Abstract：
:A series of reports have recently appeared using tensor based morphometry statistically-defined regions of interest, Stat-ROIs, to quantify longitudinal atrophy in structural MRIs from the Alzheimer's Disease Neuroimaging Initiative (ADNI). This commentary focuses on one of these reports, Hua et al. (2010), but the issues raised here are relevant to the others as well. Specifically, we point out a temporal pattern of atrophy in subjects with Alzheimer's disease and mild cognitive impairment whereby the majority of atrophy in two years occurs within the first 6 months, resulting in overall elevated estimated rates of change. Using publicly-available ADNI data, this temporal pattern is also found in a group of identically-processed healthy controls, strongly suggesting that methodological bias is corrupting the measures. The resulting bias seriously impacts the validity of conclusions reached using these measures; for example, sample size estimates reported by Hua et al. (2010) may be underestimated by a factor of five to sixteen.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Thompson WK,Holland D,Alzheimer's Disease Neuroimaging Initiative.doi
10.1016/j.neuroimage.2010.11.092subject
Has Abstractpub_date
2011-07-01 00:00:00pages
1-4issue
1eissn
1053-8119issn
1095-9572pii
S1053-8119(11)00149-2journal_volume
57pub_type
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