Abstract：
:This study used arterial spin labeling (ASL) fMRI to measure brain perfusion in a group of healthy men under conditions that closely resembled customary sexual behavior. Serial perfusion measures for 30 min during two self-limited periods of partnered penis stimulation, and during post-stimulatory periods, revealed novel sexual activity-related cerebral blood flow (rCBF) changes, mainly in subcortical parts of the brain. Ventral pallidum rCBF was highest during the onset of penile erection, and lowest after the termination of penis stimulation. The perceived level of sexual arousal showed the strongest positive association with rCBF in the right basal forebrain. In addition, our results demonstrate that distinct subregions of the hypothalamus and cingulate cortex subserve opposite functions during human male sexual behavior. The lateral hypothalamus and anterior part of the middle cingulate cortex showed increased rCBF correlated with penile erection. By contrast, the anteroventral hypothalamus and subgenual anterior cingulate cortex exhibited rCBF changes correlated with penile detumescence after penile stimulation. Continuous rapid and high-resolution brain perfusion imaging during normal sexual activity has provided novel insights into the central mechanisms that control male sexual arousal.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Georgiadis JR,Farrell MJ,Boessen R,Denton DA,Gavrilescu M,Kortekaas R,Renken RJ,Hoogduin JM,Egan GFdoi
10.1016/j.neuroimage.2009.12.034subject
Has Abstractpub_date
2010-03-01 00:00:00pages
208-16issue
1eissn
1053-8119issn
1095-9572pii
S1053-8119(09)01323-8journal_volume
50pub_type
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