Abstract：
:Recently proposed dynamic magnetic resonance (MR) inverse imaging (InI) is a novel parallel imaging reconstruction technique capable of improving the temporal resolution of blood-oxygen level-dependent (BOLD) contrast functional MRI (fMRI) to the order of milliseconds at the cost of moderate spatial resolution. Volumetric InI reconstructs spatial information from projection data by solving ill-posed inverse problems using simultaneous acquisitions from a RF coil array. Previously a spatial filtering technique based on linearly constrained minimum variance (LCMV) beamformer was suggested to localize the hemodynamic changes of dynamic InI data with improved spatial resolution and sensitivity. Here we report an advancement of the spatial filtering method, which combines the eigenspace projection of the measured data and the L1-norm minimization of the spatial filters' output noise amplitude, to further improve the detection power of BOLD contrast fMRI data. Using numerical simulation and in vivo data, we demonstrate that this eigenspace linearly constrained minimum amplitude (eLCMA) beamformer can reconstruct spatiotemporal hemodynamic signals with high statistical significance values and high spatial resolution in event-related two-choice reaction time visuomotor experiments.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Liou ST,Witzel T,Nummenmaa A,Chang WT,Tsai KW,Kuo WJ,Chung HW,Lin FHdoi
10.1016/j.neuroimage.2010.11.072subject
Has Abstractpub_date
2011-03-01 00:00:00pages
87-100issue
1eissn
1053-8119issn
1095-9572pii
S1053-8119(10)01550-8journal_volume
55pub_type
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