Bilingualism at the core of the brain. Structural differences between bilinguals and monolinguals revealed by subcortical shape analysis.


:Naturally acquiring a language shapes the human brain through a long-lasting learning and practice process. This is supported by previous studies showing that managing more than one language from early childhood has an impact on brain structure and function. However, to what extent bilingual individuals present neuroanatomical peculiarities at the subcortical level with respect to monolinguals is yet not well understood, despite the key role of subcortical gray matter for a number of language functions, including monitoring of speech production and language control - two processes especially solicited by bilinguals. Here we addressed this issue by performing a subcortical surface-based analysis in a sample of monolinguals and simultaneous bilinguals (N=88) that only differed in their language experience from birth. This analysis allowed us to study with great anatomical precision the potential differences in morphology of key subcortical structures, namely, the caudate, accumbens, putamen, globus pallidus and thalamus. Vertexwise analyses revealed significantly expanded subcortical structures for bilinguals compared to monolinguals, localized in bilateral putamen and thalamus, as well as in the left globus pallidus and right caudate nucleus. A topographical interpretation of our results suggests that a more complex phonological system in bilinguals may lead to a greater development of a subcortical brain network involved in monitoring articulatory processes.






Burgaleta M,Sanjuán A,Ventura-Campos N,Sebastian-Galles N,Ávila C




Has Abstract


2016-01-15 00:00:00












  • Fast, fully automated global and local magnetic field optimization for fMRI of the human brain.

    abstract::The aim of this novel technique is to allow researchers, particularly those operating at high static magnetic field strengths on fMRI applications, to tailor the static magnetic field within the brain. The optimum solution for their experimental needs is reached, utilizing the full potential of the active shims at the...


    pub_type: 临床试验,杂志文章


    authors: Wilson JL,Jenkinson M,de Araujo I,Kringelbach ML,Rolls ET,Jezzard P

    更新日期:2002-10-01 00:00:00

  • The relationship between motor deficit and hemisphere activation balance after stroke: A 3T fMRI study.

    abstract::Functional imaging during movement of the hand affected by a stroke has shown excess activation of the contralesional motor network, implying less physiological hemisphere activation balance. Although this may be adaptive, the relationship between the severity of motor deficit and the hemisphere activation balance for...


    pub_type: 杂志文章


    authors: Calautti C,Naccarato M,Jones PS,Sharma N,Day DD,Carpenter AT,Bullmore ET,Warburton EA,Baron JC

    更新日期:2007-01-01 00:00:00

  • Automatic prediction error responses to hands with unexpected laterality: an electrophysiological study.

    abstract::Little is known about how the human brain keeps track of body parts in the visual field. Here we show that unattended images of right/left hands elicit a mismatch response when they violate a regularity established by repeated visual presentations of the other hand. In a visual oddball experiment we found mismatch res...


    pub_type: 杂志文章


    authors: Stefanics G,Czigler I

    更新日期:2012-10-15 00:00:00

  • Multisensory interactions in early evoked brain activity follow the principle of inverse effectiveness.

    abstract::A major determinant of multisensory integration, derived from single-neuron studies in animals, is the principle of inverse effectiveness (IE), which describes the phenomenon whereby maximal multisensory response enhancements occur when the constituent unisensory stimuli are minimally effective in evoking responses. H...


    pub_type: 杂志文章


    authors: Senkowski D,Saint-Amour D,Höfle M,Foxe JJ

    更新日期:2011-06-15 00:00:00

  • Improved determination of the myelin water fraction in human brain using magnetic resonance imaging through Bayesian analysis of mcDESPOT.

    abstract::Myelin water fraction (MWF) mapping with magnetic resonance imaging has led to the ability to directly observe myelination and demyelination in both the developing brain and in disease. Multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) has been proposed as a rapid approach for multicom...


    pub_type: 杂志文章


    authors: Bouhrara M,Spencer RG

    更新日期:2016-02-15 00:00:00

  • Local MEG networks: the missing link between protein expression and epilepsy in glioma patients?

    abstract::Connectivity and network analysis in neuroscience has been applied to multiple spatial scales, but the links between these different scales have rarely been investigated. In tumor-related epilepsy, altered network topology is related to behavior, but the molecular basis of these observations is unknown. We elucidate t...


    pub_type: 杂志文章


    authors: Douw L,de Groot M,van Dellen E,Aronica E,Heimans JJ,Klein M,Stam CJ,Reijneveld JC,Hillebrand A

    更新日期:2013-07-15 00:00:00

  • Tailored haemodynamic response function increases detection power of fMRI in awake dogs (Canis familiaris).

    abstract::Functional magnetic resonance imaging (fMRI) of awake and unrestrained dogs (Canis familiaris) has been established as a novel opportunity for comparative neuroimaging, promising important insights into the evolutionary roots of human brain function and cognition. However, data processing and analysis pipelines are of...


    pub_type: 杂志文章


    authors: Boch M,Karl S,Sladky R,Huber L,Lamm C,Wagner IC

    更新日期:2021-01-01 00:00:00

  • Anxiolytic-like effect of pregabalin on unconditioned fear in the rat: an autoradiographic brain perfusion mapping and functional connectivity study.

    abstract::Clinical and preclinical evidence suggests anxiolytic-like efficacy of pregabalin (PGB, Lyrica). However, its mechanism of action remains under investigation. The current study applied [(14)C]-iodoantipyrine cerebral blood flow (CBF) mapping to examine the effect of PGB on neural substrates underlying unconditioned fe...


    pub_type: 杂志文章


    authors: Wang Z,Pang RD,Hernandez M,Ocampo MA,Holschneider DP

    更新日期:2012-02-15 00:00:00

  • Dynamic intra- and interhemispheric interactions during unilateral and bilateral hand movements assessed with fMRI and DCM.

    abstract::Any motor action results from a dynamic interplay of various brain regions involved in different aspects of movement preparation and execution. Establishing a reliable model of how these areas interact is crucial for a better understanding of the mechanisms underlying motor function in both healthy subjects and patien...


    pub_type: 杂志文章


    authors: Grefkes C,Eickhoff SB,Nowak DA,Dafotakis M,Fink GR

    更新日期:2008-07-15 00:00:00

  • Testing the model of caudo-rostral organization of cognitive control in the human with frontal lesions.

    abstract::The cascade model of cognitive control, mostly relying on functional neuroimaging studies, stipulates that the lateral frontal cortex (LFC) is organized as a cascade of executive processes involving three levels of cognitive control, implemented in distinct LFC areas from the premotor to the anterior prefrontal region...


    pub_type: 杂志文章


    authors: Azuar C,Reyes P,Slachevsky A,Volle E,Kinkingnehun S,Kouneiher F,Bravo E,Dubois B,Koechlin E,Levy R

    更新日期:2014-01-01 00:00:00

  • Developmental stages and sex differences of white matter and behavioral development through adolescence: a longitudinal diffusion tensor imaging (DTI) study.

    abstract::White matter (WM) continues to mature through adolescence in parallel with gains in cognitive ability. To date, developmental changes in human WM microstructure have been inferred using analyses of cross-sectional or two time-point follow-up studies, limiting our understanding of individual developmental trajectories....


    pub_type: 杂志文章


    authors: Simmonds DJ,Hallquist MN,Asato M,Luna B

    更新日期:2014-05-15 00:00:00

  • Neural correlates of reflection on actual versus ideal self-discrepancy.

    abstract::Subjective feelings of actual/ideal self-discrepancy vary across individuals and influence one's own affective states. However, the neural correlates of actual/ideal self-discrepancy and their genetic individual differences remain unknown. We investigated neural correlates of actual/ideal self-discrepancy and their as...


    pub_type: 杂志文章


    authors: Shi Z,Ma Y,Wu B,Wu X,Wang Y,Han S

    更新日期:2016-01-01 00:00:00

  • The MNI data-sharing and processing ecosystem.

    abstract::Neuroimaging has been facing a data deluge characterized by the exponential growth of both raw and processed data. As a result, mining the massive quantities of digital data collected in these studies offers unprecedented opportunities and has become paramount for today's research. As the neuroimaging community enters...


    pub_type: 杂志文章


    authors: Das S,Glatard T,MacIntyre LC,Madjar C,Rogers C,Rousseau ME,Rioux P,MacFarlane D,Mohades Z,Gnanasekaran R,Makowski C,Kostopoulos P,Adalat R,Khalili-Mahani N,Niso G,Moreau JT,Evans AC

    更新日期:2016-01-01 00:00:00

  • Children's intellectual ability is associated with structural network integrity.

    abstract::Recent structural and functional neuroimaging studies of adults suggest that efficient patterns of brain connectivity are fundamental to human intelligence. Specifically, whole brain networks with an efficient small-world organization, along with specific brain regions (i.e., Parieto-Frontal Integration Theory, P-FIT)...


    pub_type: 杂志文章


    authors: Kim DJ,Davis EP,Sandman CA,Sporns O,O'Donnell BF,Buss C,Hetrick WP

    更新日期:2016-01-01 00:00:00

  • Neurodevelopmental changes in verbal working memory load-dependency: an fMRI investigation.

    abstract::Development of working memory (WM) aptitude parallels structural changes in the frontal-parietal association cortices important for performance within this cognitive domain. The cerebellum has been proposed to function in support of the postulated phonological loop component of verbal WM, and along with frontal and pa...


    pub_type: 杂志文章


    authors: O'Hare ED,Lu LH,Houston SM,Bookheimer SY,Sowell ER

    更新日期:2008-10-01 00:00:00

  • Structural and cognitive deficits in remitting and non-remitting recurrent depression: a voxel-based morphometric study.

    abstract::Remission is the optimal outcome for major depressive disorder (MDD), but many patients do not improve appreciably despite treatment with medication. Treatment-resistant patients may experience deterioration in cognitive functions. Research has reported structural abnormalities in certain brain areas that may contribu...


    pub_type: 杂志文章


    authors: Li CT,Lin CP,Chou KH,Chen IY,Hsieh JC,Wu CL,Lin WC,Su TP

    更新日期:2010-03-01 00:00:00

  • Decreased structural connectivity and resting-state brain activity in the lateral occipital cortex is associated with social communication deficits in boys with autism spectrum disorder.

    abstract::Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by atypical social communication and repetitive behaviors. In this study, we applied a multimodal approach to investigate brain structural connectivity, resting state activity, and surface area, as well as their associations with t...


    pub_type: 杂志文章


    authors: Jung M,Tu Y,Lang CA,Ortiz A,Park J,Jorgenson K,Kong XJ,Kong J

    更新日期:2019-04-15 00:00:00

  • Variability of the BOLD response over time: an examination of within-session differences.

    abstract::Model-based analysis methods for fMRI data assume a priori knowledge of the time course of the hemodynamic response (HR) in reaction to experimental stimuli or events. This knowledge is incorporated into the hemodynamic response function (HRF), which is a common model of the HR. Although it is already known that the H...


    pub_type: 杂志文章


    authors: Menz MM,Neumann J,Müller K,Zysset S

    更新日期:2006-09-01 00:00:00

  • Neural correlates of experimentally induced flow experiences.

    abstract::Flow refers to a positive, activity-associated, subjective experience under conditions of a perceived fit between skills and task demands. Using functional magnetic resonance perfusion imaging, we investigated the neural correlates of flow in a sample of 27 human subjects. Experimentally, in the flow condition partici...


    pub_type: 杂志文章


    authors: Ulrich M,Keller J,Hoenig K,Waller C,Grön G

    更新日期:2014-02-01 00:00:00

  • Reprint of 'A Comprehensive review of group level model performance in the presence of heteroscedasticity: Can a single model control Type I errors in the presence of outliers?'

    abstract::Even after thorough preprocessing and a careful time series analysis of functional magnetic resonance imaging (fMRI) data, artifact and other issues can lead to violations of the assumption that the variance is constant across subjects in the group level model. This is especially concerning when modeling a continuous ...


    pub_type: 杂志文章


    authors: Mumford JA

    更新日期:2017-07-01 00:00:00

  • Neurovascular coupling is impaired in cerebral microangiopathy--An event-related Stroop study.

    abstract::Small-vessel disease or cerebral microangiopathy is a common finding in elderly people leading finally to subcortical ischemic vascular dementia. Because cerebral microangiopathy impairs vascular reactivity and affects mainly the frontal lobes, we hypothesized that brain activation decreases during an event-related co...


    pub_type: 杂志文章


    authors: Schroeter ML,Cutini S,Wahl MM,Scheid R,Yves von Cramon D

    更新日期:2007-01-01 00:00:00

  • Cognitive emotion regulation enhances aversive prediction error activity while reducing emotional responses.

    abstract::Cognitive emotion regulation is a powerful way of modulating emotional responses. However, despite the vital role of emotions in learning, it is unknown whether the effect of cognitive emotion regulation also extends to the modulation of learning. Computational models indicate prediction error activity, typically obse...


    pub_type: 杂志文章


    authors: Mulej Bratec S,Xie X,Schmid G,Doll A,Schilbach L,Zimmer C,Wohlschläger A,Riedl V,Sorg C

    更新日期:2015-12-01 00:00:00

  • Measurement of GABAA receptor binding in vivo with [11C]flumazenil: a test-retest study in healthy subjects.

    abstract::[(11)C]Flumazenil is widely used in positron emission tomography (PET) studies to measure GABA(A) receptors in vivo in humans. Although several different methods have been applied for the quantification of [(11)C]flumazenil binding, the reproducibility of these methods has not been previously examined. The reproducibi...


    pub_type: 杂志文章


    authors: Salmi E,Aalto S,Hirvonen J,Långsjö JW,Maksimow AT,Oikonen V,Metsähonkala L,Virkkala J,Någren K,Scheinin H

    更新日期:2008-06-01 00:00:00

  • Layer-specific response properties of the human lateral geniculate nucleus and superior colliculus.

    abstract::The human LGN and SC consist of distinct layers, but their layer-specific response properties remain poorly understood. In this fMRI study, we characterized visual response properties of the magnocellular (M) and parvocellular (P) layers of the human LGN, as well as at different depths in the SC. Results show that fMR...


    pub_type: 杂志文章


    authors: Zhang P,Zhou H,Wen W,He S

    更新日期:2015-05-01 00:00:00

  • A general Bayesian treatment for MEG source reconstruction incorporating lead field uncertainty.

    abstract::There is uncertainty introduced when a cortical surface based model derived from an anatomical MRI is used to reconstruct neural activity with MEG data. This is a specific case of a problem with uncertainty in parameters on which M/EEG lead fields depend non-linearly. Here we present a general mathematical treatment o...


    pub_type: 杂志文章


    authors: López JD,Penny WD,Espinosa JJ,Barnes GR

    更新日期:2012-04-02 00:00:00

  • Supervoxel-based statistical analysis of diffusion tensor imaging in schizotypal personality disorder.

    abstract::To study white matter changes in schizotypal personality disorder (SPD), we developed a new statistical analysis method based on supervoxels for diffusion tensor imaging. Twenty patients with SPD and eighteen healthy controls were recruited from a pool of 3000 first-year university undergraduates, and underwent MRI us...


    pub_type: 杂志文章


    authors: Zhang T,Wang D,Zhang Q,Wu J,Lv J,Shi L

    更新日期:2017-12-01 00:00:00

  • Disrupted cortico-cerebellar connectivity in older adults.

    abstract::Healthy aging is marked by declines in a variety of cognitive and motor abilities. A better understanding of the aging brain may aid in elucidating the neural substrates of these behavioral effects. Investigations of resting state functional brain connectivity have provided insights into pathology, and to some degree,...


    pub_type: 杂志文章


    authors: Bernard JA,Peltier SJ,Wiggins JL,Jaeggi SM,Buschkuehl M,Fling BW,Kwak Y,Jonides J,Monk CS,Seidler RD

    更新日期:2013-12-01 00:00:00

  • Mood-dependent integration in discourse comprehension: happy and sad moods affect consistency processing via different brain networks.

    abstract::According to recent research on language comprehension, the semantic features of a text are not the only determinants of whether incoming information is understood as consistent. Listeners' pre-existing affective states play a crucial role as well. The current fMRI experiment examines the effects of happy and sad mood...


    pub_type: 杂志文章,随机对照试验


    authors: Egidi G,Caramazza A

    更新日期:2014-12-01 00:00:00

  • The causal role of prefrontal hemispheric asymmetry in valence processing of words - Insights from a combined cTBS-MEG study.

    abstract::Hemispheric asymmetries play an important role in multiple cerebral functions. Asymmetries in prefrontal cortex (PFC) function have been suggested to regulate emotional processing in that right-hemispheric dominance biases towards negative affect, whereas left PFC dominance favors positive affect. This study used tran...


    pub_type: 杂志文章


    authors: Roesmann K,Dellert T,Junghoefer M,Kissler J,Zwitserlood P,Zwanzger P,Dobel C

    更新日期:2019-05-01 00:00:00

  • Paired pulse depression in the somatosensory cortex: associations between MEG and BOLD fMRI.

    abstract::Interpretation of the blood oxygen level dependent (BOLD) response measured using functional magnetic resonance imaging (fMRI) requires an understanding of the underlying neuronal activity. Here we report on a study using both magnetoencephalography (MEG) and BOLD fMRI, to measure the brain's functional response to el...


    pub_type: 杂志文章


    authors: Stevenson CM,Wang F,Brookes MJ,Zumer JM,Francis ST,Morris PG

    更新日期:2012-02-01 00:00:00