Characterizing function-structure relationships in the human visual system with functional MRI and diffusion tensor imaging.

Abstract:

:A key objective in neuroscience is to improve our understanding of the relationship between brain function and structure. We investigated this in the posterior visual pathways of healthy volunteers by applying functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) with tractography. The optic radiations were segmented using the Probabilistic Index of Connectivity (PICo) tractography algorithm and extracted at several thresholds of connection confidence. The mean fractional anisotropy (FA) of the estimated tracts was found to correlate significantly with fMRI measures of visual cortex activity (induced by a photic stimulation paradigm). The results support the hypothesis that the visual cortical fMRI response is constrained by the external anatomical connections of the subserving optic radiations.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Toosy AT,Ciccarelli O,Parker GJ,Wheeler-Kingshott CA,Miller DH,Thompson AJ

doi

10.1016/j.neuroimage.2003.11.022

keywords:

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

1452-63

issue

4

eissn

1053-8119

issn

1095-9572

pii

S1053811903007638

journal_volume

21

pub_type

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