Abstract:
:A key objective in neuroscience is to improve our understanding of the relationship between brain function and structure. We investigated this in the posterior visual pathways of healthy volunteers by applying functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) with tractography. The optic radiations were segmented using the Probabilistic Index of Connectivity (PICo) tractography algorithm and extracted at several thresholds of connection confidence. The mean fractional anisotropy (FA) of the estimated tracts was found to correlate significantly with fMRI measures of visual cortex activity (induced by a photic stimulation paradigm). The results support the hypothesis that the visual cortical fMRI response is constrained by the external anatomical connections of the subserving optic radiations.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Toosy AT,Ciccarelli O,Parker GJ,Wheeler-Kingshott CA,Miller DH,Thompson AJdoi
10.1016/j.neuroimage.2003.11.022keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
1452-63issue
4eissn
1053-8119issn
1095-9572pii
S1053811903007638journal_volume
21pub_type
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