Cortical functional connectivity indexes arousal state during sleep and anesthesia.


:Disruption of cortical connectivity likely contributes to loss of consciousness (LOC) during both sleep and general anesthesia, but the degree of overlap in the underlying mechanisms is unclear. Both sleep and anesthesia comprise states of varying levels of arousal and consciousness, including states of largely maintained conscious experience (sleep: N1, REM; anesthesia: sedated but responsive) as well as states of substantially reduced conscious experience (sleep: N2/N3; anesthesia: unresponsive). Here, we tested the hypotheses that (1) cortical connectivity will exhibit clear changes when transitioning into states of reduced consciousness, and (2) these changes will be similar for arousal states of comparable levels of consciousness during sleep and anesthesia. Using intracranial recordings from five adult neurosurgical patients, we compared resting state cortical functional connectivity (as measured by weighted phase lag index, wPLI) in the same subjects across arousal states during natural sleep [wake (WS), N1, N2, N3, REM] and propofol anesthesia [pre-drug wake (WA), sedated/responsive (S), and unresponsive (U)]. Analysis of alpha-band connectivity indicated a transition boundary distinguishing states of maintained and reduced conscious experience in both sleep and anesthesia. In wake states WS and WA, alpha-band wPLI within the temporal lobe was dominant. This pattern was largely unchanged in N1, REM, and S. Transitions into states of reduced consciousness N2, N3, and U were characterized by dramatic changes in connectivity, with dominant connections shifting to prefrontal cortex. Secondary analyses indicated similarities in reorganization of cortical connectivity in sleep and anesthesia. Shifts from temporal to frontal cortical connectivity may reflect impaired sensory processing in states of reduced consciousness. The data indicate that functional connectivity can serve as a biomarker of arousal state and suggest common mechanisms of LOC in sleep and anesthesia.






Banks MI,Krause BM,Endemann CM,Campbell DI,Kovach CK,Dyken ME,Kawasaki H,Nourski KV




Has Abstract


2020-05-01 00:00:00












  • Neuroplasticity and MRI: A perfect match.

    abstract::Numerous studies have illustrated the benefits of physical workout and cognitive exercise on brain function and structure and, more importantly, on decelerating cognitive decline in old age and promoting functional rehabilitation following injury. Despite these behavioral observations, the exact mechanisms underlying ...


    pub_type: 杂志文章,评审


    authors: Hamaide J,De Groof G,Van der Linden A

    更新日期:2016-05-01 00:00:00

  • EEG correlates of time-varying BOLD functional connectivity.

    abstract::Recent resting-state fMRI studies have shown that the apparent functional connectivity (FC) between brain regions may undergo changes on time-scales of seconds to minutes, the basis and importance of which are largely unknown. Here, we examine the electrophysiological correlates of within-scan FC variations during a c...


    pub_type: 杂志文章


    authors: Chang C,Liu Z,Chen MC,Liu X,Duyn JH

    更新日期:2013-05-15 00:00:00

  • Connectopic mapping with resting-state fMRI.

    abstract::Brain regions are often topographically connected: nearby locations within one brain area connect with nearby locations in another area. Mapping these connection topographies, or 'connectopies' in short, is crucial for understanding how information is processed in the brain. Here, we propose principled, fully data-dri...


    pub_type: 杂志文章,评审


    authors: Haak KV,Marquand AF,Beckmann CF

    更新日期:2018-04-15 00:00:00

  • Functional connectivity of the human insular cortex during noxious and innocuous thermal stimulation.

    abstract::The insula plays a key role in brain processing of noxious and innocuous thermal stimuli. The anterior and the posterior portions of the insular cortex are involved in different ways in nociceptive and thermoceptive processing. Therefore, their stimulus-specific functional connectivity may also differ. Here we used fu...


    pub_type: 杂志文章


    authors: Peltz E,Seifert F,DeCol R,Dörfler A,Schwab S,Maihöfner C

    更新日期:2011-01-15 00:00:00

  • Increased functional connectivity between language and visually deprived areas in late and partial blindness.

    abstract::In the congenitally blind, language processing involves visual areas. In the case of normal visual development however, it remains unclear whether later visual loss induces interactions between the language and visual areas. This study compared the resting-state functional connectivity (FC) of retinotopic and language...


    pub_type: 杂志文章


    authors: Sabbah N,Authié CN,Sanda N,Mohand-Saïd S,Sahel JA,Safran AB,Habas C,Amedi A

    更新日期:2016-08-01 00:00:00

  • In vivo tracing of major rat brain pathways using manganese-enhanced magnetic resonance imaging and three-dimensional digital atlasing.

    abstract::The magnetic resonance imaging (MRI)-detectable T1 contrast agent manganese (Mn2+) has recently been introduced as a neural tracer in rodents, birds, and monkeys. We have tested to what extent this in vivo method is useful for three-dimensional (3-D) survey of connectivity patterns in the rat somatosensory system. A c...


    pub_type: 杂志文章


    authors: Leergaard TB,Bjaalie JG,Devor A,Wald LL,Dale AM

    更新日期:2003-11-01 00:00:00

  • Correlations between FDG PET glucose uptake-MRI gray matter volume scores and apolipoprotein E ε4 gene dose in cognitively normal adults: a cross-validation study using voxel-based multi-modal partial least squares.

    abstract::We previously introduced a voxel-based, multi-modal application of the partial least square algorithm (MMPLS) to characterize the linkage between patterns in a person's complementary complex datasets without the need to correct for multiple regional comparisons. Here we used it to demonstrate a strong correlation betw...


    pub_type: 杂志文章


    authors: Chen K,Ayutyanont N,Langbaum JB,Fleisher AS,Reschke C,Lee W,Liu X,Alexander GE,Bandy D,Caselli RJ,Reiman EM

    更新日期:2012-05-01 00:00:00

  • Inhibiting mGluR5 activity by AFQ056/Mavoglurant rescues circuit-specific functional connectivity in Fmr1 knockout mice.

    abstract::Previous work has demonstrated that neuroimaging biomarkers which capture functional connectivity of the brain can be used to define a specific and robust endophenotype in Fmr1-/y mice, a well-established animal model of human Fragile-X Syndrome (FXS). However, it is currently unknown whether this macroscopic measure ...


    pub_type: 杂志文章


    authors: Zerbi V,Markicevic M,Gasparini F,Schroeter A,Rudin M,Wenderoth N

    更新日期:2019-05-01 00:00:00

  • Performance measure characterization for evaluating neuroimage segmentation algorithms.

    abstract::Characterizing the performance of segmentation algorithms in brain images has been a persistent challenge due to the complexity of neuroanatomical structures, the quality of imagery and the requirement of accurate segmentation. There has been much interest in using the Jaccard and Dice similarity coefficients associat...


    pub_type: 杂志文章


    authors: Chang HH,Zhuang AH,Valentino DJ,Chu WC

    更新日期:2009-08-01 00:00:00

  • Interacting sources of interference during sensorimotor integration processes.

    abstract::Every day, a multitude of interfering sensory inputs needs to be integrated and adequately processed using response selection processes. Interference effects are typically investigated using classical paradigms like the Flanker and Simon task. The sources of interference for Flanker and Simon effect are known to be di...


    pub_type: 杂志文章


    authors: Mückschel M,Stock AK,Dippel G,Chmielewski W,Beste C

    更新日期:2016-01-15 00:00:00

  • A rotation-invariant spherical harmonic decomposition method for mapping intravoxel multiple fiber structures.

    abstract::A new rotation-invariant spherical harmonic decomposition (SHD) method is proposed in this paper for analyzing high angular resolution diffusion (HARD) imaging. Regular SHD methods have been used to characterize the features of the apparent diffusion coefficient (ADC) profile measured by the HARD technique. However, t...


    pub_type: 杂志文章


    authors: Zhan W,Stein EA,Yang Y

    更新日期:2006-02-15 00:00:00

  • Brain resting-state functional MRI connectivity: morphological foundation and plasticity.

    abstract::Despite the immense ongoing efforts to map brain functional connections and organizations with resting-state functional MRI (rsfMRI), the mechanisms governing the temporally coherent rsfMRI signals remain unclear. In particular, there is a lack of direct evidence regarding the morphological foundation and plasticity o...


    pub_type: 杂志文章


    authors: Zhou IY,Liang YX,Chan RW,Gao PP,Cheng JS,Hu Y,So KF,Wu EX

    更新日期:2014-01-01 00:00:00

  • Multi-session statistics on beamformed MEG data.

    abstract::Beamforming has been widely adopted as a source reconstruction technique in the analysis of magnetoencephalography data. Most beamforming implementations incorporate a spatially-varying rescaling (which we term weights normalisation) to correct for the inherent depth bias in raw beamformer estimates. Here, we demonstr...


    pub_type: 杂志文章


    authors: Luckhoo HT,Brookes MJ,Woolrich MW

    更新日期:2014-07-15 00:00:00

  • Single-trial EEG dynamics of object and face visual processing.

    abstract::There has been extensive work using early event-related potentials (ERPs) to study visual object processing. ERP analyses focus traditionally on mean amplitude differences, with the implicit assumption that all of the neuronal activity of interest is evoked by the stimulus in a time-locked manner from trial to trial. ...


    pub_type: 杂志文章


    authors: Rousselet GA,Husk JS,Bennett PJ,Sekuler AB

    更新日期:2007-07-01 00:00:00

  • Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI.

    abstract::Preterm birth is a major public health concern, with the severity and occurrence of adverse outcome increasing with earlier delivery. Being born preterm disrupts a time of rapid brain development: in addition to volumetric growth, the cortex folds, myelination is occurring and there are changes on the cellular level. ...


    pub_type: 杂志文章


    authors: Eaton-Rosen Z,Melbourne A,Orasanu E,Cardoso MJ,Modat M,Bainbridge A,Kendall GS,Robertson NJ,Marlow N,Ourselin S

    更新日期:2015-05-01 00:00:00

  • Assignment of functional activations to probabilistic cytoarchitectonic areas revisited.

    abstract::Probabilistic cytoarchitectonic maps in standard reference space provide a powerful tool for the analysis of structure-function relationships in the human brain. While these microstructurally defined maps have already been successfully used in the analysis of somatosensory, motor or language functions, several concept...


    pub_type: 杂志文章,评审


    authors: Eickhoff SB,Paus T,Caspers S,Grosbras MH,Evans AC,Zilles K,Amunts K

    更新日期:2007-07-01 00:00:00

  • Decoding the motion aftereffect in human visual cortex.

    abstract::In the motion aftereffect (MAE), adapting to a moving stimulus causes a subsequently presented stationary stimulus to appear to move in the opposite direction. Recently, the neural basis of the motion aftereffect has received considerable interest, and a number of brain areas have been implicated in the generation of ...


    pub_type: 杂志文章


    authors: Hogendoorn H,Verstraten FA

    更新日期:2013-11-15 00:00:00

  • Reproducibility of tract segmentation between sessions using an unsupervised modelling-based approach.

    abstract::This work describes a reproducibility analysis of scalar water diffusion parameters, measured within white matter tracts segmented using a probabilistic shape modelling method. In common with previously reported neighbourhood tractography (NT) work, the technique optimises seed point placement for fibre tracking by ma...


    pub_type: 杂志文章


    authors: Clayden JD,Storkey AJ,Muñoz Maniega S,Bastin ME

    更新日期:2009-04-01 00:00:00

  • Determining functional connectivity using fMRI data with diffusion-based anatomical weighting.

    abstract::There is strong interest in investigating both functional connectivity (FC) using functional magnetic resonance imaging (fMRI) and structural connectivity (SC) using diffusion tensor imaging (DTI). There is also emerging evidence of correspondence between functional and structural pathways within many networks (Greici...


    pub_type: 杂志文章


    authors: Bowman FD,Zhang L,Derado G,Chen S

    更新日期:2012-09-01 00:00:00

  • Artificial shifting of fMRI activation localized by volume- and surface-based analyses.

    abstract::Spatial smoothing is an important post-processing procedure that is used to increase the signal-to-noise ratio (SNR) of blood oxygenation level-dependent signals (BOLD) in common functional magnetic resonance imaging (fMRI) applications. However, recent studies have shown that smoothing artificially shifts probabilist...


    pub_type: 杂志文章


    authors: Jo HJ,Lee JM,Kim JH,Choi CH,Gu BM,Kang DH,Ku J,Kwon JS,Kim SI

    更新日期:2008-04-15 00:00:00

  • Parameter estimation in the magnitude-only and complex-valued fMRI data models.

    abstract::In functional magnetic resonance imaging, voxel time courses are complex-valued data but are traditionally converted to real magnitude-only data ones. At a large signal-to-noise ratio (SNR), the magnitude-only data Ricean distribution is approximated by a normal distribution that has been suggested as reasonable in ma...


    pub_type: 杂志文章


    authors: Rowe DB

    更新日期:2005-05-01 00:00:00

  • Brain templates and atlases.

    abstract::The core concept within the field of brain mapping is the use of a standardized, or "stereotaxic", 3D coordinate frame for data analysis and reporting of findings from neuroimaging experiments. This simple construct allows brain researchers to combine data from many subjects such that group-averaged signals, be they s...


    pub_type: 历史文章,杂志文章,评审


    authors: Evans AC,Janke AL,Collins DL,Baillet S

    更新日期:2012-08-15 00:00:00

  • Goal-independent mechanisms for free response generation: creative and pseudo-random performance share neural substrates.

    abstract::To what extent free response generation in different tasks uses common and task-specific neurocognitive processes has remained unclear. Here, we investigated overlap and differences in neural activity during musical improvisation and pseudo-random response generation. Brain activity was measured using fMRI in a group ...


    pub_type: 杂志文章


    authors: de Manzano Ö,Ullén F

    更新日期:2012-01-02 00:00:00

  • DTI of commissural fibers in patients with Chiari II-malformation.

    abstract::Chiari II-malformation is a complex congenital deformity of the brain which is frequently associated with hydrocephalus. Abnormalities of the corpus callosum are known to occur in the majority of patients. The objective of the present study was to study the microstructure of the corpus callosum (CC) and the anterior c...


    pub_type: 杂志文章


    authors: Herweh C,Akbar M,Wengenroth M,Blatow M,Mair-Walther J,Rehbein N,Nennig E,Schenk JP,Heiland S,Stippich C

    更新日期:2009-01-15 00:00:00

  • Dual-process contributions to creativity in jazz improvisations: An SPM-EEG study.

    abstract::Conflicting theories identify creativity either with frontal-lobe mediated (Type-2) executive control processes or (Type-1) associative processes that are disinhibited when executive control is relaxed. Musical (jazz) improvisation is an ecologically valid test-case to distinguish between these views because relativel...


    pub_type: 杂志文章


    authors: Rosen DS,Oh Y,Erickson B,Zhang FZ,Kim YE,Kounios J

    更新日期:2020-06-01 00:00:00

  • Event-related fMRI of the auditory cortex.

    abstract::An event-related protocol was designed to permit auditory fMRI studies minimally affected by the echo-planar noise artifact; a long time interval (TR = 10 s) between each cerebral volume acquisition was combined with stroboscopic data acquisition, and event-related curves were reconstructed with a 1-s resolution. The ...


    pub_type: 杂志文章


    authors: Belin P,Zatorre RJ,Hoge R,Evans AC,Pike B

    更新日期:1999-10-01 00:00:00

  • Fast high resolution whole brain T2* weighted imaging using echo planar imaging at 7T.

    abstract::Magnetic susceptibility based (T(2)* weighted) contrast in MRI at high magnetic field strength is of great value in research on brain structure and cortical architecture, but its use is hampered by the low signal-to-noise ratio (SNR) efficiency of the conventional spoiled gradient echo sequence (GRE) leading to long s...


    pub_type: 杂志文章


    authors: Zwanenburg JJ,Versluis MJ,Luijten PR,Petridou N

    更新日期:2011-06-15 00:00:00

  • WITHDRAWN: Neurofeedback-mediated self-regulation of the dopaminergic midbrain.

    abstract::The publisher regrets due to an error in the publishing process the above articles was accidentally withdrawn and has now been published in (Neuroimage 83C December 2013 The publisher would like to apologize for any inconvenience caused. ...


    pub_type: 杂志文章


    authors: Sulzer J,Sitaram R,Blefari ML,Kollias S,Birbaumer N,Stephan KE,Luft A,Gassert R

    更新日期:2013-07-15 00:00:00

  • Dynamic functional connectivity during task performance and rest predicts individual differences in attention across studies.

    abstract::Dynamic functional connectivity (DFC) aims to maximize resolvable information from functional brain scans by considering temporal changes in network structure. Recent work has demonstrated that static, i.e. time-invariant resting-state and task-based FC predicts individual differences in behavior, including attention....


    pub_type: 杂志文章


    authors: Fong AHC,Yoo K,Rosenberg MD,Zhang S,Li CR,Scheinost D,Constable RT,Chun MM

    更新日期:2019-03-01 00:00:00

  • Preterm birth leads to hyper-reactive cognitive control processing and poor white matter organization in adulthood.

    abstract::Individuals born preterm with very low birth weight (VLBW; birth weight ≤ 1500 g) are at high risk for perinatal brain injuries and deviant brain development, leading to increased chances of later cognitive, emotional, and behavioral problems. Here we investigated the neuronal underpinnings of both reactive and proact...


    pub_type: 杂志文章


    authors: Olsen A,Dennis EL,Evensen KAI,Husby Hollund IM,Løhaugen GCC,Thompson PM,Brubakk AM,Eikenes L,Håberg AK

    更新日期:2018-02-15 00:00:00