当前位置： SCI文献检索 > NEUROIMAGE期刊下所有文献 > Early detection of the chemical changes occurring during the induction and prevention of autoimmune-mediated demyelination detected by FT-IR imaging.

Early detection of the chemical changes occurring during the induction and prevention of autoimmune-mediated demyelination detected by FT-IR imaging.

Abstract：

:Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS). Despite progress in understanding immunogenetic aspects of this disease, the mechanisms involved in lesion formation are unknown. To gain new insights into the neuropathology of MS, we used an innovative integration of Fourier transform infrared (FT-IR) microspectroscopy, bioinformatics, and a synchrotron light source to analyze macromolecular changes in the CNS during the course and prevention of experimental autoimmune encephalomyelitis (EAE), an animal model for MS. We report that subtle chemical and structural changes not observed by conventional histology were detected before the onset of clinical signs of EAE. Moreover, trained artificial neural networks (ANNs) could discriminate, with excellent sensitivity and specificity, pathology from surrounding tissues and the early stage of the disease progression. Notably, we show that this novel measurement platform can detect characteristic differences in biochemical composition of lesion pathology in animals partially protected against EAE by vaccination with Nogo-A, an inhibitor of neural outgrowth, demonstrating the potential for automated screening and evaluation of new therapeutic agents.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Heraud P,Caine S,Campanale N,Karnezis T,McNaughton D,Wood BR,Tobin MJ,Bernard CC

doi

10.1016/j.neuroimage.2009.09.053

subject

Has Abstract

pub_date

2010-01-15 00:00:00

pages

1180-9

issue

2

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(09)01032-5

journal_volume

49

pub_type

杂志文章

相关文献

NEUROIMAGE文献大全
  • Resting state network estimation in individual subjects.

    abstract：:Resting state functional magnetic resonance imaging (fMRI) has been used to study brain networks associated with both normal and pathological cognitive functions. The objective of this work is to reliably compute resting state network (RSN) topography in single participants. We trained a supervised classifier (multi-l...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2013.05.108

    authors： Hacker CD,Laumann TO,Szrama NP,Baldassarre A,Snyder AZ,Leuthardt EC,Corbetta M

    更新日期：2013-11-15 00:00:00

  • Quantitative analysis of the hippocampus using images obtained from 7.0 T MRI.

    abstract：:In-vivo volumetric measurements of hippocampus have proven to be highly informative for studying various neurological diseases such as Alzheimer's disease. The usefulness of volumetric imaging, however, has been limited due to the poor image resolutions obtained by currently available MRI images. In this study, a new ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.11.002

    authors： Cho ZH,Han JY,Hwang SI,Kim DS,Kim KN,Kim NB,Kim SJ,Chi JG,Park CW,Kim YB

    更新日期：2010-02-01 00:00:00

  • Phase-amplitude coupling at the organism level: The amplitude of spontaneous alpha rhythm fluctuations varies with the phase of the infra-slow gastric basal rhythm.

    abstract：:A fundamental feature of the temporal organization of neural activity is phase-amplitude coupling between brain rhythms at different frequencies, where the amplitude of a higher frequency varies according to the phase of a lower frequency. Here, we show that this rule extends to brain-organ interactions. We measured b...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2016.08.043

    authors： Richter CG,Babo-Rebelo M,Schwartz D,Tallon-Baudry C

    更新日期：2017-02-01 00:00:00

  • Common and distinct brain regions processing multisensory bodily signals for peripersonal space and body ownership.

    abstract：:We take the feeling that our body belongs to us for granted. However, recent research has shown that it is possible to alter the subjective sensation of body ownership (BO) by manipulating multisensory bodily inputs. Several frontal and parietal regions are known to specifically process multisensory cues presented clo...

    journal_title：NeuroImage

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.neuroimage.2016.12.052

    authors： Grivaz P,Blanke O,Serino A

    更新日期：2017-02-15 00:00:00

  • Brain MAPS: an automated, accurate and robust brain extraction technique using a template library.

    abstract：:Whole brain extraction is an important pre-processing step in neuroimage analysis. Manual or semi-automated brain delineations are labour-intensive and thus not desirable in large studies, meaning that automated techniques are preferable. The accuracy and robustness of automated methods are crucial because human exper...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.12.067

    authors： Leung KK,Barnes J,Modat M,Ridgway GR,Bartlett JW,Fox NC,Ourselin S,Alzheimer's Disease Neuroimaging Initiative.

    更新日期：2011-04-01 00:00:00

  • BOLD correlates of EMG spectral density in cortical myoclonus: description of method and case report.

    abstract：:The recording of electrophysiological data during BOLD fMRI is highly challenging but provides the opportunity to develop a more thorough account of brain function than either modality alone. To develop new techniques in this area has often required the study of pathological electrophysiological measures because such ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.04.183

    authors： Richardson MP,Grosse P,Allen PJ,Turner R,Brown P

    更新日期：2006-08-15 00:00:00

  • Grasping with a new hand: Improved performance and normalized grasp-selective brain responses despite persistent functional changes in primary motor cortex and low-level sensory and motor impairments.

    abstract：:Hand loss can now be reversed through surgical transplantation years or decades after amputation. Remarkably, these patients come to use their new hand to skilfully grasp and manipulate objects. The brain mechanisms that make this possible are unknown. Here we test the hypothesis that the anterior intraparietal cortex...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.09.052

    authors： Valyear KF,Mattos D,Philip BA,Kaufman C,Frey SH

    更新日期：2019-04-15 00:00:00

  • Beta oscillations and reward processing: Coupling oscillatory activity and hemodynamic responses.

    abstract：:Diverse cortical and subcortical regions are synergically engaged during reward processing. Previous studies using time-frequency decomposition of Electroencephalography (EEG) data have revealed an increase of mid-frontal beta oscillatory activity (BOA) after reward delivery, which could be a potential mechanism in th...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.05.095

    authors： Mas-Herrero E,Ripollés P,HajiHosseini A,Rodríguez-Fornells A,Marco-Pallarés J

    更新日期：2015-10-01 00:00:00

  • Longitudinal evaluation of demyelinated lesions in a multiple sclerosis model using ultrashort echo time magnetization transfer (UTE-MT) imaging.

    abstract：:Alterations in myelin integrity are involved in many neurological disorders and demyelinating diseases, such as multiple sclerosis (MS). Although magnetic resonance imaging (MRI) is the gold standard method to diagnose and monitor MS patients, clinically available MRI protocols show limited specificity for myelin dete...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2019.116415

    authors： Guglielmetti C,Boucneau T,Cao P,Van der Linden A,Larson PEZ,Chaumeil MM

    更新日期：2020-03-01 00:00:00

  • The norepinephrine system and its relevance for multi-component behavior.

    abstract：:The ability to execute several actions in a specific temporal order to achieve an overarching goal, a process often termed action cascading or multi-component behavior, is essential for everyday life requirements. We are only at the beginning to understand the neurobiological mechanisms important for these cognitive p...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2016.10.007

    authors： Mückschel M,Gohil K,Ziemssen T,Beste C

    更新日期：2017-02-01 00:00:00

  • Neural correlates of a 'pessimistic' attitude when anticipating events of unknown emotional valence.

    abstract：:Since we do not know what future holds for us, we prepare for expected emotional events in order to deal with a pleasant or threatening environment. From an evolutionary perspective, it makes sense to be particularly prepared for the worst-case scenario. We were interested to evaluate whether this assumption is reflec...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.09.035

    authors： Herwig U,Kaffenberger T,Baumgartner T,Jäncke L

    更新日期：2007-01-15 00:00:00

  • Multifocal tDCS targeting the resting state motor network increases cortical excitability beyond traditional tDCS targeting unilateral motor cortex.

    abstract：:Scientists and clinicians have traditionally targeted single brain regions with stimulation to modulate brain function and disease. However, brain regions do not operate in isolation, but interact with other regions through networks. As such, stimulation of one region may impact and be impacted by other regions in its...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.05.060

    authors： Fischer DB,Fried PJ,Ruffini G,Ripolles O,Salvador R,Banus J,Ketchabaw WT,Santarnecchi E,Pascual-Leone A,Fox MD

    更新日期：2017-08-15 00:00:00

  • Visual cortex responses reflect temporal structure of continuous quasi-rhythmic sensory stimulation.

    abstract：:Neural processing of dynamic continuous visual input, and cognitive influences thereon, are frequently studied in paradigms employing strictly rhythmic stimulation. However, the temporal structure of natural stimuli is hardly ever fully rhythmic but possesses certain spectral bandwidths (e.g. lip movements in speech, ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2016.11.043

    authors： Keitel C,Thut G,Gross J

    更新日期：2017-02-01 00:00:00

  • Multiple foci of spatial attention in multimodal working memory.

    abstract：:The maintenance of sensory information in working memory (WM) is mediated by the attentional activation of stimulus representations that are stored in perceptual brain regions. Using event-related potentials (ERPs), we measured tactile and visual contralateral delay activity (tCDA/CDA components) in a bimodal WM task ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2016.08.019

    authors： Katus T,Eimer M

    更新日期：2016-11-15 00:00:00

  • Processing social aspects of human gaze: a combined fMRI-DTI study.

    abstract：:Human gaze is a critical social cue that can reveal intentions and dispositions of others. The right posterior superior temporal sulcus (pSTS) is thought to be critically involved in processing eye gaze information. We combined diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) to identify...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2010.11.033

    authors： Ethofer T,Gschwind M,Vuilleumier P

    更新日期：2011-03-01 00:00:00

  • Is neuroenhancement by noninvasive brain stimulation a net zero-sum proposition?

    abstract：:In the past several years, the number of studies investigating enhancement of cognitive functions through noninvasive brain stimulation (NBS) has increased considerably. NBS techniques, such as transcranial magnetic stimulation and transcranial current stimulation, seem capable of enhancing cognitive functions in pati...

    journal_title：NeuroImage

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroimage.2013.07.038

    authors： Brem AK,Fried PJ,Horvath JC,Robertson EM,Pascual-Leone A

    更新日期：2014-01-15 00:00:00

  • Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI.

    abstract：:Noninvasive localization of brain function is used to understand and treat neurological disease, exemplified by pre-operative fMRI mapping prior to neurosurgical intervention. The principal approach for generating these maps relies on brain responses evoked by a task and, despite known limitations, has dominated clini...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.09.030

    authors： Fox MD,Qian T,Madsen JR,Wang D,Li M,Ge M,Zuo HC,Groppe DM,Mehta AD,Hong B,Liu H

    更新日期：2016-01-01 00:00:00

  • Hard to wake up? The cerebral correlates of sleep inertia assessed using combined behavioral, EEG and fMRI measures.

    abstract：:The first minutes following awakening from sleep are typically marked by reduced vigilance, increased sleepiness and impaired performance, a state referred to as sleep inertia. Although the behavioral aspects of sleep inertia are well documented, its cerebral correlates remain poorly understood. The present study aime...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.09.033

    authors： Vallat R,Meunier D,Nicolas A,Ruby P

    更新日期：2019-01-01 00:00:00

  • Signal source separation in the analysis of neural activity in brain.

    abstract：:This research examines the spatial and temporal characteristics of the responses to stimulation of the barrel cortex in anesthetized rats using optical imaging with particular emphasis on methods of analysis which reduce the effects of low-frequency oscillations on localization of the activated cortical region. Image ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1006/nimg.2000.0705

    authors： Zheng Y,Johnston D,Berwick J,Mayhew J

    更新日期：2001-03-01 00:00:00

  • 10/20, 10/10, and 10/5 systems revisited: their validity as relative head-surface-based positioning systems.

    abstract：:With the advent of multi-channel EEG hardware systems and the concurrent development of topographic and tomographic signal source localization methods, the international 10/20 system, a standard system for electrode positioning with 21 electrodes, was extended to higher density electrode settings such as 10/10 and 10/...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.09.024

    authors： Jurcak V,Tsuzuki D,Dan I

    更新日期：2007-02-15 00:00:00

  • Electromagnetic responses to invisible face stimuli during binocular suppression.

    abstract：:When two incompatible monocular images compete for perceptual dominance, one can dominate awareness while the other is suppressed and invisible. It has been suggested that binocular suppression of this kind involves competitive neuronal interactions at multiple levels of the visual processing hierarchy. Here we asked ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2009.02.046

    authors： Sterzer P,Jalkanen L,Rees G

    更新日期：2009-07-01 00:00:00

  • 'Whose atlas I use, his song I sing?' - The impact of anatomical atlases on fiber tract contributions to cognitive deficits after stroke.

    abstract：:Nowadays, different anatomical atlases exist for the anatomical interpretation of the results from neuroimaging and lesion analysis studies that investigate the contribution of white matter fiber tract integrity to cognitive (dys)function. A major problem with the use of different atlases in different studies, however...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.09.051

    authors： de Haan B,Karnath HO

    更新日期：2017-12-01 00:00:00

  • Evaluation of multi-echo ICA denoising for task based fMRI studies: Block designs, rapid event-related designs, and cardiac-gated fMRI.

    abstract：:Multi-echo fMRI, particularly the multi-echo independent component analysis (ME-ICA) algorithm, has previously proven useful for increasing the sensitivity and reducing false positives for functional MRI (fMRI) based resting state connectivity studies. Less is known about its efficacy for task-based fMRI, especially a...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2016.07.049

    authors： Gonzalez-Castillo J,Panwar P,Buchanan LC,Caballero-Gaudes C,Handwerker DA,Jangraw DC,Zachariou V,Inati S,Roopchansingh V,Derbyshire JA,Bandettini PA

    更新日期：2016-11-01 00:00:00

  • Direct segmentation of the major white matter tracts in diffusion tensor images.

    abstract：:Diffusion-weighted images of the human brain are acquired more and more routinely in clinical research settings, yet segmenting and labeling white matter tracts in these images is still challenging. We present in this paper a fully automated method to extract many anatomical tracts at once on diffusion tensor images, ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.06.020

    authors： Bazin PL,Ye C,Bogovic JA,Shiee N,Reich DS,Prince JL,Pham DL

    更新日期：2011-09-15 00:00:00

  • Oxytocin receptor gene and racial ingroup bias in empathy-related brain activity.

    abstract：:The human brain responds more strongly to racial ingroup than outgroup individuals' pain. This racial ingroup bias varies across individuals and has been attributed to social experiences. What remains unknown is whether the racial ingroup bias in brain activity is associated with a genetic polymorphism. We investigate...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.01.042

    authors： Luo S,Li B,Ma Y,Zhang W,Rao Y,Han S

    更新日期：2015-04-15 00:00:00

  • Effect of task difficulty on the functional anatomy of temporal processing.

    abstract：:Temporal processing underlies many aspects of human perception, performance and cognition. The present study used fMRI to examine the functional neuroanatomy of a temporal discrimination task and to address two questions highlighted by previous studies: (1) the effect of task difficulty on neuronal activation and (2) ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.02.036

    authors： Tregellas JR,Davalos DB,Rojas DC

    更新日期：2006-08-01 00:00:00

  • Preterm birth leads to hyper-reactive cognitive control processing and poor white matter organization in adulthood.

    abstract：:Individuals born preterm with very low birth weight (VLBW; birth weight ≤ 1500 g) are at high risk for perinatal brain injuries and deviant brain development, leading to increased chances of later cognitive, emotional, and behavioral problems. Here we investigated the neuronal underpinnings of both reactive and proact...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.11.055

    authors： Olsen A,Dennis EL,Evensen KAI,Husby Hollund IM,Løhaugen GCC,Thompson PM,Brubakk AM,Eikenes L,Håberg AK

    更新日期：2018-02-15 00:00:00

  • Piecemeal recruitment of left-lateralized brain areas during reading: a spatio-functional account.

    abstract：:Neuroimaging studies of reading converge to suggest that linguistically elementary stimuli are confined to the activation of bilateral posterior regions, whereas linguistically complex stimuli additionally recruit left hemispheric anterior regions, raising the hypotheses of a gradual bilateral-to-left and a posterior-...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2008.08.008

    authors： Levy J,Pernet C,Treserras S,Boulanouar K,Berry I,Aubry F,Demonet JF,Celsis P

    更新日期：2008-11-15 00:00:00

  • Dynamics of cortical neurovascular coupling analyzed by simultaneous DC-magnetoencephalography and time-resolved near-infrared spectroscopy.

    abstract：:Functional magnetic resonance imaging (fMRI) visualizes activated brain areas with a high spatial resolution. The activation signal is determined by the local change of cerebral blood oxygenation, blood volume and blood flow which serve as surrogate marker for the neuronal signal itself. Here, the complex coupling bet...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.09.037

    authors： Mackert BM,Leistner S,Sander T,Liebert A,Wabnitz H,Burghoff M,Trahms L,Macdonald R,Curio G

    更新日期：2008-02-01 00:00:00

  • Extracting kinetic information from human motor cortical signals.

    abstract：:Brain machine interfaces (BMIs) have the potential to provide intuitive control of neuroprostheses to restore grasp to patients with paralyzed or amputated upper limbs. For these neuroprostheses to function, the ability to accurately control grasp force is critical. Grasp force can be decoded from neuronal spikes in m...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2014.07.049

    authors： Flint RD,Wang PT,Wright ZA,King CE,Krucoff MO,Schuele SU,Rosenow JM,Hsu FP,Liu CY,Lin JJ,Sazgar M,Millett DE,Shaw SJ,Nenadic Z,Do AH,Slutzky MW

    更新日期：2014-11-01 00:00:00