Abstract:
:In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) - a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In some of the largest neuroimaging studies to date - of schizophrenia and major depression - ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects. In partnership with other consortia including ADNI, CHARGE, IMAGEN and others1, ENIGMA's genomic screens - now numbering over 30,000 MRI scans - have revealed at least 8 genetic loci that affect brain volumes. Downstream of gene findings, ENIGMA has revealed how these individual variants - and genetic variants in general - may affect both the brain and risk for a range of diseases. The ENIGMA consortium is discovering factors that consistently affect brain structure and function that will serve as future predictors linking individual brain scans and genomic data. It is generating vast pools of normative data on brain measures - from tens of thousands of people - that may help detect deviations from normal development or aging in specific groups of subjects. We discuss challenges and opportunities in applying these predictors to individual subjects and new cohorts, as well as lessons we have learned in ENIGMA's efforts so far.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Thompson PM,Andreassen OA,Arias-Vasquez A,Bearden CE,Boedhoe PS,Brouwer RM,Buckner RL,Buitelaar JK,Bulayeva KB,Cannon DM,Cohen RA,Conrod PJ,Dale AM,Deary IJ,Dennis EL,de Reus MA,Desrivieres S,Dima D,Donohoe G,Fisherdoi
10.1016/j.neuroimage.2015.11.057subject
Has Abstractpub_date
2017-01-15 00:00:00pages
389-408issue
Pt Beissn
1053-8119issn
1095-9572pii
S1053-8119(15)01081-2journal_volume
145pub_type
杂志文章,评审相关文献
NEUROIMAGE文献大全abstract::To investigate cortical auditory and motor coupling in professional musicians, we compared the functional magnetic resonance imaging (fMRI) activity of seven pianists to seven non-musicians utilizing a passive task paradigm established in a previous learning study. The tasks involved either passively listening to shor...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2005.10.044
更新日期:2006-04-15 00:00:00
abstract::Motor tasks involve neural activity in a spatially distributed network. It is assumed that coherent activity between these brain structures reflects functional connectivity. The aim of the present study was to investigate brain areas associated with a unimanual auditorily paced finger-tapping task and to characterize ...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroimage.2004.10.009
更新日期:2005-02-01 00:00:00
abstract::Establishing baseline MRI biomarkers for normal brain aging is significant and valuable for separating normal changes in the brain structure and function from different neurological diseases. In this paper for the first time we have simultaneously measured a variety of tissue specific contributions defining R2* relaxa...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.03.022
更新日期:2016-06-01 00:00:00
abstract::Functional connectivity is derived from inter-regional correlations in spontaneous fluctuations of brain activity, and can be represented in terms of complete graphs with continuous (real-valued) edges. The structure of functional connectivity networks is strongly affected by signal processing procedures to remove the...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.116603
更新日期:2020-05-01 00:00:00
abstract::Analyses of spontaneous hemodynamic fluctuations observed on functional magnetic resonance imaging (fMRI) have revealed the existence of temporal correlations in signal changes between widely separated brain regions during the resting state, termed "resting state functional connectivity." Recent studies have demonstra...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.12.075
更新日期:2011-05-01 00:00:00
abstract::Brain asymmetry is a phenomenon well known for handedness and language specialization and has also been studied in motor cortex. Less is known about hemispheric asymmetries in the somatosensory cortex. In the present study, we systematically investigated the representation of somatosensory function analyzing early sub...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/s1053-8119(03)00164-2
更新日期:2003-07-01 00:00:00
abstract::Multi-echo T(2) relaxation decay data was acquired for 5 preadolescent males (age range 9-12 years). A signal to noise filter appropriate for multi-exponential T(2) analysis was then applied to remove voxels which did not accurately fit the modelled curve. The remaining voxels were designated "highly myelinated" if th...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.07.038
更新日期:2008-12-01 00:00:00
abstract::An amazingly wide range of complex behavior emerges from the cerebral cortex. Much of the information processing that leads to these behaviors is performed in neocortical circuits that span throughout the six layers of the cortex. Maintaining this circuit activity requires substantial quantities of oxygen and energy s...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2017.06.046
更新日期:2019-08-15 00:00:00
abstract::In any non-deterministic environment, unexpected events can indicate true changes in the world (and require behavioural adaptation) or reflect chance occurrence (and must be discounted). Adaptive behaviour requires distinguishing these possibilities. We investigated how humans achieve this by integrating high-level in...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2016.08.057
更新日期:2017-02-01 00:00:00
abstract::In 2001, we published a paper on the representation of faces and objects in ventral temporal cortex that introduced a new method for fMRI analysis, which subsequently came to be called multivariate pattern analysis (MVPA). MVPA now refers to a diverse set of methods that analyze neural responses as patterns of activit...
journal_title:NeuroImage
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neuroimage.2012.03.016
更新日期:2012-08-15 00:00:00
abstract::Recent BOLD fMRI data analysis methods show promise in reducing contributions from draining veins. The phase regressor method developed by [Menon, R.S., 2002. Post-acquisition suppression of large-vessel BOLD signals in high-resolution fMRI. Magn. Reson. Med., 47, 1-9] creates phase and magnitude images, regresses mag...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.03.075
更新日期:2007-08-01 00:00:00
abstract::(R)-[11C]PK11195 has been used for quantifying cerebral microglial activation in vivo. In previous studies, both plasma input and reference tissue methods have been used, usually in combination with a region of interest (ROI) approach. Definition of ROIs, however, can be labourious and prone to interobserver variation...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.02.013
更新日期:2007-05-01 00:00:00
abstract::We present an experimental evaluation of a new algorithm for the detection of activated areas in brain functional maps. The new algorithm, named HMSD, is based on a hierarchical multiscale description of the difference image in terms of connected objects. Size and magnitude of each object are simultaneously tested wit...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.1995.1033
更新日期:1995-12-01 00:00:00
abstract::We studied 13 healthy subjects with a multichannel magnetoencephalography (MEG) system to investigate the somatotopic representation of the ear in the primary somatosensory cortex (SI). We stimulated three parts of the left ear: the helix, the lobulus, and the tragus. The somatosensory-evoked magnetic fields (SEFs) we...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2000.0695
更新日期:2001-02-01 00:00:00
abstract::Event-related potentials (ERPs) were used to trace changes in brain activity related to progress in second language learning. Twelve English-speaking exchange students learning German in Switzerland were recruited. ERPs to visually presented single words from the subjects' native language (English), second language (G...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.07.008
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:High sensation-seekers (HSS) pursue novelty even at the cost of self-harm. When challenged, HSS are less anxious, show blunted physiological (cortisol, startle) and neurobiological (prefrontal-limbic) responses, and devalue aversive outcomes. Here, we investigate how these features interact under conditions ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.08.038
更新日期:2014-12-01 00:00:00
abstract:INTRODUCTION:We assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study. METHOD:Meta-analysis: We conducted a systematic search for articles published between 1983 and 2003 that reported P300 measures in non-psychotic rel...
journal_title:NeuroImage
pub_type: 杂志文章,meta分析
doi:10.1016/j.neuroimage.2005.05.022
更新日期:2005-10-01 00:00:00
abstract::In this work we treat fMRI data analysis as a spatiotemporal system identification problem and address issues of model formulation, estimation, and model comparison. We present a new model that includes a physiologically based hemodynamic response and an empirically derived low-frequency noise model. We introduce an e...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2001.0870
更新日期:2001-10-01 00:00:00
abstract::Axon diameter mapping using high-gradient diffusion MRI has generated great interest as a noninvasive tool for studying trends in axonal size in the human brain. One of the main barriers to mapping axon diameter across the whole brain is accounting for complex white matter fiber configurations (e.g., crossings and fan...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117197
更新日期:2020-11-15 00:00:00
abstract::Within the framework of statistical mapping, there are up to now only two tests used to assess the regional significance in functional images. One is based on the magnitude of the foci and tends to detect high intensity signals, while the second is based on the spatial extent of regions defined by a simple thresholdin...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.1996.0248
更新日期:1997-02-01 00:00:00
abstract::Schippers, Renken and Keysers (NeuroImage, 2011) present a simulation of multi-subject lag-based causality estimation. We fully agree that single-subject evaluations (e.g., Smith et al., 2011) need to be revisited in the context of multi-subject studies, and Schippers' paper is a good example, including detailed multi...
journal_title:NeuroImage
pub_type: 评论,杂志文章
doi:10.1016/j.neuroimage.2011.08.015
更新日期:2012-01-16 00:00:00
abstract::We have prepared an atlas of the human cerebellum using high-resolution magnetic resonance-derived images warped into the proportional stereotaxic space of Talairach and Tournoux. Software that permits simultaneous visualization of the three cardinal planes facilitated the identification of the cerebellar fissures and...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.1999.0459
更新日期:1999-09-01 00:00:00
abstract::Automated measures of cerebral magnetic resonance images (MRI) often provide greater speed and reliability compared to manual techniques but can be particularly sensitive to motion artifact. This study employed an automatic MRI analysis program that quantified regional gray matter volume and created images for verific...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1006/nimg.2002.1076
更新日期:2002-05-01 00:00:00
abstract::Chiari II-malformation is a complex congenital deformity of the brain which is frequently associated with hydrocephalus. Abnormalities of the corpus callosum are known to occur in the majority of patients. The objective of the present study was to study the microstructure of the corpus callosum (CC) and the anterior c...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.09.006
更新日期:2009-01-15 00:00:00
abstract::With this study, we explored the blood oxygen level-dependent responses within the temporal lobe to short auditory stimuli of different classes. To address this issue, we performed an attentive listening event-related fMRI study, where subjects were required to concentrate during the presentation of different types of...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2003.07.034
更新日期:2003-12-01 00:00:00
abstract::Individuals at clinical high-risk (CHR) for psychosis are characterized by attenuated psychotic symptoms. Only a minority of CHR individuals convert to full-blown psychosis. Therefore, there is a strong interest in identifying neurobiological abnormalities underlying the psychosis risk syndrome. Dynamic functional con...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.10.022
更新日期:2018-10-15 00:00:00
abstract::Although it is known that responses in the auditory cortex are evoked predominantly contralateral to the side of stimulation, the lateralization of responses at lower levels in the human central auditory system has hardly been studied. Furthermore, little is known on the functional interactions between the involved pr...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2005.06.024
更新日期:2005-11-01 00:00:00
abstract::Certain groups (e.g., women, older adults, and the economically disadvantaged) are universally stigmatized. Numerous studies, however, have identified cross-cultural differences in the attitudes expressed toward stigmatized groups. These differences may potentially be due to existing cross-cultural dissimilarities in ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.08.030
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Our primary objective was to compare the performance of unaccelerated vs. accelerated structural MRI for measuring disease progression using serial scans in Alzheimer's disease (AD). METHODS:We identified cognitively normal (CN), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI) a...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.03.026
更新日期:2015-06-01 00:00:00
abstract::Spatiotemporal filtering and amplification of sensory information at multiple levels during the generation of perceptual representations is a fundamental processing principle of the nervous system. While for the visual and auditory system temporal filtering of sensory signals has been noticed for a long time, respecti...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.09.003
更新日期:2018-12-01 00:00:00