Abstract:
:Emotional arousal is well-known to enhance memory for individual items or events, whereas it can impair association memory. The neural mechanism of this association memory impairment by emotion is not known: In response to emotionally arousing information, amygdala activity may interfere with hippocampal associative encoding (e.g., via prefrontal cortex). Alternatively, emotional information may be harder to unitize, resulting in reduced availability of extra-hippocampal medial temporal lobe support for emotional than neutral associations. To test these opposing hypotheses, we compared neural processes underlying successful and unsuccessful encoding of emotional and neutral associations. Participants intentionally studied pairs of neutral and negative pictures (Experiments 1-3). We found reduced association-memory for negative pictures in all experiments, accompanied by item-memory increases in Experiment 2. High-resolution fMRI (Experiment 3) indicated that reductions in associative encoding of emotional information are localizable to an area in ventral-lateral amygdala, driven by attentional/salience effects in the central amygdala. Hippocampal activity was similar during both pair types, but a left hippocampal cluster related to successful encoding was observed only for negative pairs. Extra-hippocampal associative memory processes (e.g., unitization) were more effective for neutral than emotional materials. Our findings suggest that reduced emotional association memory is accompanied by increases in activity and functional coupling within the amygdala. This did not disrupt hippocampal association-memory processes, which indeed were critical for successful emotional association memory formation.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Madan CR,Fujiwara E,Caplan JB,Sommer Tdoi
10.1016/j.neuroimage.2017.04.065subject
Has Abstractpub_date
2017-08-01 00:00:00pages
14-28eissn
1053-8119issn
1095-9572pii
S1053-8119(17)30384-1journal_volume
156pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract::The hypothalamus consists of numerous nuclei, and is regarded as the highest center for various autonomic functions. Although each hypothalamic nucleus implements a distinct function, it remains difficult to investigate the human hypothalamus at the nucleus level. In the present high-resolution functional MRI study, w...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.08.056
更新日期:2017-11-15 00:00:00
abstract::Since the introduction of brain mapping, evidences of functional gender differences have been corroborating previous behavioral and neuropsychological results showing a sex-specific brain organization. We investigated gender differences in brain activation during the performance of the Tower of London (TOL) task which...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.07.022
更新日期:2006-11-15 00:00:00
abstract::Learning commonly requires feedback about the consequences of one's actions, which can drive learners to modify their behavior. Motivation may determine how sensitive an individual might be to such feedback, particularly in educational contexts where some students value academic achievement more than others. Thus, mot...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.06.046
更新日期:2015-10-01 00:00:00
abstract::In humans and monkeys the mirror neuron system transforms seen actions into our inner representation of these actions. Here we asked if this system responds also if we see an industrial robot perform similar actions. We localised the motor areas involved in the execution of hand actions, presented the same subjects bl...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.02.003
更新日期:2007-05-01 00:00:00
abstract::Our phenomenological experience of the stable world is maintained by continuous integration of visual self-motion with extra-retinal signals. However, due to conventional constraints of fMRI acquisition in humans, neural responses to visuo-vestibular integration have only been studied using artificial stimuli, in the ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.02.006
更新日期:2018-05-15 00:00:00
abstract::Golgi-impregnated neurons of the human or animal central nervous system were studied with a confocal laser scanning microscope (CLSM). The scanning properties (optical sectioning of the specimen) offered by the CLSM and the capacity of metal granules to reflect the laser beam allow a three-dimensional reconstruction o...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.1993.1002
更新日期:1993-09-01 00:00:00
abstract::Event-related potentials (ERPs) were used to trace changes in brain activity related to progress in second language learning. Twelve English-speaking exchange students learning German in Switzerland were recruited. ERPs to visually presented single words from the subjects' native language (English), second language (G...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.07.008
更新日期:2006-11-01 00:00:00
abstract::The ability to imagine the world from a different viewpoint is a fundamental competence for spatial reorientation and for imagining what another individual sees in the environment. Here, we investigated the neural bases of such an ability using functional magnetic resonance imaging. Healthy participants detected targe...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.10.040
更新日期:2016-01-15 00:00:00
abstract::In the past several years, the number of studies investigating enhancement of cognitive functions through noninvasive brain stimulation (NBS) has increased considerably. NBS techniques, such as transcranial magnetic stimulation and transcranial current stimulation, seem capable of enhancing cognitive functions in pati...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2013.07.038
更新日期:2014-01-15 00:00:00
abstract:BACKGROUND:Volume deficits assessed with magnetic resonance imaging (MRI) and neurochemical dysfunctions (N-acetylaspartate, NAA) diagnosed using proton MR spectroscopy ((1)H-MRS) are reliable observations in the hippocampus of schizophrenic patients. NAA is an important cerebral amino acid in the synthesis pathways of...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.06.006
更新日期:2010-10-15 00:00:00
abstract::The primary goal of this study was to investigate associations between regional gray matter (GM) atrophy and neuropsychological function in multiple sclerosis (MS), while accounting for the influence of central brain atrophy (i.e. third ventricle enlargement). Using a cross-sectional design, we studied 59 MS patients ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.04.017
更新日期:2007-07-15 00:00:00
abstract::The brain's energy economy excessively favors intrinsic, spontaneous neural activity over extrinsic, evoked activity, presumably to maintain its internal organization. Emerging hypotheses capable of explaining such an investment posit that the brain's intrinsic functional architecture encodes a blueprint for its reper...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.10.046
更新日期:2011-02-14 00:00:00
abstract::Connectivity analyses have become increasingly important in functional imaging. When used to describe the functional anatomy of a specific behavior, these analyses are generally applied to a subset of the data that demonstrate significant differences when experimental conditions are contrasted. Such data reduction is ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.09.037
更新日期:2012-02-01 00:00:00
abstract::Cognition is thought to result from interactions within large-scale networks of brain regions. Here, we propose a method to identify these large-scale networks using functional magnetic resonance imaging (fMRI). Regions belonging to such networks are defined as sets of strongly interacting regions, each of which showi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2005.08.044
更新日期:2006-02-15 00:00:00
abstract::In this work, we propose to use fiber tracking in order to analyze and quantify the state of the pyramidal tracts in patients affected by tumors. We introduce a framework that includes an automatic method to obtain the fibers involved in the pyramidal tract of any subject, in order to compare robustly fiber bundles af...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.12.032
更新日期:2010-03-01 00:00:00
abstract::Using contextual information to predict aversive events is a critical ability that protects from generalizing fear responses to safe contexts. Animal models have demonstrated the importance of spatial context representations within the hippocampal formation in contextualization of fear learning. The ventromedial prefr...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116308
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:SPECT imaging with two radiotracers at the same time is feasible if two different radioisotopes are employed, given their distinct energy emission spectra. In the case of 123I and 125I, dual SPECT imaging is not straightforward: 123I emits photons at a principal energy emission spectrum of 143.1-179.9 keV. Howe...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.04.063
更新日期:2018-08-01 00:00:00
abstract::The increase in spatiotemporal resolution of neuroimaging devices is accompanied by a trend towards more powerful multivariate analysis methods. Often it is desired to interpret the outcome of these methods with respect to the cognitive processes under study. Here we discuss which methods allow for such interpretation...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.10.067
更新日期:2014-02-15 00:00:00
abstract::White matter hyperintensities (WMH) are a frequent finding on brain MRI of elderly subjects, and have been associated with various risk factors, as well as with development of cognitive and functional impairment. While an overall association between WMH load and risk factors is well described, possible spatially restr...
journal_title:NeuroImage
pub_type: 杂志文章,多中心研究
doi:10.1016/j.neuroimage.2012.01.106
更新日期:2012-04-15 00:00:00
abstract::Neurofeedback studies using real-time functional magnetic resonance imaging (rt-fMRI) have recently incorporated the multi-voxel pattern decoding approach, allowing for fMRI to serve as a tool to manipulate fine-grained neural activity embedded in voxel patterns. Because of its tremendous potential for clinical applic...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroimage.2017.01.069
更新日期:2017-04-01 00:00:00
abstract::Spatiotemporal filtering and amplification of sensory information at multiple levels during the generation of perceptual representations is a fundamental processing principle of the nervous system. While for the visual and auditory system temporal filtering of sensory signals has been noticed for a long time, respecti...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.09.003
更新日期:2018-12-01 00:00:00
abstract::The modern socio-political climate is defined by conflict between ethnic, religious and political groups: Bosnians and Serbs, Tamils and Singhalese, Irish Catholics and Protestants, Israelis and Arabs. One impediment to the resolution of these conflicts is the psychological bias that members of each group harbor towar...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.05.057
更新日期:2010-10-01 00:00:00
abstract::Developmental differences in brain activation of 9- to 15-year-old children were examined during an auditory rhyme decision task to spoken words using functional magnetic resonance imaging (fMRI). As a group, children showed activation in the left superior/middle temporal gyri (BA 22, 21), right middle temporal gyrus ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2008.02.055
更新日期:2008-06-01 00:00:00
abstract::The rapid adoption of marmosets in neuroscience has created a demand for three dimensional (3D) atlases of the brain of this species to facilitate data integration in a common reference space. We report on a new open access template of the marmoset cortex (the Nencki-Monash, or NM template), representing a morphologic...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117625
更新日期:2021-02-01 00:00:00
abstract::Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) are now being combined to analyze brain function. Confounding the EEG signal acquired in the MR environment is a ballistocardiogram artifact (BA), which is predominantly caused by cardiac-related body movement. The objective of this study wa...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.03.033
更新日期:2004-08-01 00:00:00
abstract::Absence seizures are transient episodes of impaired consciousness accompanied by 3-4 Hz spike-wave discharge on electroencephalography (EEG). Human functional magnetic resonance imaging (fMRI) studies have demonstrated widespread cortical decreases in the blood oxygen-level dependent (BOLD) signal that may play an imp...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.12.066
更新日期:2015-04-01 00:00:00
abstract::Transcranial direct current stimulation (tDCS) can up- and down-regulate cortical excitability depending on current direction, however our abilities to measure brain-tissue effects of the stimulation and its after-effects have been limited so far. We used regional cerebral blood flow (rCBF), a surrogate measure of bra...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.06.018
更新日期:2011-09-01 00:00:00
abstract::In the General Linear Model (GLM) framework for the statistical analysis of fMRI data, the problem of temporal autocorrelations in the residual signal (after regression) has been frequently addressed in the open literature. There exist various methods for correcting the ensuing bias in the statistical testing, among w...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.07.048
更新日期:2004-11-01 00:00:00
abstract::Action is a cover term used to refer to a large set of motor processes differing in domain specificities (e.g. execution or observation). Here we review neuroimaging evidence on action processing (N = 416; Subjects = 5912) using quantitative Activation Likelihood Estimation (ALE) and Meta-Analytic Connectivity Modelin...
journal_title:NeuroImage
pub_type: 杂志文章,meta分析
doi:10.1016/j.neuroimage.2019.116321
更新日期:2020-02-01 00:00:00
abstract::Amygdala responses to emotional faces can be influenced by concomitant gaze direction. As an explanation it has been suggested that the observer uses eye gaze as a cue to decipher the source of a potential threat in order to evaluate the significance of the situation. To test this assumption, we kept gaze direction am...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.02.021
更新日期:2011-05-01 00:00:00