Connectivity-behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability.

Abstract:

:Correlations between temporal fluctuations in MRI signals may reveal functional connectivity between brain regions within individual subjects. Such correlations would be especially useful indices of functional connectivity if they covary with behavioral performance or other subject variables. This study investigated whether such a relationship could be demonstrated in the context of the reading circuit in the brain. The method proved sufficiently powerful to reveal significant correlations between the reading abilities of subjects and the strength of their functional connection between left Brodmann's area 39 and Broca's area during reading. This suggests that the disconnection of the angular gyrus previously reported for dyslexic readers is part of a larger continuum in which poor (but nonimpaired readers) also show reduced connectivity to the region. In addition, it illustrates the potential power of paradigms that examine correlations between behavior and functional brain connections.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Hampson M,Tokoglu F,Sun Z,Schafer RJ,Skudlarski P,Gore JC,Constable RT

doi

10.1016/j.neuroimage.2005.12.040

keywords:

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

513-9

issue

2

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(06)00012-7

journal_volume

31

pub_type

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