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The spatial distribution of age-related white matter changes as a function of vascular risk factors--results from the LADIS study.

Abstract：

:White matter hyperintensities (WMH) are a frequent finding on brain MRI of elderly subjects, and have been associated with various risk factors, as well as with development of cognitive and functional impairment. While an overall association between WMH load and risk factors is well described, possible spatially restricted vulnerability remains to be established. The aim of this study was to investigate the spatial distribution of WMH in normally functioning elderly subjects. We introduce a voxel-based approach in which lesion probability is mapped as a function of clinical risk factors using logistic regression, and validate the method using simulated datasets. The method was then applied in a total of 605 participants of the LADIS study (age 74 ± 5 years, all with WMH), and the location of manually delineated WMH was investigated after spatial normalisation. Particularly strong and widespread associations were found for age, gender and hypertension. Different distribution patterns were found for men and women. Further, increased probability was found in association with self-reported alcohol and tobacco consumption, as well as in those with a history of migraine. It is concluded that the location of WMH is dependent on the risk factors involved pointing towards a regionally different pathogenesis and/or vulnerability of the white matter.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Rostrup E,Gouw AA,Vrenken H,van Straaten EC,Ropele S,Pantoni L,Inzitari D,Barkhof F,Waldemar G,LADIS study group.

doi

10.1016/j.neuroimage.2012.01.106

subject

Has Abstract

pub_date

2012-04-15 00:00:00

pages

1597-607

issue

3

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(12)00124-3

journal_volume

60

pub_type

杂志文章,多中心研究

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