Abstract：
:Modern theories of drug dependence hold the hedonic effects of drug-taking central to understanding the motivation for compulsive drug use. Previous neuroimaging studies have begun to identify brain regions associated with acute drug effects after passive delivery. In this study, a more naturalistic model of cocaine self-administration (SA) was employed in order to identify those sites associated with drug-induced high and craving as measures of reward and motivation. Non-treatment seeking cocaine-dependent subjects chose both when and how often i.v. cocaine administration occurred within a medically supervised SA procedure. Both functional magnetic resonance imaging (fMRI) data and real-time behavioral ratings were acquired during the 1-h SA period. Drug-induced HIGH was found to correlate negatively with activity in limbic, paralimbic, and mesocortical regions including the nucleus accumbens (NAc), inferior frontal/orbitofrontal gyrus (OFC), and anterior cingulate (AC), while CRAVING correlated positively with activity in these regions. This study provides the first evidence in humans that changes in subjective state surrounding cocaine self-administration reflect neural activity of the endogenous reward system.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Risinger RC,Salmeron BJ,Ross TJ,Amen SL,Sanfilipo M,Hoffmann RG,Bloom AS,Garavan H,Stein EAdoi
10.1016/j.neuroimage.2005.03.030keywords:
subject
Has Abstractpub_date
2005-07-15 00:00:00pages
1097-108issue
4eissn
1053-8119issn
1095-9572pii
S1053-8119(05)00185-0journal_volume
26pub_type
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