Assessment of brain growth in early childhood using deformation-based morphometry.

Abstract:

:We present methods for the quantitative analysis of brain growth based on the registration of longitudinal MR image data with the use of Jacobian determinant maps to characterise neuroanatomical changes. The individual anatomies, growth maps and tissue classes are also spatially normalised in an 'average space' and aggregated to provide atlases for the population at each timepoint. The average space representation is obtained using the average intersubject transformation within each timepoint. In an exemplar study, this approach is used to assess brain development in 25 infants between 1 and 2 years, and we show consistency in growth estimates between registration and segmentation approaches.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Aljabar P,Bhatia KK,Murgasova M,Hajnal JV,Boardman JP,Srinivasan L,Rutherford MA,Dyet LE,Edwards AD,Rueckert D

doi

10.1016/j.neuroimage.2007.07.067

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

348-58

issue

1

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(07)00687-8

journal_volume

39

pub_type

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