Abstract:
:The neuropeptide oxytocin is a key modulator of social-emotional behavior and its intranasal administration can influence the functional connectivity of brain networks involved in the control of attention, emotion and reward reported in humans. However, no studies have systematically investigated the effects of oxytocin on dynamic or directional aspects of functional connectivity. The present study employed a novel computational framework to investigate these latter aspects in 15 oxytocin-sensitive regions using data from randomized placebo-controlled between-subject resting state functional MRI studies incorporating 200 healthy subjects. In order to characterize the temporal dynamics, the 'temporal state' was defined as a temporal segment of the whole functional MRI signal which exhibited a similar functional interaction pattern among brain regions of interest. Results showed that while no significant effects of oxytocin were found on brain temporal state related characteristics (including temporal state switching frequency, probability of transitions between neighboring states, and averaged dwell time on each state) oxytocin extensively (n = 54 links) modulated effective connectivity among the 15 regions. The effects of oxytocin were primarily characterized by increased effective connectivity both between and within emotion, reward, salience, attention and social cognition processing networks and their interactions with the default mode network. Top-down control over emotional processing regions such as the amygdala was particularly affected. Oxytocin also increased effective homotopic interhemispheric connectivity in almost all these regions. Additionally, the effects of oxytocin on effective connectivity were sex-dependent, being more extensive in males. Overall, these findings suggest that modulatory effects of oxytocin on both within- and between-network interactions may underlie its functional influence on social-emotional behaviors, although in a sex-dependent manner. These findings may be of particular relevance to potential therapeutic use of oxytocin in psychiatric disorders associated with social dysfunction, such as autism spectrum disorder and schizophrenia, where directionality of treatment effects on causal interactions between networks may be of key importance .
journal_name
Neuroimagejournal_title
NeuroImageauthors
Jiang X,Ma X,Geng Y,Zhao Z,Zhou F,Zhao W,Yao S,Yang S,Zhao Z,Becker B,Kendrick KMdoi
10.1016/j.neuroimage.2020.117668subject
Has Abstractpub_date
2020-12-24 00:00:00pages
117668eissn
1053-8119issn
1095-9572pii
S1053-8119(20)31153-8journal_volume
227pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract::Electroencephalography (EEG) recordings performed in magnetic resonance imaging (MRI) scanners are affected by complex artifacts caused by heart function, often termed pulse artifacts (PAs). PAs can strongly compromise EEG data quality, and remain an open problem for EEG-fMRI. This study investigated the properties an...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.02.021
更新日期:2019-05-01 00:00:00
abstract::There is mounting evidence that mindfulness meditation is beneficial for the treatment of mood and anxiety disorders, yet little is known regarding the neural mechanisms through which mindfulness modulates emotional responses. Thus, a central objective of this functional magnetic resonance imaging study was to investi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.06.001
更新日期:2011-08-15 00:00:00
abstract:BACKGROUND:The measurement of brain perfusion may provide valuable information for assessment and treatment of newborns with hypoxic-ischemic encephalopathy (HIE). While arterial spin labeled perfusion (ASL) magnetic resonance imaging (MRI) provides noninvasive and direct measurements of regional cerebral blood flow (C...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.04.072
更新日期:2014-01-15 00:00:00
abstract::MR diffusion tensor imaging (DTI) can measure and visualize organization of white matter fibre tracts in vivo. DTI is a relatively new imaging technique, and new tools developed for quantifying fibre tracts require evaluation. The purpose of this study was to compare the reliability of a novel clustering approach with...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.12.028
更新日期:2009-04-01 00:00:00
abstract::The human brain can be modeled as multiple interrelated shapes (or a multishape), each for characterizing one aspect of the brain, such as the cortex and white matter pathways. Predicting the developing multishape is a very challenging task due to the contrasting nature of the developmental trajectories of the constit...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.03.012
更新日期:2017-05-15 00:00:00
abstract::Whereas we know a fair amount on the role of the amygdala in the acute stress response, virtually nothing is known about its role during the recovery period after the stress has waned. Functional connectivity analysis of the amygdala during this period might be useful in revealing brain circuits promoting adaptive rec...
journal_title:NeuroImage
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neuroimage.2011.05.074
更新日期:2011-08-15 00:00:00
abstract::The present fMRI study investigated the hypothesis that activation of the left ventral occipitotemporal cortex (vOT) in response to auditory words can be attributed to lexical orthographic rather than lexico-semantic processing. To this end, we presented auditory words in both an orthographic ("three or four letter wo...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.09.039
更新日期:2016-01-01 00:00:00
abstract::Head motion causes artifacts in functional magnetic resonance imaging (fMRI) scans, a problem especially relevant for task-free resting state paradigms and for developmental, aging, and clinical populations. In a cohort spanning 7-28 years old (mean age 15) we produced customized head-anatomy-specific Styrofoam molds ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.01.016
更新日期:2019-04-01 00:00:00
abstract::Single-shot echo planar imaging (EPI) with parallel imaging techniques has been well established as the most popular method for clinical diffusion imaging, due to its fast acquisition and motion insensitivity. However, this approach is limited by the relatively low spatial resolution and image distortion. Interleaved ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.10.022
更新日期:2015-01-15 00:00:00
abstract::Naturally acquiring a language shapes the human brain through a long-lasting learning and practice process. This is supported by previous studies showing that managing more than one language from early childhood has an impact on brain structure and function. However, to what extent bilingual individuals present neuroa...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.09.073
更新日期:2016-01-15 00:00:00
abstract::This study aimed to determine regional pattern of tissue perfusion in the normal-appearing white matter (NAWM) of patients with primary-progressive (PP), relapsing-remitting (RR) multiple sclerosis (MS) and healthy controls, and to investigate the association between perfusion abnormalities and clinical disability. Us...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.08.008
更新日期:2006-12-01 00:00:00
abstract::This work addresses the choice of the imaging voxel volume in blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). Noise of physiological origin that is present in the voxel time course is a prohibitive factor in the detection of small activation-induced BOLD signal changes. If the physiol...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.09.039
更新日期:2007-01-15 00:00:00
abstract::Social connectedness theory posits that the brain processes social rejection as a threat to survival. Recent electrophysiological evidence suggests that midfrontal theta (4-8Hz) oscillations in the EEG provide a window on the processing of social rejection. Here we examined midfrontal theta dynamics (power and inter-t...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.08.045
更新日期:2017-02-01 00:00:00
abstract:UNLABELLED:The brainstem contains various important monoaminergic neuronal centers, including the raphe nuclei which contain serotonergic neurons. The raphe nuclei, however, are not easily identifiable and located by conventional neuroimaging. METHODS:Fluorodeoxyglucose positron emission tomography (PET) and magnetic ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.09.036
更新日期:2012-01-16 00:00:00
abstract::Recently, neuronal correlates of acupuncture stimulation in human brain have been investigated by functional neuroimaging. The preliminary findings suggest that acupuncture at analgesic points involves the pain-related neuromatrix and may have acupoint-brain correlation. Although multiple models of control stimulation...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2002.1145
更新日期:2002-08-01 00:00:00
abstract::Quantitative measurement of brain size, shape, and temporal change (for example, in order to estimate atrophy) is increasingly important in biomedical image analysis applications. New methods of structural analysis attempt to improve robustness, accuracy, and extent of automation. A fully automated method of longitudi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2002.1040
更新日期:2002-09-01 00:00:00
abstract::Picture-plane inversion dramatically impairs face recognition. Behavioral and event-related potential (ERP) studies suggest that this effect takes place during perceptual encoding of the face stimulus. However, the relationship between early electrophysiological responses to upright and inverted faces and the behavior...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.04.016
更新日期:2007-07-01 00:00:00
abstract::Self-related information, such as one's own face, is prioritized by our cognitive system. Whilst recent theoretical developments suggest that this is achieved by an interplay between bottom-up and top-down attentional mechanisms, their underlying neural dynamics are still poorly understood. Furthermore, it is still ma...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.116754
更新日期:2020-06-01 00:00:00
abstract::A concern for researchers planning multisite studies is that scanner and T1-weighted sequence-related biases on regional volumes could overshadow true effects, especially for studies with a heterogeneous set of scanners and sequences. Current approaches attempt to harmonize data by standardizing hardware, pulse sequen...
journal_title:NeuroImage
pub_type: 杂志文章,多中心研究
doi:10.1016/j.neuroimage.2016.03.051
更新日期:2016-07-01 00:00:00
abstract::Understanding the differences between individuals' personality types at a functional brain level is now possible due to recent developments in both functional brain imaging and personality models. The psychobiological model for temperament and character offers one approach to exploring personality. This study uses SPE...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/s1053-8119(03)00171-x
更新日期:2003-07-01 00:00:00
abstract::Automated measures of cerebral magnetic resonance images (MRI) often provide greater speed and reliability compared to manual techniques but can be particularly sensitive to motion artifact. This study employed an automatic MRI analysis program that quantified regional gray matter volume and created images for verific...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1006/nimg.2002.1076
更新日期:2002-05-01 00:00:00
abstract::Openness is a personality trait reflecting absorption in sensory experience, preference for novelty, and creativity, and is thus considered a driving force of human evolution. At the brain level, a relation between openness and dopaminergic circuits has been proposed, although evidence to support this hypothesis is la...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.09.017
更新日期:2015-01-01 00:00:00
abstract::Recent data from lesion and brain imaging studies have questioned the well-established assumption of a close functional-anatomic link between syntax and Broca's area and semantics and Wernicke's area. In the present study we used functional magnetic resonance imaging (fMRI) to investigate the neuroanatomical correlate...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2001.1026
更新日期:2002-04-01 00:00:00
abstract::Extracellular β-amyloid (Aβ) plaque deposits and inflammatory immune activation are thought to alter various aspects of tissue microstructure, such as extracellular free water, fractional anisotropy and diffusivity, as well as the density and geometric arrangement of axonal processes. Quantifying these microstructural...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116138
更新日期:2019-11-15 00:00:00
abstract::A well-recognized problem with the echo-planar imaging (EPI) technique most commonly used for functional magnetic resonance imaging (fMRI) studies is geometric distortion caused by magnetic field inhomogeneity. This makes it difficult to achieve an accurate registration between a functional activation map calculated f...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2001.1054
更新日期:2002-05-01 00:00:00
abstract::The publisher regrets due to an error in the publishing process the above articles was accidentally withdrawn and has now been published in (Neuroimage 83C December 2013 https://doi.org/10.1016/j.neuroimage.2013.05.115). The publisher would like to apologize for any inconvenience caused. ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.02.041
更新日期:2013-07-15 00:00:00
abstract::Cerebral artery segmentation plays an important role in the direct visualization of the human brain to obtain vascular system information. On ultra-high field magnetic resonance imaging, cerebral arteries appearing hyperintense on T1 weighted (T1w) images could be segmented from brain tissues such as gray and white ma...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117259
更新日期:2020-11-15 00:00:00
abstract::Functional neuroimaging studies demonstrate age-related differences in recruitment of a large-scale attentional network during interference resolution, especially within dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC). These alterations in functional responses have been frequently observed d...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.08.002
更新日期:2014-02-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) in animal models provides a platform for more extensive investigation of drug effects and underlying physiological mechanisms than is possible in humans. However, it is usually necessary for the animal to be anesthetized. In this study, we have used a rat model of direct co...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.08.011
更新日期:2005-01-01 00:00:00
abstract::The motor manifestations of Parkinson's disease (PD) have been linked to an abnormal spatial covariance pattern involving basal ganglia thalamocortical pathways. By contrast, little is known about the functional networks that underlie cognitive dysfunction in this disorder. To identify such patterns, we studied 15 non...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.09.003
更新日期:2007-01-15 00:00:00