Abstract:
:There is clear evidence that the prefrontal cortex is strongly involved in executive processes and that dopamine can influence performance on working memory tasks. Although, some studies have emphasized the role of striatal dopamine in executive functions, the role played by prefrontal dopamine during executive tasks is unknown. In order to investigate cortical dopamine transmission during executive function, we used D(2)-dopamine receptor ligand [(11)C]FLB 457 PET in healthy subjects while performing the Montreal Card Sorting Task (MCST). During the retrieval with shift task of the MCST, the subjects had to match each test card to one of the reference cards based on a classification rule (color, shape or number) determined by comparing the previously viewed cue card and the current test card. A reduction in [(11)C]FLB 457 binding potential in the right dorsal anterior cingulate cortex (ACC) was observed when subjects performed the active task compared to the control task. These findings may suggest that right dorsal ACC dopamine neurotransmission increases significantly during the performance of certain executive processes, e.g., conflict monitoring, in keeping with previous evidence from fMRI studies showing ACC activation during similar tasks. These results may provide some insights on the origin of cognitive deficits underlying certain neurological disorders associated with dopamine dysfunction, such as Parkinson's disease and schizophrenia.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Ko JH,Ptito A,Monchi O,Cho SS,Van Eimeren T,Pellecchia G,Ballanger B,Rusjan P,Houle S,Strafella APdoi
10.1016/j.neuroimage.2009.02.031subject
Has Abstractpub_date
2009-06-01 00:00:00pages
516-21issue
2eissn
1053-8119issn
1095-9572pii
S1053-8119(09)00187-6journal_volume
46pub_type
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