Compensation of susceptibility-induced BOLD sensitivity losses in echo-planar fMRI imaging.

Abstract:

:Gradient-echo echo-planar imaging is a standard technique in functional magnetic resonance imaging (fMRI) experiments based on the blood oxygenation level-dependent (BOLD) effect. A major problem is the occurrence of susceptibility gradients near air/tissue interfaces. As a consequence, the detection of neuronal activation may be greatly compromised in certain brain areas, especially in the temporal lobes and in the orbitofrontal cortex. Common approaches to overcome this problem, such as z-shimming or the use of tailored radio frequency pulses, usually compensate only for susceptibility gradients in the slice selection direction. In the present study, the influence of susceptibility gradients in the phase encoding direction is investigated both theoretically and experimentally. It is shown that these gradients influence the effective echo time TE and may reduce considerably the local BOLD sensitivity, even in the case of acceptable image intensities. A compensation method is proposed and tested in an fMRI experiment based on a hypercapnic challenge. The results suggest that the compensation method allows for the detection of activation in brain areas which are usually unavailable for BOLD studies.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Deichmann R,Josephs O,Hutton C,Corfield DR,Turner R

doi

10.1006/nimg.2001.0985

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

120-35

issue

1

eissn

1053-8119

issn

1095-9572

pii

S1053811901909851

journal_volume

15

pub_type

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