Abstract:
:Twenty-seven preterm infants were compared to 10 full-term infants at term equivalent age using a voxel-based analysis of diffusion tensor imaging of the brain. Preterm infants exhibited higher fractional anisotropy values, which may suggest accelerated maturation, in the location of the sagittal stratum. While some earlier findings in preterm infants have suggested developmental delays, the results of this study are more consistent with accelerated white matter development, possibly as a result of increased sensorimotor stimulation in the extrauterine environment. These results are the first to suggest that the increased intensity of stimulation associated with preterm birth may advance the process of white matter maturation in the human brain. Questions remain about whether these findings reflect acceleration of the process of white matter maturation generally, or localized alterations induced specifically by activity in affected pathways.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Giménez M,Miranda MJ,Born AP,Nagy Z,Rostrup E,Jernigan TLdoi
10.1016/j.neuroimage.2008.02.029subject
Has Abstractpub_date
2008-07-01 00:00:00pages
728-34issue
3eissn
1053-8119issn
1095-9572pii
S1053-8119(08)00161-4journal_volume
41pub_type
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