Emotional arousal impairs association-memory: Roles of amygdala and hippocampus.

Abstract:

:Emotional arousal is well-known to enhance memory for individual items or events, whereas it can impair association memory. The neural mechanism of this association memory impairment by emotion is not known: In response to emotionally arousing information, amygdala activity may interfere with hippocampal associative encoding (e.g., via prefrontal cortex). Alternatively, emotional information may be harder to unitize, resulting in reduced availability of extra-hippocampal medial temporal lobe support for emotional than neutral associations. To test these opposing hypotheses, we compared neural processes underlying successful and unsuccessful encoding of emotional and neutral associations. Participants intentionally studied pairs of neutral and negative pictures (Experiments 1-3). We found reduced association-memory for negative pictures in all experiments, accompanied by item-memory increases in Experiment 2. High-resolution fMRI (Experiment 3) indicated that reductions in associative encoding of emotional information are localizable to an area in ventral-lateral amygdala, driven by attentional/salience effects in the central amygdala. Hippocampal activity was similar during both pair types, but a left hippocampal cluster related to successful encoding was observed only for negative pairs. Extra-hippocampal associative memory processes (e.g., unitization) were more effective for neutral than emotional materials. Our findings suggest that reduced emotional association memory is accompanied by increases in activity and functional coupling within the amygdala. This did not disrupt hippocampal association-memory processes, which indeed were critical for successful emotional association memory formation.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Madan CR,Fujiwara E,Caplan JB,Sommer T

doi

10.1016/j.neuroimage.2017.04.065

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

14-28

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(17)30384-1

journal_volume

156

pub_type

杂志文章
  • Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism.

    abstract::The hypothalamus consists of numerous nuclei, and is regarded as the highest center for various autonomic functions. Although each hypothalamic nucleus implements a distinct function, it remains difficult to investigate the human hypothalamus at the nucleus level. In the present high-resolution functional MRI study, w...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2017.08.056

    authors: Osada T,Suzuki R,Ogawa A,Tanaka M,Hori M,Aoki S,Tamura Y,Watada H,Kawamori R,Konishi S

    更新日期:2017-11-15 00:00:00

  • The effect of gender on planning: An fMRI study using the Tower of London task.

    abstract::Since the introduction of brain mapping, evidences of functional gender differences have been corroborating previous behavioral and neuropsychological results showing a sex-specific brain organization. We investigated gender differences in brain activation during the performance of the Tower of London (TOL) task which...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2006.07.022

    authors: Boghi A,Rasetti R,Avidano F,Manzone C,Orsi L,D'Agata F,Caroppo P,Bergui M,Rocca P,Pulvirenti L,Bradac GB,Bogetto F,Mutani R,Mortara P

    更新日期:2006-11-15 00:00:00

  • Effects of intrinsic motivation on feedback processing during learning.

    abstract::Learning commonly requires feedback about the consequences of one's actions, which can drive learners to modify their behavior. Motivation may determine how sensitive an individual might be to such feedback, particularly in educational contexts where some students value academic achievement more than others. Thus, mot...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2015.06.046

    authors: DePasque S,Tricomi E

    更新日期:2015-10-01 00:00:00

  • The anthropomorphic brain: the mirror neuron system responds to human and robotic actions.

    abstract::In humans and monkeys the mirror neuron system transforms seen actions into our inner representation of these actions. Here we asked if this system responds also if we see an industrial robot perform similar actions. We localised the motor areas involved in the execution of hand actions, presented the same subjects bl...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2007.02.003

    authors: Gazzola V,Rizzolatti G,Wicker B,Keysers C

    更新日期:2007-05-01 00:00:00

  • Integration of visual and non-visual self-motion cues during voluntary head movements in the human brain.

    abstract::Our phenomenological experience of the stable world is maintained by continuous integration of visual self-motion with extra-retinal signals. However, due to conventional constraints of fMRI acquisition in humans, neural responses to visuo-vestibular integration have only been studied using artificial stimuli, in the ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2018.02.006

    authors: Schindler A,Bartels A

    更新日期:2018-05-15 00:00:00

  • Real complete three-dimensional reconstruction of Golgi-impregnated neurons by means of a confocal laser scanning microscope.

    abstract::Golgi-impregnated neurons of the human or animal central nervous system were studied with a confocal laser scanning microscope (CLSM). The scanning properties (optical sectioning of the specimen) offered by the CLSM and the capacity of metal granules to reflect the laser beam allow a three-dimensional reconstruction o...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1006/nimg.1993.1002

    authors: Tredici G,Di Francesco A,Miani A Jr,Pizzini G

    更新日期:1993-09-01 00:00:00

  • Plasticity in the adult language system: a longitudinal electrophysiological study on second language learning.

    abstract::Event-related potentials (ERPs) were used to trace changes in brain activity related to progress in second language learning. Twelve English-speaking exchange students learning German in Switzerland were recruited. ERPs to visually presented single words from the subjects' native language (English), second language (G...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2006.07.008

    authors: Stein M,Dierks T,Brandeis D,Wirth M,Strik W,Koenig T

    更新日期:2006-11-01 00:00:00

  • Role of the human retrosplenial cortex/parieto-occipital sulcus in perspective priming.

    abstract::The ability to imagine the world from a different viewpoint is a fundamental competence for spatial reorientation and for imagining what another individual sees in the environment. Here, we investigated the neural bases of such an ability using functional magnetic resonance imaging. Healthy participants detected targe...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2015.10.040

    authors: Sulpizio V,Committeri G,Lambrey S,Berthoz A,Galati G

    更新日期:2016-01-15 00:00:00

  • Is neuroenhancement by noninvasive brain stimulation a net zero-sum proposition?

    abstract::In the past several years, the number of studies investigating enhancement of cognitive functions through noninvasive brain stimulation (NBS) has increased considerably. NBS techniques, such as transcranial magnetic stimulation and transcranial current stimulation, seem capable of enhancing cognitive functions in pati...

    journal_title:NeuroImage

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroimage.2013.07.038

    authors: Brem AK,Fried PJ,Horvath JC,Robertson EM,Pascual-Leone A

    更新日期:2014-01-15 00:00:00

  • Interaction of hippocampal volume and N-acetylaspartate concentration deficits in schizophrenia: a combined MRI and 1H-MRS study.

    abstract:BACKGROUND:Volume deficits assessed with magnetic resonance imaging (MRI) and neurochemical dysfunctions (N-acetylaspartate, NAA) diagnosed using proton MR spectroscopy ((1)H-MRS) are reliable observations in the hippocampus of schizophrenic patients. NAA is an important cerebral amino acid in the synthesis pathways of...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2010.06.006

    authors: Klär AA,Ballmaier M,Leopold K,Häke I,Schaefer M,Brühl R,Schubert F,Gallinat J

    更新日期:2010-10-15 00:00:00

  • Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis.

    abstract::The primary goal of this study was to investigate associations between regional gray matter (GM) atrophy and neuropsychological function in multiple sclerosis (MS), while accounting for the influence of central brain atrophy (i.e. third ventricle enlargement). Using a cross-sectional design, we studied 59 MS patients ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2007.04.017

    authors: Tekok-Kilic A,Benedict RH,Weinstock-Guttman B,Dwyer MG,Carone D,Srinivasaraghavan B,Yella V,Abdelrahman N,Munschauer F,Bakshi R,Zivadinov R

    更新日期:2007-07-15 00:00:00

  • Linking inter-individual differences in neural activation and behavior to intrinsic brain dynamics.

    abstract::The brain's energy economy excessively favors intrinsic, spontaneous neural activity over extrinsic, evoked activity, presumably to maintain its internal organization. Emerging hypotheses capable of explaining such an investment posit that the brain's intrinsic functional architecture encodes a blueprint for its reper...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2010.10.046

    authors: Mennes M,Zuo XN,Kelly C,Di Martino A,Zang YF,Biswal B,Castellanos FX,Milham MP

    更新日期:2011-02-14 00:00:00

  • Performance-based connectivity analysis: a path to convergence with clinical studies.

    abstract::Connectivity analyses have become increasingly important in functional imaging. When used to describe the functional anatomy of a specific behavior, these analyses are generally applied to a subset of the data that demonstrate significant differences when experimental conditions are contrasted. Such data reduction is ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2011.09.037

    authors: Sidtis JJ

    更新日期:2012-02-01 00:00:00

  • Identification of large-scale networks in the brain using fMRI.

    abstract::Cognition is thought to result from interactions within large-scale networks of brain regions. Here, we propose a method to identify these large-scale networks using functional magnetic resonance imaging (fMRI). Regions belonging to such networks are defined as sets of strongly interacting regions, each of which showi...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2005.08.044

    authors: Bellec P,Perlbarg V,Jbabdi S,Pélégrini-Issac M,Anton JL,Doyon J,Benali H

    更新日期:2006-02-15 00:00:00

  • Analysis of the pyramidal tract in tumor patients using diffusion tensor imaging.

    abstract::In this work, we propose to use fiber tracking in order to analyze and quantify the state of the pyramidal tracts in patients affected by tumors. We introduce a framework that includes an automatic method to obtain the fibers involved in the pyramidal tract of any subject, in order to compare robustly fiber bundles af...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2009.12.032

    authors: Cárdenes R,Muñoz-Moreno E,Sarabia-Herrero R,Rodríguez-Velasco M,Fuertes-Alija JJ,Martin-Fernandez M

    更新日期:2010-03-01 00:00:00

  • The role of hippocampal spatial representations in contextualization and generalization of fear.

    abstract::Using contextual information to predict aversive events is a critical ability that protects from generalizing fear responses to safe contexts. Animal models have demonstrated the importance of spatial context representations within the hippocampal formation in contextualization of fear learning. The ventromedial prefr...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2019.116308

    authors: de Voogd LD,Murray YPJ,Barte RM,van der Heide A,Fernández G,Doeller CF,Hermans EJ

    更新日期:2020-02-01 00:00:00

  • Dual-radiotracer translational SPECT neuroimaging. Comparison of three methods for the simultaneous brain imaging of D2/3 and 5-HT2A receptors.

    abstract:PURPOSE:SPECT imaging with two radiotracers at the same time is feasible if two different radioisotopes are employed, given their distinct energy emission spectra. In the case of 123I and 125I, dual SPECT imaging is not straightforward: 123I emits photons at a principal energy emission spectrum of 143.1-179.9 keV. Howe...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2018.04.063

    authors: Tsartsalis S,Tournier BB,Habiby S,Ben Hamadi M,Barca C,Ginovart N,Millet P

    更新日期:2018-08-01 00:00:00

  • On the interpretation of weight vectors of linear models in multivariate neuroimaging.

    abstract::The increase in spatiotemporal resolution of neuroimaging devices is accompanied by a trend towards more powerful multivariate analysis methods. Often it is desired to interpret the outcome of these methods with respect to the cognitive processes under study. Here we discuss which methods allow for such interpretation...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2013.10.067

    authors: Haufe S,Meinecke F,Görgen K,Dähne S,Haynes JD,Blankertz B,Bießmann F

    更新日期:2014-02-15 00:00:00

  • The spatial distribution of age-related white matter changes as a function of vascular risk factors--results from the LADIS study.

    abstract::White matter hyperintensities (WMH) are a frequent finding on brain MRI of elderly subjects, and have been associated with various risk factors, as well as with development of cognitive and functional impairment. While an overall association between WMH load and risk factors is well described, possible spatially restr...

    journal_title:NeuroImage

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.neuroimage.2012.01.106

    authors: Rostrup E,Gouw AA,Vrenken H,van Straaten EC,Ropele S,Pantoni L,Inzitari D,Barkhof F,Waldemar G,LADIS study group.

    更新日期:2012-04-15 00:00:00

  • Decoded fMRI neurofeedback can induce bidirectional confidence changes within single participants.

    abstract::Neurofeedback studies using real-time functional magnetic resonance imaging (rt-fMRI) have recently incorporated the multi-voxel pattern decoding approach, allowing for fMRI to serve as a tool to manipulate fine-grained neural activity embedded in voxel patterns. Because of its tremendous potential for clinical applic...

    journal_title:NeuroImage

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.neuroimage.2017.01.069

    authors: Cortese A,Amano K,Koizumi A,Lau H,Kawato M

    更新日期:2017-04-01 00:00:00

  • Evidence for a spinal involvement in temporal pain contrast enhancement.

    abstract::Spatiotemporal filtering and amplification of sensory information at multiple levels during the generation of perceptual representations is a fundamental processing principle of the nervous system. While for the visual and auditory system temporal filtering of sensory signals has been noticed for a long time, respecti...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2018.09.003

    authors: Sprenger C,Stenmans P,Tinnermann A,Büchel C

    更新日期:2018-12-01 00:00:00

  • Attitudes towards the outgroup are predicted by activity in the precuneus in Arabs and Israelis.

    abstract::The modern socio-political climate is defined by conflict between ethnic, religious and political groups: Bosnians and Serbs, Tamils and Singhalese, Irish Catholics and Protestants, Israelis and Arabs. One impediment to the resolution of these conflicts is the psychological bias that members of each group harbor towar...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2010.05.057

    authors: Bruneau EG,Saxe R

    更新日期:2010-10-01 00:00:00

  • Developmental changes in brain regions involved in phonological and orthographic processing during spoken language processing.

    abstract::Developmental differences in brain activation of 9- to 15-year-old children were examined during an auditory rhyme decision task to spoken words using functional magnetic resonance imaging (fMRI). As a group, children showed activation in the left superior/middle temporal gyri (BA 22, 21), right middle temporal gyrus ...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2008.02.055

    authors: Cone NE,Burman DD,Bitan T,Bolger DJ,Booth JR

    更新日期:2008-06-01 00:00:00

  • Histology-Based Average Template of the Marmoset Cortex With Probabilistic Localization of Cytoarchitectural Areas.

    abstract::The rapid adoption of marmosets in neuroscience has created a demand for three dimensional (3D) atlases of the brain of this species to facilitate data integration in a common reference space. We report on a new open access template of the marmoset cortex (the Nencki-Monash, or NM template), representing a morphologic...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2020.117625

    authors: Majka P,Bednarek S,Chan JM,Jermakow N,Liu C,Saworska G,Worthy KH,Silva AC,Wójcik DK,Rosa MGP

    更新日期:2021-02-01 00:00:00

  • Ballistocardiogram artifact reduction in the simultaneous acquisition of auditory ERPS and fMRI.

    abstract::Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) are now being combined to analyze brain function. Confounding the EEG signal acquired in the MR environment is a ballistocardiogram artifact (BA), which is predominantly caused by cardiac-related body movement. The objective of this study wa...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2004.03.033

    authors: Ellingson ML,Liebenthal E,Spanaki MV,Prieto TE,Binder JR,Ropella KM

    更新日期:2004-08-01 00:00:00

  • Rhythmic 3-4Hz discharge is insufficient to produce cortical BOLD fMRI decreases in generalized seizures.

    abstract::Absence seizures are transient episodes of impaired consciousness accompanied by 3-4 Hz spike-wave discharge on electroencephalography (EEG). Human functional magnetic resonance imaging (fMRI) studies have demonstrated widespread cortical decreases in the blood oxygen-level dependent (BOLD) signal that may play an imp...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2014.12.066

    authors: Youngblood MW,Chen WC,Mishra AM,Enamandram S,Sanganahalli BG,Motelow JE,Bai HX,Frohlich F,Gribizis A,Lighten A,Hyder F,Blumenfeld H

    更新日期:2015-04-01 00:00:00

  • Effects of transcranial direct current stimulation (tDCS) on human regional cerebral blood flow.

    abstract::Transcranial direct current stimulation (tDCS) can up- and down-regulate cortical excitability depending on current direction, however our abilities to measure brain-tissue effects of the stimulation and its after-effects have been limited so far. We used regional cerebral blood flow (rCBF), a surrogate measure of bra...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2011.06.018

    authors: Zheng X,Alsop DC,Schlaug G

    更新日期:2011-09-01 00:00:00

  • Optimal spatial regularisation of autocorrelation estimates in fMRI analysis.

    abstract::In the General Linear Model (GLM) framework for the statistical analysis of fMRI data, the problem of temporal autocorrelations in the residual signal (after regression) has been frequently addressed in the open literature. There exist various methods for correcting the ensuing bias in the statistical testing, among w...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2004.07.048

    authors: Gautama T,Van Hulle MM

    更新日期:2004-11-01 00:00:00

  • The topographical organization of motor processing: An ALE meta-analysis on six action domains and the relevance of Broca's region.

    abstract::Action is a cover term used to refer to a large set of motor processes differing in domain specificities (e.g. execution or observation). Here we review neuroimaging evidence on action processing (N = 416; Subjects = 5912) using quantitative Activation Likelihood Estimation (ALE) and Meta-Analytic Connectivity Modelin...

    journal_title:NeuroImage

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.neuroimage.2019.116321

    authors: Papitto G,Friederici AD,Zaccarella E

    更新日期:2020-02-01 00:00:00

  • Processing of facial expressions and their significance for the observer in subregions of the human amygdala.

    abstract::Amygdala responses to emotional faces can be influenced by concomitant gaze direction. As an explanation it has been suggested that the observer uses eye gaze as a cue to decipher the source of a potential threat in order to evaluate the significance of the situation. To test this assumption, we kept gaze direction am...

    journal_title:NeuroImage

    pub_type: 杂志文章

    doi:10.1016/j.neuroimage.2011.02.021

    authors: Boll S,Gamer M,Kalisch R,Büchel C

    更新日期:2011-05-01 00:00:00