Abstract：
:An important component of brain mapping is an understanding of the relationships between neuroanatomic structures, as well as the nature of shared causal factors. Prior twin studies have demonstrated that much of individual differences in human anatomy are caused by genetic differences, but information is limited on whether different structures share common genetic factors. We performed a multivariate statistical genetic analysis on volumetric MRI measures (cerebrum, cerebellum, lateral ventricles, corpus callosum, thalamus, and basal ganglia) from a pediatric sample of 326 twins and 158 singletons. Our results suggest that the great majority of variability in cerebrum, cerebellum, thalamus and basal ganglia is determined by a single genetic factor. Though most (75%) of the variability in corpus callosum was explained by additive genetic effects these were largely independent of other structures. We also observed relatively small but significant environmental effects common to multiple neuroanatomic regions, particularly between thalamus, basal ganglia, and lateral ventricles. These findings are concordant with prior volumetric twin studies and support radial models of brain evolution.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Schmitt JE,Wallace GL,Rosenthal MA,Molloy EA,Ordaz S,Lenroot R,Clasen LS,Blumenthal JD,Kendler KS,Neale MC,Giedd JNdoi
10.1016/j.neuroimage.2006.04.232subject
Has Abstractpub_date
2007-03-01 00:00:00pages
70-82issue
1eissn
1053-8119issn
1095-9572pii
S1053-8119(06)00500-3journal_volume
35pub_type
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