Abstract：
PURPOSE:To examine the extent of genetic damage, assessed from deoxyribonucleic acid (DNA) double-strand breaks (DSBs) and micronuclei (MN) in peripheral blood mononuclear cells obtained from individuals repeatedly exposed to 7T Magnetic Resonance Imaging (MRI). MATERIALS AND METHODS:The study protocol was approved by the local ethics committee. Informed consent was obtained from 22 healthy, non-smoking, non-alcoholic male individuals, who had never undergone radio-/chemo-therapy, scintigraphy, and had not undergone X-ray examination one year prior blood withdrawal. Eleven participants were repeatedly exposed to 7T and 3T MRI while working with/around scanners or frequently participating as 7T and lower field MRI research subjects (mean age 34±7years). The other half was never exposed to 7T or lower field MRI and served as controls (mean age 33±9years). The damage in lymphocytes was assessed using anti-γH2AX immunofluorescence staining of DNA DSBs and by quantification of MN. Isolated cells were further exposed in vitro to 7T MRI either alone or in the presence of the DNA damaging drug etoposide, to determine if there is any additional combined effect. The kinetics of DNA damage repair were examined. RESULTS:The mean base-level of γH2AX foci/cell and incidence of MN between repeatedly exposed and control group were not significantly different (P=0.618 and P=0.535, respectively). The additional in vitro exposure of cells to 7T MRI had no significant impact on MN frequencies and γH2AX foci at 1, 20 and 72h after exposure. CONCLUSION:Frequently repeated 7T MRI exposure did not result in a detectable increase in genotoxicity indices and alterations of DNA repair kinetics.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Fatahi M,Reddig A,Vijayalaxmi,Friebe B,Hartig R,Prihoda TJ,Ricke J,Roggenbuck D,Reinhold D,Speck Odoi
10.1016/j.neuroimage.2016.03.023subject
Has Abstractpub_date
2016-06-01 00:00:00pages
288-293eissn
1053-8119issn
1095-9572pii
S1053-8119(16)00228-7journal_volume
133pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract：:The chronology of the component processes subserving working memory (WM) and hemodynamic response lags has hindered the use of fMRI for exploring neural substrates of WM. In the present study, however, participants completed full trials that involved encoding two or six letters, maintaining the memory set over a delay...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.08.054
更新日期：2010-01-15 00:00:00
abstract：:Seventeen clinically stabilized monohemispheric stroke patients were studied in order to investigate the chronic topographical modifications induced on primary sensory cortical hand areas by a monohemispheric stroke within the middle cerebral artery territory. Magnetoencephalographic (MEG) localization of the cortical...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1006/nimg.2000.0686
更新日期：2001-08-01 00:00:00
abstract：:There is a pressing need for new therapeutic, diagnostic, and drug delivery approaches for treating brain cancers. Nanotechnology offers a new method for targeted brain cancer therapy and could play a major role in gene and drug delivery. The goals of our study were to visualize in vitro ingestion, cytotoxicity, and l...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2007.03.078
更新日期：2007-01-01 00:00:00
abstract：:Medical imaging has shown that, during early development, the brain undergoes more changes in size, shape and appearance than at any other time in life. A better understanding of brain development requires a spatio-temporal atlas that characterizes the dynamic changes during this period. In this paper we present an ap...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.09.062
更新日期：2012-02-01 00:00:00
abstract：:The brain's energy economy excessively favors intrinsic, spontaneous neural activity over extrinsic, evoked activity, presumably to maintain its internal organization. Emerging hypotheses capable of explaining such an investment posit that the brain's intrinsic functional architecture encodes a blueprint for its reper...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.10.046
更新日期：2011-02-14 00:00:00
abstract：:Thedomestic pig is increasingly being used as an experimental model for brain imaging studies with positron emission tomography (PET). The recording of radiotracer uptake by PET gives functional and physiological information, but with poor spatial resolution. To date, anatomical regions of interest in pig brain have b...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1006/nimg.2001.0910
更新日期：2001-11-01 00:00:00
abstract：:Intraoperative Thermal Imaging (ITI) is a novel neuroimaging technique that can potentially locate the margins of primary and metastatic brain tumors. As a result, the additional real-time anatomical and pathophysiological information may significantly contribute to an improved extent of tumor resection. Our objective...
journal_title：NeuroImage
pub_type： 杂志文章,评审
doi：10.1016/j.neuroimage.2009.03.043
更新日期：2009-08-01 00:00:00
abstract：:The thickness of the cerebral cortex can provide valuable information about normal and abnormal neuroanatomy. High resolution MRI together with powerful image processing techniques has made it possible to perform these measurements automatically over the whole brain. Here we present a method for automatically generati...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.01.027
更新日期：2008-05-01 00:00:00
abstract：:Multi-band echo planar imaging (MB-EPI), a new approach to increase data acquisition efficiency and/or temporal resolution, has the potential to overcome critical limitations of standard acquisition strategies for obtaining high-resolution whole brain perfusion imaging using arterial spin labeling (ASL). However, the ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.10.029
更新日期：2015-02-01 00:00:00
abstract：:The cascade model of cognitive control, mostly relying on functional neuroimaging studies, stipulates that the lateral frontal cortex (LFC) is organized as a cascade of executive processes involving three levels of cognitive control, implemented in distinct LFC areas from the premotor to the anterior prefrontal region...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2013.09.031
更新日期：2014-01-01 00:00:00
abstract：:Feedback error-related negativity (fERN) has been referred to as a negative deflection in the event related potential (ERP), which distinguishes between wins and losses in terms of expected and unexpected outcomes. Some studies refer to the "expected outcome" as the probability to win vs. to lose, and others as expect...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.03.031
更新日期：2010-07-01 00:00:00
abstract：:The human medial frontal cortex and especially the anterior cingulate cortex (ACC) have been implicated in several aspects of performance monitoring. We examined event-related EEG during a general process of controlling attention by using a novel paradigm to elicit a medial frontal negativity (MFN) to stimuli that ind...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.04.021
更新日期：2015-07-01 00:00:00
abstract：:Estimating moment-to-moment changes in blood oxygenation level dependent (BOLD) activation levels from functional magnetic resonance imaging (fMRI) data has applications for learned regulation of regional activation, brain state monitoring, and brain-machine interfaces. In each of these contexts, accurate estimation o...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.07.060
更新日期：2011-01-01 00:00:00
abstract：:White matter hyperintensities (WMH) are a frequent finding on brain MRI of elderly subjects, and have been associated with various risk factors, as well as with development of cognitive and functional impairment. While an overall association between WMH load and risk factors is well described, possible spatially restr...
journal_title：NeuroImage
pub_type： 杂志文章,多中心研究
doi：10.1016/j.neuroimage.2012.01.106
更新日期：2012-04-15 00:00:00
abstract：:Cognitive action control depends on cortical-subcortical circuits, involving notably the subthalamic nucleus (STN), as evidenced by local field potentials recordings (LFPs) studies. The STN consistently shows an increase in theta oscillations power during conflict resolution. Some studies have shown that cognitive act...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.04.071
更新日期：2019-08-15 00:00:00
abstract：:We present an experimental evaluation of a new algorithm for the detection of activated areas in brain functional maps. The new algorithm, named HMSD, is based on a hierarchical multiscale description of the difference image in terms of connected objects. Size and magnitude of each object are simultaneously tested wit...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1006/nimg.1995.1033
更新日期：1995-12-01 00:00:00
abstract：:We present methods for the quantitative analysis of brain growth based on the registration of longitudinal MR image data with the use of Jacobian determinant maps to characterise neuroanatomical changes. The individual anatomies, growth maps and tissue classes are also spatially normalised in an 'average space' and ag...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2007.07.067
更新日期：2008-01-01 00:00:00
abstract：:Recent studies of blood oxygenation level dependent (BOLD) signal responses averaged over a region of interest have demonstrated that the response is nonlinear with respect to stimulus duration. Specifically, shorter duration stimuli produce signal changes larger than expected from a linear system. The focus of this s...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1006/nimg.2001.0873
更新日期：2001-10-01 00:00:00
abstract：:Neural processing of dynamic continuous visual input, and cognitive influences thereon, are frequently studied in paradigms employing strictly rhythmic stimulation. However, the temporal structure of natural stimuli is hardly ever fully rhythmic but possesses certain spectral bandwidths (e.g. lip movements in speech, ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.11.043
更新日期：2017-02-01 00:00:00
abstract：:Sulcal pits, the locally deepest points in sulci of the highly convoluted and variable cerebral cortex, are found to be spatially consistent across human adult individuals. It is suggested that sulcal pits are genetically controlled and have close relationships with functional areas. To date, the existing imaging stud...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.06.004
更新日期：2014-10-15 00:00:00
abstract：:Linear parametric regression models of fMRI time series have correlated residuals. One approach to address this problem is to condition the autocorrelation structure by temporal smoothing. Smoothing splines with the degree of smoothing selected by generalized cross-validation (GCV-spline) provide a method to find an o...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/s1053-8119(03)00013-2
更新日期：2003-04-01 00:00:00
abstract：:We often mistake an unknown person for a familiar person because of the similarities in facial features. This phenomenon, known as false memory, has been investigated mainly using words, pictures, and shapes. Previous neuroimaging studies on false memory have shown that both true and false memories trigger a similar a...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.04.044
更新日期：2012-08-01 00:00:00
abstract：:Effects of age and sex, and their interaction on the structural brain anatomy of healthy elderly were assessed thanks to a cross-sectional study of a cohort of 662 subjects aged from 63 to 75 years. T1- and T2-weighted MRI scans were acquired in each subject and further processed using a voxel-based approach that was ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2005.02.042
更新日期：2005-07-01 00:00:00
abstract：:Animal experiments indicate that after repeated pairings of palatable food receipt and cues that predict palatable food receipt, dopamine signaling increases in response to predictive cues, but decreases in response to food receipt. Using functional MRI and mixed effects growth curve models with 35 females (M age=15.5...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.05.066
更新日期：2014-10-01 00:00:00
abstract：:The Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC - www.nitrc.org) suite of services include a resources registry, image repository and a cloud computational environment to meet the needs of the neuroimaging researcher. NITRC provides image-sharing functionality through both the NITRC Resource Regi...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.05.074
更新日期：2016-01-01 00:00:00
abstract：:Though the hippocampus has been associated with encoding and retrieval processes in episodic memory, the precise nature of its involvement in working memory has yet to be determined. This functional magnetic resonance imaging (fMRI) study employed a verbal working memory paradigm that allows for the within-subject com...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2005.01.038
更新日期：2005-05-01 00:00:00
abstract：:Quantitative research in neuroimaging often relies on anatomical segmentation of human brain MR images. Recent multi-atlas based approaches provide highly accurate structural segmentations of the brain by propagating manual delineations from multiple atlases in a database to a query subject and combining them. The atl...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.02.018
更新日期：2009-07-01 00:00:00
abstract：:We used functional magnetic resonance imaging (fMRI) to assess cortical activations associated with increasing task difficulty (TD) in a visuospatial paired associates learning task. Encoding and retrieval were examined when 100% successful retrieval of three, four, or six object-location pairs had been attained (thus...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/S1053-8119(03)00365-3
更新日期：2003-10-01 00:00:00
abstract：:Efficient encoding of relevant information and suppression of irrelevant information influence working memory (WM) performance, which is limited and declines in adulthood. A cued Sternberg WM task and electroencephalographic recordings (EEG) were used to investigate encoding and control operations in response to to-be...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.11.071
更新日期：2012-03-01 00:00:00
abstract：:Stereotypes associated with gender, race, ethnicity and religion are powerful forces in human social interactions. Previous neuroimaging and neuropsychological studies point to a role of the prefrontal cortex in controlling stereotypical responses. Here we used transcranial magnetic stimulation (TMS) in combination wi...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.02.037
更新日期：2011-06-01 00:00:00
