Abstract：
:Patients with Bipolar Disorder (BD) perform poorly on tasks of selective attention and inhibitory control. Although similar behavioural deficits have been noted in their relatives, it is yet unclear whether they reflect dysfunction in the same neural circuits. We used functional magnetic resonance imaging and the Stroop Colour Word Task to compare task related neural activity between 39 euthymic BD patients, 39 of their first-degree relatives (25 with no Axis I disorders and 14 with Major Depressive Disorder) and 48 healthy controls. Compared to controls, all individuals with familial predisposition to BD, irrespective of diagnosis, showed similar reductions in neural responsiveness in regions involved in selective attention within the posterior and inferior parietal lobules. In contrast, hypoactivation within fronto-striatal regions, implicated in inhibitory control, was observed only in BD patients and MDD relatives. Although striatal deficits were comparable between BD patients and their MDD relatives, right ventrolateral prefrontal dysfunction was uniquely associated with BD. Our findings suggest that while reduced parietal engagement relates to genetic risk, fronto-striatal dysfunction reflects processes underpinning disease expression for mood disorders.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Pompei F,Jogia J,Tatarelli R,Girardi P,Rubia K,Kumari V,Frangou Sdoi
10.1016/j.neuroimage.2011.02.052subject
Has Abstractpub_date
2011-06-01 00:00:00pages
1677-84issue
3eissn
1053-8119issn
1095-9572pii
S1053-8119(11)00208-4journal_volume
56pub_type
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