Abstract:
:Aging is associated with gradual alterations in the neurochemical characteristics of the brain, which can be assessed in-vivo with proton-magnetic resonance spectroscopy (1H-MRS). However, the impact of these age-related neurochemical changes on functional motor behavior is still poorly understood. Here, we address this knowledge gap and specifically focus on the neurochemical integrity of the left sensorimotor cortex (SM1) and the occipital lobe (OCC), as both regions are main nodes of the visuomotor network underlying bimanual control. 1H-MRS data and performance on a set of bimanual tasks were collected from a lifespan (20-75 years) sample of 86 healthy adults. Results indicated that aging was accompanied by decreased levels of N-acetylaspartate (NAA), glutamate-glutamine (Glx), creatine + phosphocreatine (Cr) and myo-inositol (mI) in both regions, and decreased Choline (Cho) in the OCC region. Lower NAA and Glx levels in the SM1 and lower NAA levels in the OCC were related to poorer performance on a visuomotor bimanual coordination task, suggesting that NAA could serve as a potential biomarker for the integrity of the motor system supporting bimanual control. In addition, lower NAA, Glx, and mI levels in the SM1 were found to be correlates of poorer dexterous performance on a bimanual dexterity task. These findings highlight the role for 1H-MRS to study neurochemical correlates of motor performance across the adult lifespan.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Levin O,Weerasekera A,King BR,Heise KF,Sima DM,Chalavi S,Maes C,Peeters R,Sunaert S,Cuypers K,Van Huffel S,Mantini D,Himmelreich U,Swinnen SPdoi
10.1016/j.neuroimage.2019.116050subject
Has Abstractpub_date
2019-11-15 00:00:00pages
116050eissn
1053-8119issn
1095-9572pii
S1053-8119(19)30631-7journal_volume
202pub_type
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