Abstract:
:Integrating new information into existing schematic/semantic structures of knowledge is the basis of learning in our everyday life as it enables structured representation of information and goal-directed behaviour in an ever-changing environment. However, how schematic/semantic mnemonic structures aid the integration of novel elements remains poorly understood. Here, we showed that the ability to integrate novel picture information into learned structures of picture associations that overlapped by the same picture scene (i.e., simple network) or by a conceptually related picture scene (i.e., schematic/semantic network) is hippocampus-dependent, as patients with lesions at the medial temporal lobe (including the hippocampus) were impaired in inferring novel relations between pictures within these memory networks. We also found more persistent and widespread scalp EEG theta oscillations (3-5 Hz) while participants integrated novel pictures into schematic/semantic memory networks than into simple networks. On the other hand, greater neural similarity was observed between EEG patterns elicited by novel and related events within simple networks than between novel and related events within schematic/semantic memory networks. These findings have important implications for our understanding of the neural mechanisms that support the development and organization of structures of knowledge.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Nicolás B,Sala-Padró J,Cucurell D,Santurino M,Falip M,Fuentemilla Ldoi
10.1016/j.neuroimage.2020.117558subject
Has Abstractpub_date
2021-02-01 00:00:00pages
117558eissn
1053-8119issn
1095-9572pii
S1053-8119(20)31043-0journal_volume
226pub_type
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