当前位置： SCI文献检索 > NEUROIMAGE期刊下所有文献 > Dopaminergic dysfunction in attention deficit hyperactivity disorder (ADHD), differences between pharmacologically treated and never treated young adults: a 3,4-dihdroxy-6-[18F]fluorophenyl-l-alanine PET study.

Dopaminergic dysfunction in attention deficit hyperactivity disorder (ADHD), differences between pharmacologically treated and never treated young adults: a 3,4-dihdroxy-6-[18F]fluorophenyl-l-alanine PET study.

Abstract：

:The dopaminergic system plays a key role in attention-deficit/hyperactivity disorder (ADHD). Methylphenidate (MP), a dopamine (DA) reuptake inhibitor, is a drug of first choice for treating ADHD. This cross-over study investigated alterations in DA metabolism in young males with ADHD who had never been pharmacologically treated and MP-treated patients in comparison to healthy subjects. Dynamic 3,4-dihdroxy-6-[18F]fluorophenyl-L-alanine (FDOPA) PET scans were carried out on 20 male patients with ADHD and 18 healthy men. Eight ADHD patients had never been treated with psychostimulants, the rest had received MP. Based on the tissue-slope-intercept plot parametric images of FDOPA influx rate constant (Ki) were generated for each subject from dynamic 3D FDOPA datasets and transformed into standard stereotactic space. First a volume of interest analysis was performed on each single subject. In a second step data were introduced to a SPM2 analysis to detect significant changes in mean voxel Ki values between the normal control group and each patient group. In comparison to controls, ADHD patients as a group (irrespective of treatment status) showed a lower Ki in bilateral putamen, amygdala and dorsal midbrain. There was a lower Ki in the left putamen, right amygdala and right dorsal midbrain in untreated patients compared to controls together with a relative higher influx in the left amygdala and right anterior cingulate cortex. In contrast, methylphenidate treatment was associated with a significantly lower Ki in the striatum and amygdala bilaterally, and in the right dorsal midbrain. Untreated young adult ADHD patients showed a dopamine dysfunction that might be partly due to compensatory mechanisms. MP seems to down-regulate dopamine turnover. This effect might be one component in the mechanism of action of this drug in ADHD treatment.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Ludolph AG,Kassubek J,Schmeck K,Glaser C,Wunderlich A,Buck AK,Reske SN,Fegert JM,Mottaghy FM

doi

10.1016/j.neuroimage.2008.02.025

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

718-27

issue

3

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(08)00169-9

journal_volume

41

pub_type

杂志文章

相关文献

NEUROIMAGE文献大全
  • Neural correlates of high and craving during cocaine self-administration using BOLD fMRI.

    abstract：:Modern theories of drug dependence hold the hedonic effects of drug-taking central to understanding the motivation for compulsive drug use. Previous neuroimaging studies have begun to identify brain regions associated with acute drug effects after passive delivery. In this study, a more naturalistic model of cocaine s...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.neuroimage.2005.03.030

    authors： Risinger RC,Salmeron BJ,Ross TJ,Amen SL,Sanfilipo M,Hoffmann RG,Bloom AS,Garavan H,Stein EA

    更新日期：2005-07-15 00:00:00

  • Probabilistic 3D MRI atlas of the human cerebellar dentate/interposed nuclei.

    abstract：:In a previous study, a three-dimensional (3D) MRI atlas of the human cerebellar nuclei was introduced based on findings in one healthy human subject [Dimitrova, A., Weber, J., Redies, C., Kindsvater, K., Maschke, M., Kolb, F.P., Forsting, M., Diener, H.C., Timmann, D., 2002. MRI atlas of the human cerebellar nuclei. N...

    journal_title：NeuroImage

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuroimage.2005.09.020

    authors： Dimitrova A,Zeljko D,Schwarze F,Maschke M,Gerwig M,Frings M,Beck A,Aurich V,Forsting M,Timmann D

    更新日期：2006-03-01 00:00:00

  • Task-induced deactivation and the "resting" state.

    abstract：:Task-induced decreases in blood flow and the widespread use of "resting" baselines produced unexpected and discrepant results in early cognitive imaging studies, especially in language comprehension experiments. Here I describe from a personal perspective some of the events and thought processes leading to the first h...

    journal_title：NeuroImage

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.neuroimage.2011.09.026

    authors： Binder JR

    更新日期：2012-08-15 00:00:00

  • Parietal cortex tracks the amount of information retrieved even when it is not the basis of a memory decision.

    abstract：:Although the parietal cortex is not conventionally associated with memory, a large number of recent fMRI studies have suggested that that the parietal cortex may play a role in recognition memory. Activity in the lateral parietal cortex is correlated with the subjective impression that an item is old. It has therefore...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.11.066

    authors： Guerin SA,Miller MB

    更新日期：2011-03-15 00:00:00

  • Neural correlates of memory retrieval during recognition memory and cued recall.

    abstract：:Regional brain activity, measured by H215O PET, was investigated during recognition memory and word-stem cued recall of words in order to compare the neural correlates of two components of memory retrieval-effort and success-as a function of task. For each task there was a baseline and two retrieval conditions. In one...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1006/nimg.1998.0363

    authors： Rugg MD,Fletcher PC,Allan K,Frith CD,Frackowiak RS,Dolan RJ

    更新日期：1998-10-01 00:00:00

  • Can high-field MREIT be used to directly detect neural activity? Theoretical considerations.

    abstract：:We sought to determine the feasibility of directly studying neural tissue activity by analysis of differential phase shifts in MRI signals that occurred when trickle currents were applied to a bath containing active or resting neural tissue. We developed a finite element bidomain model of an aplysia abdominal ganglion...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.04.005

    authors： Sadleir RJ,Grant SC,Woo EJ

    更新日期：2010-08-01 00:00:00

  • Cortical functional connectivity indexes arousal state during sleep and anesthesia.

    abstract：:Disruption of cortical connectivity likely contributes to loss of consciousness (LOC) during both sleep and general anesthesia, but the degree of overlap in the underlying mechanisms is unclear. Both sleep and anesthesia comprise states of varying levels of arousal and consciousness, including states of largely mainta...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2020.116627

    authors： Banks MI,Krause BM,Endemann CM,Campbell DI,Kovach CK,Dyken ME,Kawasaki H,Nourski KV

    更新日期：2020-05-01 00:00:00

  • Electromagnetic responses to invisible face stimuli during binocular suppression.

    abstract：:When two incompatible monocular images compete for perceptual dominance, one can dominate awareness while the other is suppressed and invisible. It has been suggested that binocular suppression of this kind involves competitive neuronal interactions at multiple levels of the visual processing hierarchy. Here we asked ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.02.046

    authors： Sterzer P,Jalkanen L,Rees G

    更新日期：2009-07-01 00:00:00

  • Cortical activation to auditory mismatch elicited by frequency deviant and complex novel sounds: a PET study.

    abstract：:The analysis of auditory deviant events outside the focus of attention is a fundamental capacity of human information processing and has been studied in experiments on Mismatch Negativity (MMN) and the P3a component in evoked potential research. However, generators contributing to these components are still under disc...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章

    doi：10.1006/nimg.2002.1176

    authors： Müller BW,Jüptner M,Jentzen W,Müller SP

    更新日期：2002-09-01 00:00:00

  • Brain extraction on MRI scans in presence of diffuse glioma: Multi-institutional performance evaluation of deep learning methods and robust modality-agnostic training.

    abstract：:Brain extraction, or skull-stripping, is an essential pre-processing step in neuro-imaging that has a direct impact on the quality of all subsequent processing and analyses steps. It is also a key requirement in multi-institutional collaborations to comply with privacy-preserving regulations. Existing automated method...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2020.117081

    authors： Thakur S,Doshi J,Pati S,Rathore S,Sako C,Bilello M,Ha SM,Shukla G,Flanders A,Kotrotsou A,Milchenko M,Liem S,Alexander GS,Lombardo J,Palmer JD,LaMontagne P,Nazeri A,Talbar S,Kulkarni U,Marcus D,Colen R,Davatzikos

    更新日期：2020-10-15 00:00:00

  • fMRI-guided white matter connectivity in fluid and crystallized cognitive abilities in healthy adults.

    abstract：:This study examined within-subject differences among three fluid abilities that decline with age: reasoning, episodic memory and processing speed, compared with vocabulary, a crystallized ability that is maintained with age. The data were obtained from the Reference Ability Neural Network (RANN) study from which 221 p...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2020.116809

    authors： Gazes Y,Lee S,Sakhardande J,Mensing A,Razlighi Q,Ohkawa A,Pleshkevich M,Luo L,Habeck C

    更新日期：2020-07-15 00:00:00

  • Conflict monitoring mechanism at the single-neuron level in the human ventral anterior cingulate cortex.

    abstract：:Life requires monitoring and adjusting behavior in the face of conflicts. The conflict monitoring theory implicates the anterior cingulate cortex (ACC) in these processes; its ventral aspect (vACC) specializes in emotional conflict. To elucidate the underpinning neural mechanism, we recorded vACC extracellular activit...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.03.028

    authors： Shapira-Lichter I,Strauss I,Oren N,Gazit T,Sammartino F,Giacobbe P,Kennedy S,Hutchison WD,Fried I,Hendler T,Lozano AM

    更新日期：2018-07-15 00:00:00

  • More workload on the central executive of working memory, less attention capture by novel visual distractors: evidence from an fMRI study.

    abstract：:The present study examined the interaction of the central executive in working memory with visual attention. Native Chinese participants were given two versions of a number subtraction task, one of low demand and one of high demand, and were asked to ignore a simultaneously presented peripheral distractor. The distrac...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.neuroimage.2004.06.025

    authors： Spinks JA,Zhang JX,Fox PT,Gao JH,Hai Tan L

    更新日期：2004-10-01 00:00:00

  • Escaping the here and now: evidence for a role of the default mode network in perceptually decoupled thought.

    abstract：:Cognition that is not based on perception can lead to at least two different outcomes. In some situations, cognition that is independent of perception can allow actions to be selected other than those prescribed by immediate perceptual input. In others, cognition can be independent of perception and unrelated to the c...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2012.12.012

    authors： Smallwood J,Tipper C,Brown K,Baird B,Engen H,Michaels JR,Grafton S,Schooler JW

    更新日期：2013-04-01 00:00:00

  • Quantifying development: Investigating highly myelinated voxels in preadolescent corpus callosum.

    abstract：:Multi-echo T(2) relaxation decay data was acquired for 5 preadolescent males (age range 9-12 years). A signal to noise filter appropriate for multi-exponential T(2) analysis was then applied to remove voxels which did not accurately fit the modelled curve. The remaining voxels were designated "highly myelinated" if th...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2008.07.038

    authors： Whitaker KJ,Kolind SH,MacKay AL,Clark CM

    更新日期：2008-12-01 00:00:00

  • Increased DAT binding in the early stage of the dopaminergic lesion: a longitudinal [11C]PE2I binding study in the MPTP-monkey.

    abstract：:The delayed appearance of motor symptoms in PD poses a crucial challenge for early detection of the disease. We measured the binding potential of the selective dopamine active transporter (DAT) radiotracer [(11)C]PE2I in MPTP-treated macaque monkeys, thus establishing a detailed profile of the nigrostriatal DA status ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2014.07.059

    authors： Vezoli J,Dzahini K,Costes N,Wilson CR,Fifel K,Cooper HM,Kennedy H,Procyk E

    更新日期：2014-11-15 00:00:00

  • Dynamic subcortical blood flow during male sexual activity with ecological validity: a perfusion fMRI study.

    abstract：:This study used arterial spin labeling (ASL) fMRI to measure brain perfusion in a group of healthy men under conditions that closely resembled customary sexual behavior. Serial perfusion measures for 30 min during two self-limited periods of partnered penis stimulation, and during post-stimulatory periods, revealed no...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.12.034

    authors： Georgiadis JR,Farrell MJ,Boessen R,Denton DA,Gavrilescu M,Kortekaas R,Renken RJ,Hoogduin JM,Egan GF

    更新日期：2010-03-01 00:00:00

  • Where syntax meets math: right intraparietal sulcus activation in response to grammatical number agreement violations.

    abstract：:Previous research has shown that the processing of words referring to actions activated motor areas. Here, we show activation of the right intraparietal sulcus, an area that has been associated with quantity processing, when participants are asked to read pairs of words with number agreement violations as opposed to p...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.09.058

    authors： Carreiras M,Carr L,Barber HA,Hernandez A

    更新日期：2010-01-15 00:00:00

  • The roles of superficial amygdala and auditory cortex in music-evoked fear and joy.

    abstract：:This study investigates neural correlates of music-evoked fear and joy with fMRI. Studies on neural correlates of music-evoked fear are scant, and there are only a few studies on neural correlates of joy in general. Eighteen individuals listened to excerpts of fear-evoking, joy-evoking, as well as neutral music and ra...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2013.05.008

    authors： Koelsch S,Skouras S,Fritz T,Herrera P,Bonhage C,Küssner MB,Jacobs AM

    更新日期：2013-11-01 00:00:00

  • Diffusion tensor MRI of axonal plasticity in the rat hippocampus.

    abstract：:The aim of this study was to explore non-invasive imaging methods to detect post-injury structural axonal plasticity. Brain injury was launched by status epilepticus induced by intraperitoneal injection of either kainic acid or pilocarpine. Several months later, ex vivo diffusion tensor magnetic resonance imaging (DTI...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.02.077

    authors： Laitinen T,Sierra A,Pitkänen A,Gröhn O

    更新日期：2010-06-01 00:00:00

  • Task-driven ICA feature generation for accurate and interpretable prediction using fMRI.

    abstract：:Functional Magnetic Resonance Imaging (fMRI) shows significant potential as a tool for predicting clinically important information such as future disease progression or drug effect from brain activity. Multivariate techniques have been developed that combine fMRI signals from across the brain to produce more robust pr...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.12.053

    authors： Duff EP,Trachtenberg AJ,Mackay CE,Howard MA,Wilson F,Smith SM,Woolrich MW

    更新日期：2012-03-01 00:00:00

  • Paired pulse depression in the somatosensory cortex: associations between MEG and BOLD fMRI.

    abstract：:Interpretation of the blood oxygen level dependent (BOLD) response measured using functional magnetic resonance imaging (fMRI) requires an understanding of the underlying neuronal activity. Here we report on a study using both magnetoencephalography (MEG) and BOLD fMRI, to measure the brain's functional response to el...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.10.037

    authors： Stevenson CM,Wang F,Brookes MJ,Zumer JM,Francis ST,Morris PG

    更新日期：2012-02-01 00:00:00

  • Predicting response originality through brain activity: An analysis of changes in EEG alpha power during the generation of alternative ideas.

    abstract：:Growing neurophysiological evidence points to a role of alpha oscillations in divergent thinking (DT). In particular, studies have shown a consistent EEG alpha synchronization during performance on the Alternative Uses Task (AUT), a well-established DT task. However, there is a need for investigating the brain dynamic...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2019.116385

    authors： Agnoli S,Zanon M,Mastria S,Avenanti A,Corazza GE

    更新日期：2020-02-15 00:00:00

  • The construction of a Chinese MRI brain atlas: a morphometric comparison study between Chinese and Caucasian cohorts.

    abstract：:We developed a novel brain atlas template to facilitate computational brain studies of Chinese subjects and populations using high quality magnetic resonance imaging (MRI) and well-validated image analysis techniques. To explore the ethnicity-based structural brain differences, we used the MRI scans of 35 Chinese male...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.01.111

    authors： Tang Y,Hojatkashani C,Dinov ID,Sun B,Fan L,Lin X,Qi H,Hua X,Liu S,Toga AW

    更新日期：2010-05-15 00:00:00

  • Dynamic causal modeling for calcium imaging: Exploration of differential effective connectivity for sensory processing in a barrel cortical column.

    abstract：:Multi-photon calcium imaging (CaI) is an important tool to assess activities of neural populations within a column in the sensory cortex. However, the complex asymmetrical interactions among neural populations, termed effective connectivity, cannot be directly assessed by measuring the activity of each neuron or neura...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2019.116008

    authors： Jung K,Kang J,Chung S,Park HJ

    更新日期：2019-11-01 00:00:00

  • Investigating the non-linearity of the BOLD cerebrovascular reactivity response to targeted hypo/hypercapnia at 7T.

    abstract：:Cerebrovascular reactivity (CVR) is a mechanism responsible for maintaining stable perfusion pressure within the brain via smooth muscle mediated modulations of vascular tone. The amplitude of cerebral blood flow (CBF) change in response to a stimulus has been evaluated using Blood Oxygen Level Dependent (BOLD) MRI, h...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2014.05.006

    authors： Bhogal AA,Siero JC,Fisher JA,Froeling M,Luijten P,Philippens M,Hoogduin H

    更新日期：2014-09-01 00:00:00

  • Bayesian Optimisation of Large-Scale Biophysical Networks.

    abstract：:The relationship between structure and function in the human brain is well established, but not yet well characterised. Large-scale biophysical models allow us to investigate this relationship, by leveraging structural information (e.g. derived from diffusion tractography) in order to couple dynamical models of local ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.02.063

    authors： Hadida J,Sotiropoulos SN,Abeysuriya RG,Woolrich MW,Jbabdi S

    更新日期：2018-07-01 00:00:00

  • The advantage of combining MEG and EEG: comparison to fMRI in focally stimulated visual cortex.

    abstract：:To exploit the high (millisecond) temporal resolution of magnetoencephalography (MEG) and electroencephalography (EEG) for measuring neuronal dynamics within well-defined brain regions, it is important to quantitatively assess their localizing ability. Previous modeling studies and empirical data suggest that a combin...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.03.066

    authors： Sharon D,Hämäläinen MS,Tootell RB,Halgren E,Belliveau JW

    更新日期：2007-07-15 00:00:00

  • Electrophysiological correlates of remembering emotional pictures.

    abstract：:Extensive evidence shows that emotional events tend to be remembered in greater detail and with an enhanced sense of vividness compared to neutral events. The current study investigated the neural correlates of this phenomenon during retrieval using the event-related potentials technique (ERP). Participants were asked...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.07.030

    authors： Schaefer A,Pottage CL,Rickart AJ

    更新日期：2011-01-01 00:00:00

  • Functional brain network organisation of children between 2 and 5 years derived from reconstructed activity of cortical sources of high-density EEG recordings.

    abstract：:There is increasing interest in applying connectivity analysis to brain measures (Rubinov and Sporns, 2010), but most studies have relied on fMRI, which substantially limits the participant groups and numbers that can be studied. High-density EEG recordings offer a comparatively inexpensive easy-to-use alternative, bu...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2013.06.003

    authors： Bathelt J,O'Reilly H,Clayden JD,Cross JH,de Haan M

    更新日期：2013-11-15 00:00:00