Abstract:
:The aim of this study was to explore non-invasive imaging methods to detect post-injury structural axonal plasticity. Brain injury was launched by status epilepticus induced by intraperitoneal injection of either kainic acid or pilocarpine. Several months later, ex vivo diffusion tensor magnetic resonance imaging (DTI) showed increased FA in the dentate gyrus of both kainic acid (p<0.01) and pilocarpine animals (p<0.01). Importantly, FA changes correlated (p<0.01) with histologically verified axonal plasticity of myelinated and non-myelinated neuronal fibers. The changes observed in DTI parameters ex vivo in the septal dentate gyrus were also seen by in vivo DTI. As DTI is completely a non-invasive imaging method, these results may pave the way for non-invasive in vivo imaging of axonal plasticity after brain insults.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Laitinen T,Sierra A,Pitkänen A,Gröhn Odoi
10.1016/j.neuroimage.2010.02.077subject
Has Abstractpub_date
2010-06-01 00:00:00pages
521-30issue
2eissn
1053-8119issn
1095-9572pii
S1053-8119(10)00264-8journal_volume
51pub_type
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