Abstract:
:Functional ultrasound imaging is a method recently developed to assess brain activity via hemodynamics in rodents. Doppler ultrasound signals allow the measurement of cerebral blood volume (CBV) and red blood cells' (RBCs') velocity in small vessels. However, this technique originally requires performing a large craniotomy that limits its use to acute experiments only. Moreover, a detailed description of the hemodynamic changes that underlie functional ultrasound imaging has not been described but is essential for a better interpretation of neuroimaging data. To overcome the limitation of the craniotomy, we developed a dedicated thinned skull surgery for chronic imaging. This procedure did not induce brain inflammation nor neuronal death as confirmed by immunostaining. We successfully acquired both high-resolution images of the microvasculature and functional movies of the brain hemodynamics on the same animal at 0, 2, and 7 days without loss of quality. Then, we investigated the spatiotemporal evolution of the CBV hemodynamic response function (HRF) in response to sensory-evoked electrical stimulus (1 mA) ranging from 1 (200 μs) to 25 pulses (5s). Our results indicate that CBV HRF parameters such as the peak amplitude, the time to peak, the full width at half-maximum and the spatial extent of the activated area increase with stimulus duration. Functional ultrasound imaging was sensitive enough to detect hemodynamic responses evoked by only a single pulse stimulus. We also observed that the RBC velocity during activation could be separated in two distinct speed ranges with the fastest velocities located in the upper part of the cortex and slower velocities in deeper layers. For the first time, functional ultrasound imaging demonstrates its potential to image brain activity chronically in small animals and offers new insights into the spatiotemporal evolution of cerebral hemodynamics.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Urban A,Mace E,Brunner C,Heidmann M,Rossier J,Montaldo Gdoi
10.1016/j.neuroimage.2014.06.063subject
Has Abstractpub_date
2014-11-01 00:00:00pages
138-49eissn
1053-8119issn
1095-9572pii
S1053-8119(14)00540-0journal_volume
101pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract::The effects of age on functional connectivity (FC) of intrinsic connectivity networks (ICNs) have largely been derived from cross-sectional studies. Far less is known about longitudinal changes in FC and how they relate to ageing-related cognitive decline. We evaluated intra- and inter-network FC in 78 healthy older a...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.03.029
更新日期:2016-06-01 00:00:00
abstract::Anticipatory anxiety is a complex combination of a future-oriented cognitive state, negative affect, and autonomic arousal. A dual-task paradigm of anticipation of electric shocks and a motor-learning task was used to examine the changes in neural patterns of activation associated with modulation of the cognitive stat...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1006/nimg.1999.0407
更新日期:1999-06-01 00:00:00
abstract::Age-related impairments in the default network (DN) have been related to disruptions in connecting white matter tracts. We hypothesized that the local correlation between DN structural and functional connectivity is negatively affected in the presence of global white matter injury. In 125 clinically normal older adult...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.05.054
更新日期:2015-08-15 00:00:00
abstract::Bidirectional integration between sensory stimuli and contextual framing is fundamental to action control. Stimuli may entail context-dependent actions, while temporal or spatial characteristics of a stimulus train may establish a contextual framework for upcoming stimuli. Here we aimed at identifying core areas for s...
journal_title:NeuroImage
pub_type: 杂志文章,meta分析
doi:10.1016/j.neuroimage.2012.02.037
更新日期:2012-05-01 00:00:00
abstract::We have examined the cerebral structures involved in motor imagery of normal and precision gait (i.e., gait requiring precise foot placement and increased postural control). We recorded cerebral activity with functional magnetic resonance imaging while subjects imagined walking along paths of two different widths (bro...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.03.020
更新日期:2008-07-01 00:00:00
abstract::Task-induced decreases in blood flow and the widespread use of "resting" baselines produced unexpected and discrepant results in early cognitive imaging studies, especially in language comprehension experiments. Here I describe from a personal perspective some of the events and thought processes leading to the first h...
journal_title:NeuroImage
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neuroimage.2011.09.026
更新日期:2012-08-15 00:00:00
abstract::In this paper we demonstrate a simulation framework that enables the direct and quantitative comparison of post-processing methods for diffusion weighted magnetic resonance (DW-MR) images. DW-MR datasets are employed in a range of techniques that enable estimates of local microstructure and global connectivity in the ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.11.006
更新日期:2016-01-15 00:00:00
abstract::Recent evidence indicates subject-specific gyral folding patterns and white matter anisotropy uniquely shape electric fields generated by TMS. Current methods for predicting the brain regions influenced by TMS involve projecting the TMS coil position or center of gravity onto realistic head models derived from structu...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.04.067
更新日期:2013-11-01 00:00:00
abstract::Various neuroimaging measures are being evaluated for tracking Alzheimer's disease (AD) progression in therapeutic trials, including measures of structural brain change based on repeated scanning of patients with magnetic resonance imaging (MRI). Methods to compute brain change must be robust to scan quality. Biases m...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.10.086
更新日期:2013-02-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) in animal models provides a platform for more extensive investigation of drug effects and underlying physiological mechanisms than is possible in humans. However, it is usually necessary for the animal to be anesthetized. In this study, we have used a rat model of direct co...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.08.011
更新日期:2005-01-01 00:00:00
abstract::Anatomical and functional MRI images were acquired in a group of healthy elderly subjects (n = 11) and a group of patients diagnosed with probable Alzheimer's disease, from mild to moderate severity (n = 8). During functional sessions, verbal episodic Encoding and Recognition tasks were presented to subjects. Both gro...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.10.045
更新日期:2005-03-01 00:00:00
abstract::Brain oscillations are supposedly crucial for normal cognitive functioning and alterations are associated with cognitive dysfunctions. To demonstrate their causal role on behavior, entrainment approaches in particular aim at driving endogenous oscillations via rhythmic stimulation. Within this context, transcranial el...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.06.026
更新日期:2015-09-01 00:00:00
abstract::We investigated neural correlates of retrieval success for music memory using event-related functional magnetic resonance imaging. To minimize the interference from MRI scan noise, we used sparse temporal sampling technique. Newly composed music materials were employed as stimuli, which enabled us to detect regions in...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.08.024
更新日期:2008-01-01 00:00:00
abstract::During reinforcement learning, phasic modulations of activity in midbrain dopamine neurons are conveyed to the dorsal anterior cingulate cortex (dACC) and basal ganglia (BG) and serve to guide adaptive responding. While the animal literature supports a role for the dACC in integrating reward history over time, most hu...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.05.032
更新日期:2008-08-15 00:00:00
abstract::We imaged fast optical changes associated with evoked neural activation in the dorsal brainstem of anesthetized rats, using a novel imaging device. The imager consisted of a gradient-index (GRIN) lens, a microscope objective, and a miniature charged-coupled device (CCD) video camera. We placed the probe in contact wit...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2001.0897
更新日期:2001-11-01 00:00:00
abstract::To evaluate the relative role of left and right hemispheres (RH) and describe the functional anatomy of RH during ortholinguistic tasks, we re-analyzed the 128 papers of a former left-hemisphere (LH) meta-analysis (Vigneau et al., 2006). Of these, 59 articles reported RH participation, providing 105 RH language contra...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.07.036
更新日期:2011-01-01 00:00:00
abstract::Both higher magnetic field strengths (> or =3 T) and multiple receiver "array coils" can provide increased signal-to-noise ratio (SNR) for MRI. This increase in SNR can be used to obtain images with higher resolution, enabling better visualisation of structures within the human brain. However, high field strength syst...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.04.191
更新日期:2006-09-01 00:00:00
abstract::Cortical activation during arithmetic calculation (silent subtraction by sevens) was compared to that observed during a control condition for which subjects were required to count forward by ones. Nine normal subjects underwent 1.5-T functional magnetic resonance imaging while performing these tasks. All subjects show...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.1996.0011
更新日期:1996-04-01 00:00:00
abstract::Complex network analyses of functional connectivity have consistently revealed non-random (modular, small-world, scale-free-like) behavior of hard-thresholded networks constructed from the right-tail of the similarity histogram. In the present study we determined network properties resulting from edges constrained to ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.12.047
更新日期:2011-04-01 00:00:00
abstract::Complex tasks often require the memory of recent events, the knowledge about the context in which they occur, and the goals we intend to reach. All this information is stored in our mental states. Given a set of mental states, reinforcement learning (RL) algorithms predict the optimal policy that maximizes future rewa...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.01.047
更新日期:2010-09-01 00:00:00
abstract::In this study, we examined the impact of goal-directed processing on the response to emotional pictures and the impact of emotional pictures on goal-directed processing. Subjects (N=22) viewed neutral or emotional pictures in the presence or absence of a demanding cognitive task. Goal-directed processing disrupted the...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.11.048
更新日期:2007-03-01 00:00:00
abstract::Hearing loss is associated with difficulties in understanding speech, especially under adverse listening conditions. In these situations, seeing the speaker improves speech intelligibility in hearing-impaired participants. On the neuronal level, previous research has shown cross-modal plastic reorganization in the aud...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.04.023
更新日期:2018-07-15 00:00:00
abstract::Previous studies suggest that spontaneous fluctuations in the resting-state fMRI (RS-fMRI) signal may reflect fluctuations in transverse relaxation time (T(2)(*)) rather than spin density (S(0)). However, such S(0) and T(2)(*) features have not been well characterized. In this study, spatial and spectral characteristi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.11.030
更新日期:2012-02-15 00:00:00
abstract:MOTIVATION:Many clinical and scientific conclusions that rely on voxel-wise analyses of neuroimaging depend on the accurate comparison of corresponding anatomical regions. Such comparisons are made possible by registration of the images of subjects of interest onto a common brain template, such as the Johns Hopkins Uni...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117657
更新日期:2020-12-15 00:00:00
abstract::Interpretation of the blood oxygen level dependent (BOLD) response measured using functional magnetic resonance imaging (fMRI) requires an understanding of the underlying neuronal activity. Here we report on a study using both magnetoencephalography (MEG) and BOLD fMRI, to measure the brain's functional response to el...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.10.037
更新日期:2012-02-01 00:00:00
abstract::Normal ageing is accompanied by a progressive decline in cognitive function but the mechanisms for this are not fully understood. Nevertheless, the importance of white matter degeneration is supported by diffusion tensor imaging (DTI) studies, although several important questions remain about the pattern and nature of...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.02.033
更新日期:2010-06-01 00:00:00
abstract::Connectivity and network analysis in neuroscience has been applied to multiple spatial scales, but the links between these different scales have rarely been investigated. In tumor-related epilepsy, altered network topology is related to behavior, but the molecular basis of these observations is unknown. We elucidate t...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.02.067
更新日期:2013-07-15 00:00:00
abstract::This paper introduces neurite orientation dispersion and density imaging (NODDI), a practical diffusion MRI technique for estimating the microstructural complexity of dendrites and axons in vivo on clinical MRI scanners. Such indices of neurites relate more directly to and provide more specific markers of brain tissue...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.03.072
更新日期:2012-07-16 00:00:00
abstract::Connectome mapping using techniques such as functional magnetic resonance imaging (fMRI) has become a focus of systems neuroscience. There remain many statistical challenges in analysis of functional connectivity and network architecture from BOLD fMRI multivariate time series. One key statistic for any time series is...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.04.052
更新日期:2016-11-15 00:00:00
abstract::We evaluated the source distribution of benign rolandic spikes of childhood along and across the central sulcus in 15 patients, aged between 7 and 15 years, who suffered from seizure disorders. Previous routine EEG showed centrotemporal spikes, but none of them had major abnormalities on brain magnetic resonance imagi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.11.040
更新日期:2005-04-01 00:00:00