Reduced functional segregation between the default mode network and the executive control network in healthy older adults: A longitudinal study.

Abstract:

:The effects of age on functional connectivity (FC) of intrinsic connectivity networks (ICNs) have largely been derived from cross-sectional studies. Far less is known about longitudinal changes in FC and how they relate to ageing-related cognitive decline. We evaluated intra- and inter-network FC in 78 healthy older adults two or three times over a period of 4years. Using linear mixed modeling we found progressive loss of functional specialization with ageing, evidenced by a decline in intra-network FC within the executive control (ECN) and default mode networks (DMN). In contrast, longitudinal inter-network FC between ECN and DMN showed a u-shaped trajectory whereby functional segregation between these two networks initially increased over time and later decreased as participants aged. The rate of loss in functional segregation between ECN and DMN was associated with ageing-related decline in processing speed. The observed longitudinal FC changes and their associations with processing speed remained after correcting for longitudinal reduction in gray matter volume. These findings help connect ageing-related changes in FC with ageing-related decline in cognitive performance and underscore the value of collecting concurrent longitudinal imaging and behavioral data.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Ng KK,Lo JC,Lim JKW,Chee MWL,Zhou J

doi

10.1016/j.neuroimage.2016.03.029

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

321-330

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(16)00234-2

journal_volume

133

pub_type

杂志文章
  • A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195.

    abstract::[(11)C]-(R)-PK11195 is presently the most widely used radiotracer for the monitoring of microglia activity in the central nervous system (CNS). Microglia, the resident immune cells of the brain, play a critical role in acute and chronic diseases of the central nervous system and in host defence against neoplasia. The ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2007.02.017

    authors: Anderson AN,Pavese N,Edison P,Tai YF,Hammers A,Gerhard A,Brooks DJ,Turkheimer FE

    更新日期:2007-05-15 00:00:00

  • Increased sensitivity to age-related differences in brain functional connectivity during continuous multiple object tracking compared to resting-state.

    abstract::Age-related differences in cognitive agility vary greatly between individuals and cognitive functions. This heterogeneity is partly mirrored in individual differences in brain network connectivity as revealed using resting-state functional magnetic resonance imaging (fMRI), suggesting potential imaging biomarkers for ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2017.01.048

    authors: Dørum ES,Kaufmann T,Alnæs D,Andreassen OA,Richard G,Kolskår KK,Nordvik JE,Westlye LT

    更新日期:2017-03-01 00:00:00

  • Magnetic resonance imaging of the Amine-Proton EXchange (APEX) dependent contrast.

    abstract::Chemical exchange between water and labile protons from amino-acids, proteins and other molecules can be exploited to provide tissue contrast with magnetic resonance imaging (MRI) techniques. Using an off-resonance Spin-Locking (SL) scheme for signal preparation is advantageous because the image contrast can be tuned ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2011.08.014

    authors: Jin T,Wang P,Zong X,Kim SG

    更新日期:2012-01-16 00:00:00

  • Brain activity across the development of automatic categorization: a comparison of categorization tasks using multi-voxel pattern analysis.

    abstract::Previous evidence suggests that relatively separate neural networks underlie initial learning of rule-based and information-integration categorization tasks. With the development of automaticity, categorization behavior in both tasks becomes increasingly similar and exclusively related to activity in cortical regions....

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2013.01.008

    authors: Soto FA,Waldschmidt JG,Helie S,Ashby FG

    更新日期:2013-05-01 00:00:00

  • Neural systems mediating recognition of changes in statistical regularities.

    abstract::Neuroimaging research has identified several brain systems sensitive to statistical regularities within environmental input. However, the continuous input impinging on sensory organs is rarely stationary and its degree of regularity may itself change over time. The goals of the current fMRI study were to identify syst...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2012.08.017

    authors: Tobia MJ,Iacovella V,Davis B,Hasson U

    更新日期:2012-11-15 00:00:00

  • I am Me: Brain systems integrate and segregate to establish a multidimensional sense of self.

    abstract::Humans experience a sense of self, which is proposed to emerge from the integration of intrinsic and extrinsic self-processing through the propagation of information across brain systems. Using a novel functional magnetic resonance imaging (fMRI) paradigm, we tested this hypothesis in a non-clinical sample by modulati...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2019.116284

    authors: Di Plinio S,Perrucci MG,Aleman A,Ebisch SJH

    更新日期:2020-01-15 00:00:00

  • It takes two to tango: Suppression of task-irrelevant features requires (spatial) competition.

    abstract::In a recent electrophysiological study, we reported on global facilitation but local suppression of color stimuli in feature-based attention in human early visual cortex. Subjects attended to one of two centrally located superimposed red/blue random dot kinematograms (RDKs). Task-irrelevant single RDKs in the same col...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2018.05.073

    authors: Müller MM,Gundlach C,Forschack N,Brummerloh B

    更新日期:2018-09-01 00:00:00

  • The minimal preprocessing pipelines for the Human Connectome Project.

    abstract::The Human Connectome Project (HCP) faces the challenging task of bringing multiple magnetic resonance imaging (MRI) modalities together in a common automated preprocessing framework across a large cohort of subjects. The MRI data acquired by the HCP differ in many ways from data acquired on conventional 3 Tesla scanne...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2013.04.127

    authors: Glasser MF,Sotiropoulos SN,Wilson JA,Coalson TS,Fischl B,Andersson JL,Xu J,Jbabdi S,Webster M,Polimeni JR,Van Essen DC,Jenkinson M,WU-Minn HCP Consortium.

    更新日期:2013-10-15 00:00:00

  • Extended-release naltrexone (XR-NTX) attenuates brain responses to alcohol cues in alcohol-dependent volunteers: a bold FMRI study.

    abstract::Oral naltrexone reduces heavy drinking, but is less consistent as an abstinence promoter, whereas once-monthly extended-release naltrexone (XR-NTX) also maintains abstinence. The present study sought to determine if alcohol cue reactivity is attenuated by XR-NTX. Twenty-eight detoxified alcohol-dependent adult male an...

    journal_title:NeuroImage

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.neuroimage.2013.03.055

    authors: Lukas SE,Lowen SB,Lindsey KP,Conn N,Tartarini W,Rodolico J,Mallya G,Palmer C,Penetar DM

    更新日期:2013-09-01 00:00:00

  • The event-related optical signal to electrical stimulation of the median nerve.

    abstract::The event-related optical signal (EROS) uses near-infrared light to study changes in neuronal optical properties in response to stimuli and endogenous events. EROS responses to electrical stimulation of the median nerve at 1, 5, and 8 Hz were collected from 80 channels in 7 subjects. Optical recording channels were sp...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2003.11.019

    authors: Maclin EL,Low KA,Sable JJ,Fabiani M,Gratton G

    更新日期:2004-04-01 00:00:00

  • Prefrontal activity during taste encoding: an fNIRS study.

    abstract::To elucidate the function of the lateral prefrontal cortex (LPFC) in taste encoding, it is worth applying to taste, the psychological paradigms of intentional memorization that have been used with other extensively studied senses, and thus updating current models for LPFC functions to include a taste modality. Using m...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2005.12.021

    authors: Okamoto M,Matsunami M,Dan H,Kohata T,Kohyama K,Dan I

    更新日期:2006-06-01 00:00:00

  • Friends, not foes: Magnetoencephalography as a tool to uncover brain dynamics during transcranial alternating current stimulation.

    abstract::Brain oscillations are supposedly crucial for normal cognitive functioning and alterations are associated with cognitive dysfunctions. To demonstrate their causal role on behavior, entrainment approaches in particular aim at driving endogenous oscillations via rhythmic stimulation. Within this context, transcranial el...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2015.06.026

    authors: Neuling T,Ruhnau P,Fuscà M,Demarchi G,Herrmann CS,Weisz N

    更新日期:2015-09-01 00:00:00

  • Differential contributions of the globus pallidus and ventral thalamus to stimulus-response learning in humans.

    abstract::The ability to learn associations between stimuli, responses and rewards is a prerequisite for survival. Models of reinforcement learning suggest that the striatum, a basal ganglia input nucleus, vitally contributes to these learning processes. Our recently presented computational model predicts, first, that not only ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2015.07.061

    authors: Schroll H,Horn A,Gröschel C,Brücke C,Lütjens G,Schneider GH,Krauss JK,Kühn AA,Hamker FH

    更新日期:2015-11-15 00:00:00

  • Functional connectivity dynamics: modeling the switching behavior of the resting state.

    abstract::Functional connectivity (FC) sheds light on the interactions between different brain regions. Besides basic research, it is clinically relevant for applications in Alzheimer's disease, schizophrenia, presurgical planning, epilepsy, and traumatic brain injury. Simulations of whole-brain mean-field computational models ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2014.11.001

    authors: Hansen EC,Battaglia D,Spiegler A,Deco G,Jirsa VK

    更新日期:2015-01-15 00:00:00

  • Functional disconnection of associative cortical areas predicts performance during BCI training.

    abstract::Brain-computer interfaces (BCIs) have been largely developed to allow communication, control, and neurofeedback in human beings. Despite their great potential, BCIs perform inconsistently across individuals and the neural processes that enable humans to achieve good control remain poorly understood. To address this qu...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2019.116500

    authors: Corsi MC,Chavez M,Schwartz D,George N,Hugueville L,Kahn AE,Dupont S,Bassett DS,De Vico Fallani F

    更新日期:2020-04-01 00:00:00

  • Neurometabolic underpinning of the intergenerational transmission of prosociality.

    abstract::Parent-child personality transmission can occur via biological gene-driven processes as well as through environmental factors such as shared environment and parenting style. We recently revealed a negative association between prosociality, a highly valued personality attribute in human society, and anterior cingulate ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2020.116965

    authors: Okada N,Yahata N,Koshiyama D,Morita K,Sawada K,Kanata S,Fujikawa S,Sugimoto N,Toriyama R,Masaoka M,Koike S,Araki T,Kano Y,Endo K,Yamasaki S,Ando S,Nishida A,Hiraiwa-Hasegawa M,Edden RAE,Sawa A,Kasai K

    更新日期:2020-09-01 00:00:00

  • Modelling and interpretation of magnetization transfer imaging in the brain.

    abstract::Magnetization transfer contrast has yielded insight into brain tissue microstructure changes across the lifespan and in a range of disorders. This progress has been aided by the development of quantitative magnetization transfer imaging techniques able to extract intrinsic properties of the tissue that are independent...

    journal_title:NeuroImage

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroimage.2017.11.065

    authors: Sled JG

    更新日期:2018-11-15 00:00:00

  • Competing against a familiar friend: Interactive mechanism of the temporo-parietal junction with the reward-related regions during episodic encoding.

    abstract::Competition enhances learning under certain circumstances. However, little is known about how the neural mechanisms involved in a competition during the episodic encoding are modulated by the social distance of personal relationships with opponents. To investigate this issue, using functional magnetic resonance imagin...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2016.02.020

    authors: Sugimoto H,Shigemune Y,Tsukiura T

    更新日期:2016-04-15 00:00:00

  • Basal ganglia are active during motor performance recovery after a demanding motor task.

    abstract::Motor performance recovery after a demanding finger motor task does not follow the excitability dynamics of primary motor cortex (M1), which remains depressed also when performance is restored. Thus, other neural circuits are supposed to cope with central fatigue, re-establishing adequate motor performance levels. A h...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2012.10.012

    authors: Bonzano L,Tacchino A,Saitta L,Roccatagliata L,Avanzino L,Mancardi GL,Bove M

    更新日期:2013-01-15 00:00:00

  • Single-trial coupling of EEG and fMRI reveals the involvement of early anterior cingulate cortex activation in effortful decision making.

    abstract::While the precise role of the anterior cingulate cortex (ACC) is still being discussed, it has been suggested that ACC activity might reflect the amount of mental effort associated with cognitive processing. So far, not much is known about the temporal dynamics of ACC activity in effort-related decision making or audi...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2008.04.236

    authors: Mulert C,Seifert C,Leicht G,Kirsch V,Ertl M,Karch S,Moosmann M,Lutz J,Möller HJ,Hegerl U,Pogarell O,Jäger L

    更新日期:2008-08-01 00:00:00

  • Patterns of resting state connectivity in human primary visual cortical areas: a 7T fMRI study.

    abstract::The nature and origin of fMRI resting state fluctuations and connectivity are still not fully known. More detailed knowledge on the relationship between resting state patterns and brain function may help to elucidate this matter. We therefore performed an in depth study of how resting state fluctuations map to the wel...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2013.09.060

    authors: Raemaekers M,Schellekens W,van Wezel RJ,Petridou N,Kristo G,Ramsey NF

    更新日期:2014-01-01 00:00:00

  • 'Whose atlas I use, his song I sing?' - The impact of anatomical atlases on fiber tract contributions to cognitive deficits after stroke.

    abstract::Nowadays, different anatomical atlases exist for the anatomical interpretation of the results from neuroimaging and lesion analysis studies that investigate the contribution of white matter fiber tract integrity to cognitive (dys)function. A major problem with the use of different atlases in different studies, however...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2017.09.051

    authors: de Haan B,Karnath HO

    更新日期:2017-12-01 00:00:00

  • Cortical functional connectivity indexes arousal state during sleep and anesthesia.

    abstract::Disruption of cortical connectivity likely contributes to loss of consciousness (LOC) during both sleep and general anesthesia, but the degree of overlap in the underlying mechanisms is unclear. Both sleep and anesthesia comprise states of varying levels of arousal and consciousness, including states of largely mainta...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2020.116627

    authors: Banks MI,Krause BM,Endemann CM,Campbell DI,Kovach CK,Dyken ME,Kawasaki H,Nourski KV

    更新日期:2020-05-01 00:00:00

  • Retrieved emotional context influences hippocampal involvement during recognition of neutral memories.

    abstract::It is well documented that emotionally arousing experiences are better remembered than mundane events. This is thought to occur through hippocampus-amygdala crosstalk during encoding, consolidation, and retrieval. Here we investigated whether emotional events (context) also cause a memory benefit for simultaneously en...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2016.08.069

    authors: Takashima A,van der Ven F,Kroes MC,Fernández G

    更新日期:2016-12-01 00:00:00

  • The impact of serotonin transporter (5-HTTLPR) genotype on the development of resting-state functional connectivity in children and adolescents: a preliminary report.

    abstract::A fundamental component of brain development is the formation of large-scale networks across the cortex. One such network, the default network, undergoes a protracted development, displaying weak connectivity in childhood that strengthens in adolescence and becomes most robust in adulthood. Little is known about the g...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2011.10.030

    authors: Wiggins JL,Bedoyan JK,Peltier SJ,Ashinoff S,Carrasco M,Weng SJ,Welsh RC,Martin DM,Monk CS

    更新日期:2012-02-01 00:00:00

  • The eye as a window to the listening brain: neural correlates of pupil size as a measure of cognitive listening load.

    abstract::An important aspect of hearing is the degree to which listeners have to deploy effort to understand speech. One promising measure of listening effort is task-evoked pupil dilation. Here, we use functional magnetic resonance imaging (fMRI) to identify the neural correlates of pupil dilation during comprehension of degr...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2014.06.069

    authors: Zekveld AA,Heslenfeld DJ,Johnsrude IS,Versfeld NJ,Kramer SE

    更新日期:2014-11-01 00:00:00

  • Cytoarchitectural differences are a key determinant of laminar projection origins in the visual cortex.

    abstract::Regularity of laminar origin and termination of projections appears to be a common feature of corticocortical connections. We tested three models of this regularity, originally formulated for primate cerebral cortex, using quantitative data on the relative supragranular layer origins (SGN%) of 151 projections from 19 ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2010.03.006

    authors: Hilgetag CC,Grant S

    更新日期:2010-07-01 00:00:00

  • Development of a novel robust measure for interhemispheric synchrony in the neonatal EEG: activation synchrony index (ASI).

    abstract::The degree of interhemispheric synchrony in the neonatal EEG assessment refers to the co-occurrence of activity bouts during quiet sleep or burst suppression, and it has been widely considered as a key component in assessing background activity. However, no objective measures have been published for measuring it, and ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2012.12.017

    authors: Räsänen O,Metsäranta M,Vanhatalo S

    更新日期:2013-04-01 00:00:00

  • Combined MEG and EEG show reliable patterns of electromagnetic brain activity during natural viewing.

    abstract::Naturalistic stimuli such as movies are increasingly used to engage cognitive and emotional processes during fMRI of brain hemodynamic activity. However, movies have been little utilized during magnetoencephalography (MEG) and EEG that directly measure population-level neuronal activity at a millisecond resolution. He...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2015.03.066

    authors: Chang WT,Jääskeläinen IP,Belliveau JW,Huang S,Hung AY,Rossi S,Ahveninen J

    更新日期:2015-07-01 00:00:00

  • Voxel-based diffusion tensor imaging in patients with mesial temporal lobe epilepsy and hippocampal sclerosis.

    abstract:BACKGROUND:Mesial temporal lobe epilepsy (mTLE) with hippocampus sclerosis (HS) is an important cause for focal epilepsy. In this study, we explored the integrity of connecting networks using diffusion tensor imaging (DTI) and two whole-brain voxel-based methods: statistical parametric mapping (SPM) and tract-based spa...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2007.12.031

    authors: Focke NK,Yogarajah M,Bonelli SB,Bartlett PA,Symms MR,Duncan JS

    更新日期:2008-04-01 00:00:00