Abstract:
:Age-related differences in cognitive agility vary greatly between individuals and cognitive functions. This heterogeneity is partly mirrored in individual differences in brain network connectivity as revealed using resting-state functional magnetic resonance imaging (fMRI), suggesting potential imaging biomarkers for age-related cognitive decline. However, although convenient in its simplicity, the resting state is essentially an unconstrained paradigm with minimal experimental control. Here, based on the conception that the magnitude and characteristics of age-related differences in brain connectivity is dependent on cognitive context and effort, we tested the hypothesis that experimentally increasing cognitive load boosts the sensitivity to age and changes the discriminative network configurations. To this end, we obtained fMRI data from younger (n=25, mean age 24.16±5.11) and older (n=22, mean age 65.09±7.53) healthy adults during rest and two load levels of continuous multiple object tracking (MOT). Brain network nodes and their time-series were estimated using independent component analysis (ICA) and dual regression, and the edges in the brain networks were defined as the regularized partial temporal correlations between each of the node pairs at the individual level. Using machine learning based on a cross-validated regularized linear discriminant analysis (rLDA) we attempted to classify groups and cognitive load from the full set of edge-wise functional connectivity indices. While group classification using resting-state data was highly above chance (approx. 70% accuracy), functional connectivity (FC) obtained during MOT strongly increased classification performance, with 82% accuracy for the young and 95% accuracy for the old group at the highest load level. Further, machine learning revealed stronger differentiation between rest and task in young compared to older individuals, supporting the notion of network dedifferentiation in cognitive aging. Task-modulation in edgewise FC was primarily observed between attention- and sensorimotor networks; with decreased negative correlations between attention- and default mode networks in older adults. These results demonstrate that the magnitude and configuration of age-related differences in brain functional connectivity are partly dependent on cognitive context and load, which emphasizes the importance of assessing brain connectivity differences across a range of cognitive contexts beyond the resting-state.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Dørum ES,Kaufmann T,Alnæs D,Andreassen OA,Richard G,Kolskår KK,Nordvik JE,Westlye LTdoi
10.1016/j.neuroimage.2017.01.048subject
Has Abstractpub_date
2017-03-01 00:00:00pages
364-372eissn
1053-8119issn
1095-9572pii
S1053-8119(17)30057-5journal_volume
148pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract::We evaluate the impact of template choice on template-based segmentation of the hippocampus in epilepsy. Four dataset-specific strategies are quantitatively contrasted: the "closest to average" individual template, the average shape version of the closest to average template, a best appearance template and the best ap...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.09.062
更新日期:2010-02-01 00:00:00
abstract::The impact of in-scanner motion on functional magnetic resonance imaging (fMRI) data has a notorious reputation in the neuroimaging community. State-of-the-art guidelines advise to scrub out excessively corrupted frames as assessed by a composite framewise displacement (FD) score, to regress out models of nuisance var...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116433
更新日期:2020-04-01 00:00:00
abstract::The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for speed of signal conduction, cellular energetics, and spatial constraints. In vivo imaging of the g-ratio in health and disease woul...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2017.08.038
更新日期:2018-11-15 00:00:00
abstract::Temporal processing underlies many aspects of human perception, performance and cognition. The present study used fMRI to examine the functional neuroanatomy of a temporal discrimination task and to address two questions highlighted by previous studies: (1) the effect of task difficulty on neuronal activation and (2) ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.02.036
更新日期:2006-08-01 00:00:00
abstract::Brain imaging studies in TEP, functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) have shown that visuospatial short-term memory tasks depend on dorsal parietofrontal networks. Knowing the spatiotemporal dynamics of this network would provide further understanding of the neural bases of the e...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2003.10.052
更新日期:2004-11-01 00:00:00
abstract::According to a classical view of visual object recognition, targets are detected "pre-attentively" if they carry unique features, whereas attention has to be deployed serially to object locations for feature binding if the targets can be distinguished from distracters only in terms of their feature conjunctions. Consi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2001.0951
更新日期:2002-01-01 00:00:00
abstract::(R)-[11C]PK11195 has been used for quantifying cerebral microglial activation in vivo. In previous studies, both plasma input and reference tissue methods have been used, usually in combination with a region of interest (ROI) approach. Definition of ROIs, however, can be labourious and prone to interobserver variation...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.02.013
更新日期:2007-05-01 00:00:00
abstract::In the motion aftereffect (MAE), adapting to a moving stimulus causes a subsequently presented stationary stimulus to appear to move in the opposite direction. Recently, the neural basis of the motion aftereffect has received considerable interest, and a number of brain areas have been implicated in the generation of ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.06.034
更新日期:2013-11-15 00:00:00
abstract::Subtle changes in white matter (WM) microstructure have been associated with normal aging and neurodegeneration. To study these associations in more detail, it is highly important that the WM tracts can be accurately and reproducibly characterized from brain diffusion MRI. In addition, to enable analysis of WM tracts ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.116993
更新日期:2020-09-01 00:00:00
abstract::Advances in the field of quantum sensing mean that magnetic field sensors, operating at room temperature, are now able to achieve sensitivity similar to that of cryogenically cooled devices (SQUIDs). This means that room temperature magnetoencephalography (MEG), with a greatly increased flexibility of sensor placement...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.01.034
更新日期:2017-04-01 00:00:00
abstract::Several methods exist and are frequently used to quantify grey matter (GM) atrophy in multiple sclerosis (MS). Fundamental to all available techniques is the accurate segmentation of GM in the brain, a difficult task confounded even further by the pathology present in the brains of MS patients. In this paper, we exami...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.05.029
更新日期:2010-10-01 00:00:00
abstract::Functional localizers are routinely used in neuroimaging studies to test hypotheses about the function of specific brain areas. The specific tasks and stimuli used to localize particular regions vary widely from study to study even when the same cortical region is targeted. Thus, it is important to ask whether task an...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2009.12.024
更新日期:2010-03-01 00:00:00
abstract::Interactions between the posterior parietal cortex and the early visual cortex have been proposed to play a central role in the binding of visual features into coherent objects. Here we investigated the importance of these interactions by contrasting the time windows at which the early visual cortex (V1/V2) and the an...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.08.089
更新日期:2012-01-16 00:00:00
abstract::Perception via different sensory modalities was traditionally believed to be supported by largely separate brain systems. However, a growing number of studies demonstrate that the visual cortices of typical, sighted adults are involved in tactile and auditory perceptual processing. Here, we investigated the spatiotemp...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116084
更新日期:2019-11-15 00:00:00
abstract::The effects of age on functional connectivity (FC) of intrinsic connectivity networks (ICNs) have largely been derived from cross-sectional studies. Far less is known about longitudinal changes in FC and how they relate to ageing-related cognitive decline. We evaluated intra- and inter-network FC in 78 healthy older a...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.03.029
更新日期:2016-06-01 00:00:00
abstract::The "language-ready" brain theory suggests that the infant brain is pre-wired for language acquisition prior to language exposure. As a potential brain marker of such a language readiness, a leftward structural brain asymmetry was found in human infants for the Planum Temporale (PT), which overlaps with Wernicke's are...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117575
更新日期:2020-12-04 00:00:00
abstract::Repetitive head impacts represent a risk factor for neurological impairment in team-sport athletes. In the absence of symptoms, a physiological basis for acute injury has not been elucidated. A basic brain function that is disrupted after mild traumatic brain injury is the regulation of homeostasis, instantiated by ac...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117306
更新日期:2020-12-01 00:00:00
abstract::Scientific and mathematical thinking relies on the ability to evaluate whether conclusions drawn from conditional (if-then) arguments are logically valid. Yet, the neural development of this ability -- termed deductive reasoning -- is largely unknown. Here we aimed to identify the neural mechanisms that underlie the e...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.09.029
更新日期:2017-12-01 00:00:00
abstract::Canonical correlation analysis (CCA) has been used in Functional Magnetic Resonance Imaging (fMRI) for improved detection of activation by incorporating time series from multiple voxels in a local neighborhood. To improve the specificity of local CCA methods, spatial constraints were previously proposed. In this study...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.12.081
更新日期:2017-04-01 00:00:00
abstract::Theories of the positive symptoms of schizophrenia hypothesize a role for aberrant reinforcement signaling driven by dysregulated dopamine transmission. Recently, we provided evidence of aberrant reward learning in symptomatic, but not asymptomatic patients with schizophrenia, using a novel paradigm, the Salience Attr...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.11.075
更新日期:2010-04-01 00:00:00
abstract::The diffusion tensor is a commonly used model for diffusion-weighted MR image data. The parameters are typically estimated by ordinary or weighted least squares on log-transformed data, assuming normal or log-normal distribution of measurement errors respectively. This may not be adequate when using high b-values and ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.05.053
更新日期:2008-10-01 00:00:00
abstract::Anticipatory anxiety is a complex combination of a future-oriented cognitive state, negative affect, and autonomic arousal. A dual-task paradigm of anticipation of electric shocks and a motor-learning task was used to examine the changes in neural patterns of activation associated with modulation of the cognitive stat...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1006/nimg.1999.0407
更新日期:1999-06-01 00:00:00
abstract::In brain-imaging research, we are often interested in making quantitative claims about effects across subjects. Given that most imaging data consist of tens to thousands of spatially correlated time series, inter-subject comparisons are typically accomplished with simple combinations of inter-subject data, for example...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.07.064
更新日期:2008-02-01 00:00:00
abstract::Humans can flexibly alter a plan of action to adjust their behavior adaptively in changing environments. Functional neuroimaging has shown distinct patterns of activation across a frontoparietal network responsible for switching and updating such plans of action or 'task sets.' However, little is known about the tempo...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2003.10.008
更新日期:2004-02-01 00:00:00
abstract::Spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) signal, as measured by functional magnetic resonance imaging (fMRI) at rest, exhibit a temporally coherent activity thought to reflect functionally relevant networks. Antero-mesial temporal structures are the site of early pathological changes in...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.05.090
更新日期:2011-09-15 00:00:00
abstract::Pseudocontinuous arterial spin labeling (PCASL), a newly proposed perfusion magnetic resonance imaging (MRI) technique, has the potential of providing a better balance between labeling efficiency and signal-to-noise ratio than conventional ASL methods. The advantage will not be exploitable until adequate reproducibili...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.02.080
更新日期:2011-06-01 00:00:00
abstract::PET scanners devoted to in vivo functional study have recently been developed, but autoradiography remains the reference technique for assessing cerebral glucose metabolism (CMRGlu) in rodents. Autoradiographs are conventionally subjected to region of interest (ROI) analysis, which is intrinsically hypothesis-driven a...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.11.054
更新日期:2008-04-01 00:00:00
abstract::Recent advances in neuroimaging technology now permit a precise determination of the dynamics of specific neural activity underlying human associative learning. We used magnetoencephalography (MEG) to characterize the dynamics of conditioned responses (CRs) within auditory cortex during habituation, delay and trace co...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroimage.2005.05.017
更新日期:2005-10-01 00:00:00
abstract::EEG mu rhythms (8-13 Hz) recorded at fronto-central electrodes are generally considered as markers of motor cortical activity in humans, because they are modulated when participants perform an action, when they observe another's action or even when they imagine performing an action. In this study, we analyzed the time...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.01.018
更新日期:2015-04-01 00:00:00
abstract::A sequence for the fast acquisition of T1 weighted structural brain images with whole brain coverage and isotropic resolution of 1mm is presented. It is based on MDEFT with a FLASH-EPI hybrid readout. Several techniques for artefact suppression are implemented, like echo time shifting, asymmetric k-space sampling, and...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.08.005
更新日期:2006-12-01 00:00:00