Abstract：
:The thickness of the cerebral cortex can provide valuable information about normal and abnormal neuroanatomy. High resolution MRI together with powerful image processing techniques has made it possible to perform these measurements automatically over the whole brain. Here we present a method for automatically generating voxel-based cortical thickness (VBCT) maps. This technique results in maps where each voxel in the grey matter is assigned a thickness value. Sub-voxel measurements of thickness are possible using sub-sampling and interpolation of the image information. The method is applied to repeated MRI scans of a single subject from two MRI scanners to demonstrate its robustness and reproducibility. A simulated data set is used to show that small focal differences in thickness between two groups of subjects can be detected. We propose that the analysis of VBCT maps can provide results that are complementary to other anatomical analyses such as voxel-based morphometry.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Hutton C,De Vita E,Ashburner J,Deichmann R,Turner Rdoi
10.1016/j.neuroimage.2008.01.027subject
Has Abstractpub_date
2008-05-01 00:00:00pages
1701-10issue
4eissn
1053-8119issn
1095-9572pii
S1053-8119(08)00080-3journal_volume
40pub_type
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