Abstract:
:Within the framework of statistical mapping, there are up to now only two tests used to assess the regional significance in functional images. One is based on the magnitude of the foci and tends to detect high intensity signals, while the second is based on the spatial extent of regions defined by a simple thresholding of the statistical map, a test that is more sensitive to extended signals. The aim of this paper is to combine the two tests into a single test that is more sensitive to a wider range of signals. This combined test is based on an analytical approximation of the distribution of these two parameters (size and height) and is applied in the context of statistical maps. The risk of error in noise-only 2D or 3D volumes is assessed under a wide range of experimental conditions obtained by varying both the resolution of the map and the threshold at which clusters are defined. In addition, we have investigated this new test on simulated signals, and applied it to an experimental PET dataset. The experimental risk of error is close to the predicted one, and the overall sensitivity increases when analyzing a volume containing different types of signals.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Poline JB,Worsley KJ,Evans AC,Friston KJdoi
10.1006/nimg.1996.0248subject
Has Abstractpub_date
1997-02-01 00:00:00pages
83-96issue
2eissn
1053-8119issn
1095-9572pii
S1053-8119(96)90248-7journal_volume
5pub_type
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