Abstract:
:The present study reported the development of a novel functional photoacoustic microscopy (fPAM) system for investigating hemodynamic changes in rat cortical vessels associated with electrical forepaw stimulation. Imaging of blood optical absorption by fPAM at multiple appropriately-selected and distinct wavelengths can be used to probe changes in total hemoglobin concentration (HbT, i.e., cerebral blood volume [CBV]) and hemoglobin oxygen saturation (SO(2)). Changes in CBV were measured by images acquired at a wavelength of 570nm (lambda(570)), an isosbestic point of the molar extinction spectra of oxy- and deoxy-hemoglobin, whereas SO(2) changes were sensed by pixel-wise normalization of images acquired at lambda(560) or lambda(600) to those at lambda(570). We demonstrated the capacity of the fPAM system to image and quantify significant contralateral changes in both SO(2) and CBV driven by electrical forepaw stimulation. The fPAM system complements existing imaging techniques, with the potential to serve as a favorable tool for explicitly studying brain hemodynamics in animal models.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Liao LD,Li ML,Lai HY,Shih YY,Lo YC,Tsang S,Chao PC,Lin CT,Jaw FS,Chen YYdoi
10.1016/j.neuroimage.2010.03.065subject
Has Abstractpub_date
2010-08-15 00:00:00pages
562-70issue
2eissn
1053-8119issn
1095-9572pii
S1053-8119(10)00352-6journal_volume
52pub_type
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