  • Development of BOLD signal hemodynamic responses in the human brain.

    abstract：:In the rodent brain the hemodynamic response to a brief external stimulus changes significantly during development. Analogous changes in human infants would complicate the determination and use of the hemodynamic response function (HRF) for functional magnetic resonance imaging (fMRI) in developing populations. We aim...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2012.06.054

    authors： Arichi T,Fagiolo G,Varela M,Melendez-Calderon A,Allievi A,Merchant N,Tusor N,Counsell SJ,Burdet E,Beckmann CF,Edwards AD

    更新日期：2012-11-01 00:00:00

  • Arm training induced brain plasticity in stroke studied with serial positron emission tomography.

    abstract：:We used serial positron emission tomography (PET) to study training-induced brain plasticity after severe hemiparetic stroke. Ten patients were randomized to either task-oriented arm training or to a control group and scanned before and after 22.6 +/- 1.6 days of treatment using passive movements as an activation para...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1006/nimg.2001.0757

    authors： Nelles G,Jentzen W,Jueptner M,Müller S,Diener HC

    更新日期：2001-06-01 00:00:00

  • Anxiolytic-like effect of pregabalin on unconditioned fear in the rat: an autoradiographic brain perfusion mapping and functional connectivity study.

    abstract：:Clinical and preclinical evidence suggests anxiolytic-like efficacy of pregabalin (PGB, Lyrica). However, its mechanism of action remains under investigation. The current study applied [(14)C]-iodoantipyrine cerebral blood flow (CBF) mapping to examine the effect of PGB on neural substrates underlying unconditioned fe...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.11.047

    authors： Wang Z,Pang RD,Hernandez M,Ocampo MA,Holschneider DP

    更新日期：2012-02-15 00:00:00

  • Episodic memory of APOE ε4 carriers is correlated with fractional anisotropy, but not cortical thickness, in the medial temporal lobe.

    abstract：:The ε4 allele of apolipoprotein E (apoE, protein; APOE, gene) is the most important genetic risk factor for the development of Alzheimer's disease (AD). Cortical structures in the medial temporal lobe (MTL) are important for memory function and are affected early in AD. Both gray matter (GM) and white matter (WM) stru...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2012.06.072

    authors： Westlye ET,Hodneland E,Haász J,Espeseth T,Lundervold A,Lundervold AJ

    更新日期：2012-10-15 00:00:00