Accelerated cerebral white matter development in preterm infants: a voxel-based morphometry study with diffusion tensor MR imaging.

Abstract:

:Twenty-seven preterm infants were compared to 10 full-term infants at term equivalent age using a voxel-based analysis of diffusion tensor imaging of the brain. Preterm infants exhibited higher fractional anisotropy values, which may suggest accelerated maturation, in the location of the sagittal stratum. While some earlier findings in preterm infants have suggested developmental delays, the results of this study are more consistent with accelerated white matter development, possibly as a result of increased sensorimotor stimulation in the extrauterine environment. These results are the first to suggest that the increased intensity of stimulation associated with preterm birth may advance the process of white matter maturation in the human brain. Questions remain about whether these findings reflect acceleration of the process of white matter maturation generally, or localized alterations induced specifically by activity in affected pathways.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Giménez M,Miranda MJ,Born AP,Nagy Z,Rostrup E,Jernigan TL

doi

10.1016/j.neuroimage.2008.02.029

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

728-34

issue

3

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(08)00161-4

journal_volume

41

pub_type

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