Abstract:
:Medical imaging has shown that, during early development, the brain undergoes more changes in size, shape and appearance than at any other time in life. A better understanding of brain development requires a spatio-temporal atlas that characterizes the dynamic changes during this period. In this paper we present an approach for constructing a 4D atlas of the developing brain, between 28 and 44 weeks post-menstrual age at time of scan, using T1 and T2 weighted MR images from 204 premature neonates. The method used for the creation of the average 4D atlas utilizes non-rigid registration between all pairs of images to eliminate bias in the atlas toward any of the original images. In addition, kernel regression is used to produce age-dependent anatomical templates. A novelty in our approach is the use of a time-varying kernel width, to overcome the variations in the distribution of subjects at different ages. This leads to an atlas that retains a consistent level of detail at every time-point. Comparisons between the resulting atlas and atlases constructed using affine and non-rigid registration are presented. The resulting 4D atlas has greater anatomic definition than currently available 4D atlases created using various affine and non-rigid registration approaches, an important factor in improving registrations between the atlas and individual subjects. Also, the resulting 4D atlas can serve as a good representative of the population of interest as it reflects both global and local changes. The atlas is publicly available at www.brain-development.org.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Serag A,Aljabar P,Ball G,Counsell SJ,Boardman JP,Rutherford MA,Edwards AD,Hajnal JV,Rueckert Ddoi
10.1016/j.neuroimage.2011.09.062subject
Has Abstractpub_date
2012-02-01 00:00:00pages
2255-65issue
3eissn
1053-8119issn
1095-9572pii
S1053-8119(11)01136-0journal_volume
59pub_type
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