The integrity of the cholinergic system determines memory performance in healthy elderly.

Abstract:

:The cholinergic system plays a central role in episodic memory-related processes in health and disease. Cerebral acetylcholinesterase (AChE) activity, a measure of the integrity of the cholinergic system, can be assessed in vivo using positron emission tomography (PET) and [(11)C]N-methyl-4-piperidyl acetate (MP4A). A close relationship between the kinetic constant k3 of MP4A and mnestic functions has been demonstrated for patients suffering from amnestic mild cognitive impairment and Alzheimer's disease. Under the hypothesis that AChE activity and memory are intimately linked in older age, we obtained MP4A-PET and structural magnetic resonance images as well as neuropsychological data from fourteen healthy older adults. Multiple regression analysis revealed that AChE activity in areas previously implicated in mnestic functions predicted episodic memory performance irrespective of cortical atrophy. Data suggest that in older adults the integrity of the cholinergic system underlies inter-individual variability in memory function.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Richter N,Allendorf I,Onur OA,Kracht L,Dietlein M,Tittgemeyer M,Neumaier B,Fink GR,Kukolja J

doi

10.1016/j.neuroimage.2014.06.031

subject

Has Abstract

pub_date

2014-10-15 00:00:00

pages

481-8

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(14)00508-4

journal_volume

100

pub_type

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