Abstract：
:We present a multi-scale generative model for EEG, that entails a minimum number of assumptions about evoked brain responses, namely: (1) bioelectric activity is generated by a set of distributed sources, (2) the dynamics of these sources can be modelled as random fluctuations about a small number of mesostates, (3) mesostates evolve in a temporal structured way and are functionally connected (i.e. influence each other), and (4) the number of mesostates engaged by a cognitive task is small (e.g. between one and a few). A Variational Bayesian learning scheme is described that furnishes the posterior density on the models parameters and its evidence. Since the number of meso-sources specifies the model, the model evidence can be used to compare models and find the optimum number of meso-sources. In addition to estimating the dynamics at each cortical dipole, the mesostate-space model and its inversion provide a description of brain activity at the level of the mesostates (i.e. in terms of the dynamics of meso-sources that are distributed over dipoles). The inclusion of a mesostate level allows one to compute posterior probability maps of each dipole being active (i.e. belonging to an active mesostate). Critically, this model accommodates constraints on the number of meso-sources, while retaining the flexibility of distributed source models in explaining data. In short, it bridges the gap between standard distributed and equivalent current dipole models. Furthermore, because it is explicitly spatiotemporal, the model can embed any stochastic dynamical causal model (e.g. a neural mass model) as a Markov process prior on the mesostate dynamics. The approach is evaluated and compared to standard inverse EEG techniques, using synthetic data and real data. The results demonstrate the added-value of the mesostate-space model and its variational inversion.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Daunizeau J,Friston KJdoi
10.1016/j.neuroimage.2007.06.034subject
Has Abstractpub_date
2007-10-15 00:00:00pages
67-81issue
1eissn
1053-8119issn
1095-9572pii
S1053-8119(07)00568-Xjournal_volume
38pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract：:The study of congenitally deaf individuals provides a unique opportunity to understand the organization and potential for reorganization of human auditory cortex. We used magnetic resonance imaging (MRI) to examine the structural organization of two auditory cortical regions, Heschl's gyrus (HG) and the planum tempora...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/S1053-8119(03)00373-2
更新日期：2003-10-01 00:00:00
abstract：:Visual integration between target and irrelevant features leads to effects of irrelevant feature congruency (Stroop) or variation (Garner) on target classification performance. Presenting closed geometrical shapes as stimuli, we obtained Stroop and Garner effects of one part of their contour on another, in response ti...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.01.019
更新日期：2009-05-01 00:00:00
abstract：:Functional transcranial Doppler sonography (fTCD) adds to the techniques of functional imaging. fTCD measures cerebral perfusion changes related to neural activation in a way comparable to functional magnetic resonance tomography. fTCD contends itself with comparison of averaged, event-related blood flow velocity chan...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2003.10.016
更新日期：2004-03-01 00:00:00
abstract：:Dynamic functional connectivity (DFC) aims to maximize resolvable information from functional brain scans by considering temporal changes in network structure. Recent work has demonstrated that static, i.e. time-invariant resting-state and task-based FC predicts individual differences in behavior, including attention....
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2018.11.057
更新日期：2019-03-01 00:00:00
abstract：:We present a novel method for detecting frequency-frequency coupling between the electrical output of cortical areas as measured by electrocorticography (ECoG), electroencephalography (EEG) and magnetoencephalography (MEG), the biphase-locking value (bPLV). Our method is an extension of the well known phase-locking va...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.01.034
更新日期：2009-05-15 00:00:00
abstract：:Models of healthy brain function and psychiatric conditions assume that excitatory and inhibitory activity are balanced in the human brain at multiple spatial and temporal scales. In human neuroimaging, concentrations of the major excitatory (glutamate) and inhibitory (γ-aminobutyric acid, GABA) neurotransmitters are ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.117112
更新日期：2020-10-15 00:00:00
abstract：:According to a classical view of visual object recognition, targets are detected "pre-attentively" if they carry unique features, whereas attention has to be deployed serially to object locations for feature binding if the targets can be distinguished from distracters only in terms of their feature conjunctions. Consi...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1006/nimg.2001.0951
更新日期：2002-01-01 00:00:00
abstract：:In this paper we present a novel wavelet-based Bayesian nonparametric regression model for the analysis of functional magnetic resonance imaging (fMRI) data. Our goal is to provide a joint analytical framework that allows to detect regions of the brain which exhibit neuronal activity in response to a stimulus and, sim...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.03.024
更新日期：2014-07-15 00:00:00
abstract：:Pathological changes of penetrating arteries (PA) within the centrum semiovale is an important contributing factor of cerebral small vessel disease (SVD). However, quantitative characterization of the PAs remains challenging due to their sub-voxel sizes. Here, we proposed a Model-based Analysis of Complex Difference i...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.03.059
更新日期：2019-07-15 00:00:00
abstract：:Macroscopic models of brain networks typically incorporate assumptions regarding the characteristics of afferent noise, which is used to represent input from distal brain regions or ongoing fluctuations in non-modelled parts of the brain. Such inputs are often modelled by Gaussian white noise which has a flat power sp...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.11.034
更新日期：2017-02-01 00:00:00
abstract：:The 1990s were designated "The Decade of the Brain" by U.S. Congress, perhaps in great anticipation of the impact that functional neuroimaging techniques would have on advancing our understanding of how the brain is functionally organized. While it is impossible to overestimate the impact of functional MRI in neurosci...
journal_title：NeuroImage
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.neuroimage.2012.01.008
更新日期：2012-08-15 00:00:00
abstract：:Spatial navigation is a crucial ability for living. Previous studies have shown that males are better at navigation than females, but little is known about the neural basis underlying the sex differences. In this study, we investigated whether cortical scene processing in three well-established scene-selective regions...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.07.031
更新日期：2017-09-01 00:00:00
abstract：:Normal brain development depends on early sensory experience. Behavioral consequences of brain maturation in the absence of sensory input early in life are well documented. For example, experiments with mature, neonatally deaf human or animal subjects have revealed improved peripheral visual motion detection and spati...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.10.002
更新日期：2018-01-15 00:00:00
abstract：:The ability to select and integrate relevant information in the presence of competing irrelevant information can be enhanced by advance information to direct attention and guide response selection. Attentional preparation can reduce perceptual and response conflict, yet little is known about the neural source of confl...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.06.058
更新日期：2009-11-01 00:00:00
abstract：UNLABELLED:Functional magnetic resonance imaging (fMRI) studies have revealed the existence of robust, interconnected brain networks exhibiting correlated low frequency fluctuations during rest, which can be derived by examining inherent spatio-temporal patterns in functional scans independent of any a priori model. In...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2015.05.051
更新日期：2015-09-01 00:00:00
abstract：:Attention-related amplification of neural representations of external stimuli has been well documented in the visual domain, however, research concerning the oscillatory dynamics of such directed attention is relatively sparse in humans. Specifically, it is unknown which spectrally-specific neural responses are mainly...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.116927
更新日期：2020-08-15 00:00:00
abstract：:The anterior cingulate cortex (ACC) is implicated in performance monitoring and cognitive control. Non-human primate studies of ACC show prominent reward signals, but these are elusive in human studies, which instead show mainly conflict and error effects. Here we demonstrate distinct appetitive and aversive activity ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.11.065
更新日期：2010-02-15 00:00:00
abstract：:The superior capability of chess experts largely depends on quick automatic processing skills which are considered to be mediated by the caudate nucleus. We asked whether continued practice or rehearsal of the skill over a long period of time can lead to structural changes in this region. We found that, comparing to n...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.01.047
更新日期：2012-04-02 00:00:00
abstract：:The diffusion tensor is a commonly used model for diffusion-weighted MR image data. The parameters are typically estimated by ordinary or weighted least squares on log-transformed data, assuming normal or log-normal distribution of measurement errors respectively. This may not be adequate when using high b-values and ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.05.053
更新日期：2008-10-01 00:00:00
abstract：:Characterization and quantification of magnetic resonance perfusion images is important for clinical interpretation, though this calls for a reproducible and accurate method of analysis and a robust healthy reference. The few studies which have examined the perfusion of the healthy brain using dynamic susceptibility c...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.03.027
更新日期：2011-06-01 00:00:00
abstract：:During auditory perception, we are required to abstract information from complex temporal sequences such as those in music and speech. Here, we investigated how higher-order statistics modulate the neural responses to sound sequences, hypothesizing that these modulations are associated with higher levels of the peri-S...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.10.038
更新日期：2011-02-01 00:00:00
abstract：:Increasing attention has recently been directed to the applications of pattern recognition and brain imaging techniques in the effective and accurate diagnosis of Alzheimer's disease (AD). However, most of the existing research focuses on the use of single-modal (e.g., structural or functional MRI) or single-level (e....
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.10.003
更新日期：2012-02-01 00:00:00
abstract：:Reliable quantification of white matter hyperintensities of presumed vascular origin (WMHs) is increasingly needed, given the presence of these MRI findings in patients with several neurological and vascular disorders, as well as in elderly healthy subjects. We present BIANCA (Brain Intensity AbNormality Classificatio...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.07.018
更新日期：2016-11-01 00:00:00
abstract：:The present study reported the development of a novel functional photoacoustic microscopy (fPAM) system for investigating hemodynamic changes in rat cortical vessels associated with electrical forepaw stimulation. Imaging of blood optical absorption by fPAM at multiple appropriately-selected and distinct wavelengths c...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.03.065
更新日期：2010-08-15 00:00:00
abstract：:This article reviews studies demonstrating enhancement with transcranial direct current stimulation (tDCS) of attention, learning, and memory processes in healthy adults. Given that these are fundamental cognitive functions, they may also mediate stimulation effects on other higher-order processes such as decision-mak...
journal_title：NeuroImage
pub_type： 杂志文章,评审
doi：10.1016/j.neuroimage.2013.07.083
更新日期：2014-01-15 00:00:00
abstract：:Alzheimer's disease (AD) is known to cause a variety of disturbances of higher visual functions that are closely related to the neuropathological changes. Visual association areas are more affected than primary visual cortex. Additionally, there is evidence from neuropsychological and imaging studies during rest or pa...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1006/nimg.2002.1271
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND:Quantitative MRI (qMRI) techniques allow assessing cerebral tissue properties. However, previous studies on the accuracy of quantitative T1 and T2 mapping reported a scanner model bias of up to 10% for T1 and up to 23% for T2. Such differences would render multi-centre qMRI studies difficult and raise fundam...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.116364
更新日期：2020-02-15 00:00:00
abstract：:The present fMRI study investigated the hypothesis that activation of the left ventral occipitotemporal cortex (vOT) in response to auditory words can be attributed to lexical orthographic rather than lexico-semantic processing. To this end, we presented auditory words in both an orthographic ("three or four letter wo...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.09.039
更新日期：2016-01-01 00:00:00
abstract：:Language lateralization based on functional magnetic resonance imaging (fMRI) is often used in clinical neurological settings. Currently, interpretation of the distribution, pattern and extent of language activation can be heavily dependent on the chosen statistical threshold. The aim of the present study was to 1) te...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.01.059
更新日期：2010-05-01 00:00:00
abstract：:Vocal expressions commonly elicit activity in superior temporal and inferior frontal cortices, indicating a distributed network to decode vocally expressed emotions. We examined the involvement of this fronto-temporal network for the decoding of angry voices during attention towards (explicit attention) or away from e...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.06.015
更新日期：2012-09-01 00:00:00
