Abnormal effective connectivity in the psychosis high-risk state.

Abstract:

:In a recently published fMRI study (Dauvermann et al., 2013), nonlinear dynamic causal modeling (DCM) was used to examine condition-specific effective connectivity in subjects at high genetic risk of schizophrenia. The authors concluded that nonlinear DCM could lead to new insights in the development of psychotic symptoms and functional and effective dysconnection at the network level in subjects at high familial risk. In this paper, we place these interesting findings in the context of recent evidence from bilinear DCM studies in subjects at high clinical risk with an at-risk mental state (ARMS) for psychosis by considering their consistency and potential differences with implications for future research in the field of emerging psychosis.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Schmidt A,Borgwardt S

doi

10.1016/j.neuroimage.2013.05.035

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

119-120

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(13)00529-6

journal_volume

81

pub_type

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