当前位置： SCI文献检索 > NEUROIMAGE期刊下所有文献 > SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods.

SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods.

Abstract：

:(R)-[11C]PK11195 has been used for quantifying cerebral microglial activation in vivo. In previous studies, both plasma input and reference tissue methods have been used, usually in combination with a region of interest (ROI) approach. Definition of ROIs, however, can be labourious and prone to interobserver variation. In addition, results are only obtained for predefined areas and (unexpected) signals in undefined areas may be missed. On the other hand, standard pharmacokinetic models are too sensitive to noise to calculate (R)-[11C]PK11195 binding on a voxel-by-voxel basis. Linearised versions of both plasma input and reference tissue models have been described, and these are more suitable for parametric imaging. The purpose of this study was to compare the performance of these plasma input and reference tissue parametric methods on the outcome of statistical parametric mapping (SPM) analysis of (R)-[11C]PK11195 binding. Dynamic (R)-[11C]PK11195 PET scans with arterial blood sampling were performed in 7 younger and 11 elderly healthy subjects. Parametric images of volume of distribution (Vd) and binding potential (BP) were generated using linearised versions of plasma input (Logan) and reference tissue (Reference Parametric Mapping) models. Images were compared at the group level using SPM with a two-sample t-test per voxel, both with and without proportional scaling. Parametric BP images without scaling provided the most sensitive framework for determining differences in (R)-[11C]PK11195 binding between younger and elderly subjects. Vd images could only demonstrate differences in (R)-[11C]PK11195 binding when analysed with proportional scaling due to intersubject variation in K1/k2 (blood-brain barrier transport and non-specific binding).

journal_name

Neuroimage

journal_title

NeuroImage

authors

Schuitemaker A,van Berckel BN,Kropholler MA,Veltman DJ,Scheltens P,Jonker C,Lammertsma AA,Boellaard R

doi

10.1016/j.neuroimage.2007.02.013

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

1473-9

issue

4

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(07)00109-7

journal_volume

35

pub_type

杂志文章

相关文献

NEUROIMAGE文献大全
  • Magnetic stimulation of visual cortex impairs perceptual learning.

    abstract：:The ability to learn and process visual stimuli more efficiently is important for survival. Previous neuroimaging studies have shown that perceptual learning on a shape identification task differently modulates activity in both frontal-parietal cortical regions and visual cortex (Sigman et al., 2005;Lewis et al., 2009...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2016.08.063

    authors： Baldassarre A,Capotosto P,Committeri G,Corbetta M

    更新日期：2016-12-01 00:00:00

  • Attentional modulation of the amygdala varies with personality.

    abstract：:The amygdala is implicated in emotional processing, and its rich subcortical connections have led to suggestions that processing of emotional stimuli occurs independently of attention. Using a novel attentional manipulation in conjunction with fMRI, we showed that emotion-related amygdala activity was modulated by att...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2005.12.031

    authors： Most SB,Chun MM,Johnson MR,Kiehl KA

    更新日期：2006-06-01 00:00:00

  • Modulation of the lexical-semantic network by auditory semantic priming: an event-related functional MRI study.

    abstract：:The current event-related fMRI study specifies the neuroanatomical correlates of semantic priming and differences in semantic relation types using an auditory primed lexical decision task (LDT). Word pairs consisted of different relation types, associations (key-chain), pure categorical relations (cow-dog), and unrela...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1006/nimg.2002.1316

    authors： Kotz SA,Cappa SF,von Cramon DY,Friederici AD

    更新日期：2002-12-01 00:00:00

  • Quantitative examination of a novel clustering method using magnetic resonance diffusion tensor tractography.

    abstract：:MR diffusion tensor imaging (DTI) can measure and visualize organization of white matter fibre tracts in vivo. DTI is a relatively new imaging technique, and new tools developed for quantifying fibre tracts require evaluation. The purpose of this study was to compare the reliability of a novel clustering approach with...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2008.12.028

    authors： Voineskos AN,O'Donnell LJ,Lobaugh NJ,Markant D,Ameis SH,Niethammer M,Mulsant BH,Pollock BG,Kennedy JL,Westin CF,Shenton ME

    更新日期：2009-04-01 00:00:00

  • Shared networks for auditory and motor processing in professional pianists: evidence from fMRI conjunction.

    abstract：:To investigate cortical auditory and motor coupling in professional musicians, we compared the functional magnetic resonance imaging (fMRI) activity of seven pianists to seven non-musicians utilizing a passive task paradigm established in a previous learning study. The tasks involved either passively listening to shor...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2005.10.044

    authors： Bangert M,Peschel T,Schlaug G,Rotte M,Drescher D,Hinrichs H,Heinze HJ,Altenmüller E

    更新日期：2006-04-15 00:00:00

  • Electrophysiological correlates of remembering emotional pictures.

    abstract：:Extensive evidence shows that emotional events tend to be remembered in greater detail and with an enhanced sense of vividness compared to neutral events. The current study investigated the neural correlates of this phenomenon during retrieval using the event-related potentials technique (ERP). Participants were asked...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.07.030

    authors： Schaefer A,Pottage CL,Rickart AJ

    更新日期：2011-01-01 00:00:00

  • The cortical motor threshold reflects microstructural properties of cerebral white matter.

    abstract：:Transcranial magnetic stimulation (TMS) can be used to probe distinct aspects of excitability of the primary motor hand area (M1(Hand)). The motor threshold (MT) reflects the trans-synaptic excitability of corticospinal output neurons. The MT corresponds to the minimal intensity at which TMS evokes a contralateral mot...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2008.01.019

    authors： Klöppel S,Bäumer T,Kroeger J,Koch MA,Büchel C,Münchau A,Siebner HR

    更新日期：2008-05-01 00:00:00

  • Dual-radiotracer translational SPECT neuroimaging. Comparison of three methods for the simultaneous brain imaging of D2/3 and 5-HT2A receptors.

    abstract：PURPOSE:SPECT imaging with two radiotracers at the same time is feasible if two different radioisotopes are employed, given their distinct energy emission spectra. In the case of 123I and 125I, dual SPECT imaging is not straightforward: 123I emits photons at a principal energy emission spectrum of 143.1-179.9 keV. Howe...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.04.063

    authors： Tsartsalis S,Tournier BB,Habiby S,Ben Hamadi M,Barca C,Ginovart N,Millet P

    更新日期：2018-08-01 00:00:00

  • A comparison of morphometric techniques for studying the shape of the corpus callosum in adolescent idiopathic scoliosis.

    abstract：:The purpose of this paper is to compare volume- and boundary-based morphometry methods by applying them in the statistical analysis of 2-D shapes. The methods discussed in the first category include voxel-, deformation-, and tensor-based morphometry. The active shape model is demonstrated as an example of the second c...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2008.12.068

    authors： Wang D,Shi L,Chu WC,Paus T,Cheng JC,Heng PA

    更新日期：2009-04-15 00:00:00

  • Plasticity in the adult language system: a longitudinal electrophysiological study on second language learning.

    abstract：:Event-related potentials (ERPs) were used to trace changes in brain activity related to progress in second language learning. Twelve English-speaking exchange students learning German in Switzerland were recruited. ERPs to visually presented single words from the subjects' native language (English), second language (G...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.07.008

    authors： Stein M,Dierks T,Brandeis D,Wirth M,Strik W,Koenig T

    更新日期：2006-11-01 00:00:00

  • Unsupervised multiparametric classification of dynamic susceptibility contrast imaging: study of the healthy brain.

    abstract：:Characterization and quantification of magnetic resonance perfusion images is important for clinical interpretation, though this calls for a reproducible and accurate method of analysis and a robust healthy reference. The few studies which have examined the perfusion of the healthy brain using dynamic susceptibility c...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.03.027

    authors： Artzi M,Aizenstein O,Hendler T,Ben Bashat D

    更新日期：2011-06-01 00:00:00

  • Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment.

    abstract：:Recent research has shown an increased rate of conversion to dementia in subjects with mild cognitive impairment (MCI) compared to controls. However, there are no specific methods to predict who will later develop dementia. In the present study, 22 controls and 56 MCI subjects were followed on average for 37 months (m...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.06.016

    authors： Hämäläinen A,Tervo S,Grau-Olivares M,Niskanen E,Pennanen C,Huuskonen J,Kivipelto M,Hänninen T,Tapiola M,Vanhanen M,Hallikainen M,Helkala EL,Nissinen A,Vanninen R,Soininen H

    更新日期：2007-10-01 00:00:00

  • Regional specificity of hippocampal volume reductions in first-episode schizophrenia.

    abstract：:Hippocampal volume reductions are widely observed in schizophrenia. Some studies suggest anterior hippocampal regions are more susceptible and associated with frontal lobe dysfunctions, while others implicate posterior regions. Using high-resolution MR images and novel computational image analysis methods, we identifi...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2003.11.011

    authors： Narr KL,Thompson PM,Szeszko P,Robinson D,Jang S,Woods RP,Kim S,Hayashi KM,Asunction D,Toga AW,Bilder RM

    更新日期：2004-04-01 00:00:00

  • Errors can be related to pre-stimulus differences in ERP topography and their concomitant sources.

    abstract：:Much of the variation in both neuronal and behavioral responses to stimuli can be explained by pre-stimulus fluctuations in brain activity. We hypothesized that also errors are the result of stochastic fluctuations in pre-stimulus activity and investigated the temporal dynamics of the scalp topography and their concom...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.10.033

    authors： Britz J,Michel CM

    更新日期：2010-02-01 00:00:00

  • Phase stability in fMRI time series: effect of noise regression, off-resonance correction and spatial filtering techniques.

    abstract：:Although the majority of fMRI studies exploit magnitude changes only, there is an increasing interest regarding the potential additive information conveyed by the phase signal. This integrated part of the complex number furnished by the MR scanners can also be used for exploring direct detection of neuronal activity a...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.10.095

    authors： Hagberg GE,Bianciardi M,Brainovich V,Cassara AM,Maraviglia B

    更新日期：2012-02-15 00:00:00

  • Bilingualism at the core of the brain. Structural differences between bilinguals and monolinguals revealed by subcortical shape analysis.

    abstract：:Naturally acquiring a language shapes the human brain through a long-lasting learning and practice process. This is supported by previous studies showing that managing more than one language from early childhood has an impact on brain structure and function. However, to what extent bilingual individuals present neuroa...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.09.073

    authors： Burgaleta M,Sanjuán A,Ventura-Campos N,Sebastian-Galles N,Ávila C

    更新日期：2016-01-15 00:00:00

  • Developmental stages and sex differences of white matter and behavioral development through adolescence: a longitudinal diffusion tensor imaging (DTI) study.

    abstract：:White matter (WM) continues to mature through adolescence in parallel with gains in cognitive ability. To date, developmental changes in human WM microstructure have been inferred using analyses of cross-sectional or two time-point follow-up studies, limiting our understanding of individual developmental trajectories....

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2013.12.044

    authors： Simmonds DJ,Hallquist MN,Asato M,Luna B

    更新日期：2014-05-15 00:00:00

  • Brain MAPS: an automated, accurate and robust brain extraction technique using a template library.

    abstract：:Whole brain extraction is an important pre-processing step in neuroimage analysis. Manual or semi-automated brain delineations are labour-intensive and thus not desirable in large studies, meaning that automated techniques are preferable. The accuracy and robustness of automated methods are crucial because human exper...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.12.067

    authors： Leung KK,Barnes J,Modat M,Ridgway GR,Bartlett JW,Fox NC,Ourselin S,Alzheimer's Disease Neuroimaging Initiative.

    更新日期：2011-04-01 00:00:00

  • Distinguishing the evoked response from phase reset: a comment to Mäkinen et al.

    abstract：:Mäkinen et al. [Mäkinen, V., Tiitinen, H., May, P., 2005. Auditory event-related responses are generated independently of ongoing brain activity. Neuroimage 24, 961-968] suggest the use of amplitude variance to distinguish the evoked response from phase reset. Because their data do not exhibit a drop in amplitude vari...

    journal_title：NeuroImage

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuroimage.2005.08.041

    authors： Klimesch W,Hanslmayr S,Sauseng P,Gruber WR

    更新日期：2006-02-01 00:00:00

  • Echo-time dependence of the BOLD response transients - A window into brain functional physiology.

    abstract：:The blood oxygenation level-dependent (BOLD) fMRI response to neuronal activation results from a complex interplay of induced metabolic and vascular changes. Thus, its transients, such as initial overshoot and post-stimulus undershoot, provide a window into the dynamic relationships of the underlying physiological var...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.07.034

    authors： Havlicek M,Ivanov D,Poser BA,Uludag K

    更新日期：2017-10-01 00:00:00

  • Visualizing oxidative stress-induced depression of cardiac vagal baroreflex by MRI/DTI in a mouse neurogenic hypertension model.

    abstract：:A clinical hallmark of hypertension is impairment of the cardiac vagal baroreflex, which maintains stable blood pressure and heart rate under physiological conditions. There is also evidence that oxidative stress in the brain is associated with neurogenic hypertension. We tested the hypothesis that an augmented supero...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2013.05.124

    authors： Tsai CY,Su CH,Baudrie V,Laude D,Weng JC,Chang AY,Chan JY,Elghozi JL,Chan SH

    更新日期：2013-11-15 00:00:00

  • Auditory cortical delta-entrainment interacts with oscillatory power in multiple fronto-parietal networks.

    abstract：:The timing of slow auditory cortical activity aligns to the rhythmic fluctuations in speech. This entrainment is considered to be a marker of the prosodic and syllabic encoding of speech, and has been shown to correlate with intelligibility. Yet, whether and how auditory cortical entrainment is influenced by the activ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2016.11.062

    authors： Keitel A,Ince RAA,Gross J,Kayser C

    更新日期：2017-02-15 00:00:00

  • A multivariate analysis of neuroanatomic relationships in a genetically informative pediatric sample.

    abstract：:An important component of brain mapping is an understanding of the relationships between neuroanatomic structures, as well as the nature of shared causal factors. Prior twin studies have demonstrated that much of individual differences in human anatomy are caused by genetic differences, but information is limited on w...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.04.232

    authors： Schmitt JE,Wallace GL,Rosenthal MA,Molloy EA,Ordaz S,Lenroot R,Clasen LS,Blumenthal JD,Kendler KS,Neale MC,Giedd JN

    更新日期：2007-03-01 00:00:00

  • Task-dependent modulation of the visual sensory thalamus assists visual-speech recognition.

    abstract：:The cerebral cortex modulates early sensory processing via feed-back connections to sensory pathway nuclei. The functions of this top-down modulation for human behavior are poorly understood. Here, we show that top-down modulation of the visual sensory thalamus (the lateral geniculate body, LGN) is involved in visual-...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.05.032

    authors： Díaz B,Blank H,von Kriegstein K

    更新日期：2018-09-01 00:00:00

  • Single-trial reconstruction of finger-pinch forces from human motor-cortical activation measured by near-infrared spectroscopy (NIRS).

    abstract：:Near-infrared spectroscopy (NIRS) has recently been used to measure human motor-cortical activation, enabling the classification of the content of a sensory-motor event such as whether the left or right hand was used. Here, we advance this NIRS application by demonstrating quantitative estimates of multiple sensory-mo...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.04.050

    authors： Nambu I,Osu R,Sato MA,Ando S,Kawato M,Naito E

    更新日期：2009-08-15 00:00:00

  • Reducing the unwanted draining vein BOLD contribution in fMRI with statistical post-processing methods.

    abstract：:Recent BOLD fMRI data analysis methods show promise in reducing contributions from draining veins. The phase regressor method developed by [Menon, R.S., 2002. Post-acquisition suppression of large-vessel BOLD signals in high-resolution fMRI. Magn. Reson. Med., 47, 1-9] creates phase and magnitude images, regresses mag...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.03.075

    authors： Nencka AS,Rowe DB

    更新日期：2007-08-01 00:00:00

  • Cognitive processing speed and the structure of white matter pathways: convergent evidence from normal variation and lesion studies.

    abstract：:We investigated the relation between cognitive processing speed and structural properties of white matter pathways via convergent imaging studies in healthy and brain-injured groups. Voxel-based morphometry (VBM) was applied to diffusion tensor imaging data from thirty-nine young healthy subjects in order to investiga...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2008.03.057

    authors： Turken A,Whitfield-Gabrieli S,Bammer R,Baldo JV,Dronkers NF,Gabrieli JD

    更新日期：2008-08-15 00:00:00

  • Multivariate combination of magnetization transfer, T2* and B0 orientation to study the myelo-architecture of the in vivo human cortex.

    abstract：:Recently, T2* imaging at 7Tesla (T) MRI was shown to reveal microstructural features of the cortical myeloarchitecture thanks to an increase in contrast-to-noise ratio. However, several confounds hamper the specificity of T2* measures (iron content, blood vessels, tissues orientation). Another metric, magnetization tr...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.06.033

    authors： Mangeat G,Govindarajan ST,Mainero C,Cohen-Adad J

    更新日期：2015-10-01 00:00:00

  • Brain activation patterns during visual episodic memory processing among first-degree relatives of schizophrenia subjects.

    abstract：:Episodic memory deficits are proposed as a potential intermediate phenotype of schizophrenia. We examined deficits in visual episodic memory and associated brain activation differences among early course schizophrenia (n=22), first-degree relatives (n=16) and healthy controls without personal or family history of psyc...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2012.08.030

    authors： Stolz E,Pancholi KM,Goradia DD,Paul S,Keshavan MS,Nimgaonkar VL,Prasad KM

    更新日期：2012-11-15 00:00:00

  • Neural circuitry underlying sentence-level linguistic prosody.

    abstract：:This study investigates the neural substrates underlying the perception of two sentence-level prosodic phenomena in Mandarin Chinese: contrastive stress (initial vs. final emphasis position) and intonation (declarative vs. interrogative modality). In an fMRI experiment, Chinese and English listeners were asked to sele...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.neuroimage.2005.06.002

    authors： Tong Y,Gandour J,Talavage T,Wong D,Dzemidzic M,Xu Y,Li X,Lowe M

    更新日期：2005-11-01 00:00:00