Conflict monitoring mechanism at the single-neuron level in the human ventral anterior cingulate cortex.

Abstract:

:Life requires monitoring and adjusting behavior in the face of conflicts. The conflict monitoring theory implicates the anterior cingulate cortex (ACC) in these processes; its ventral aspect (vACC) specializes in emotional conflict. To elucidate the underpinning neural mechanism, we recorded vACC extracellular activity from 12 patients with mood disorders or epilepsy who performed the face-emotional Stroop task. Behaviorally, both conflict detection and adaptation to conflict were evident. The firing rate of neurons in the vACC represented current conflict, i.e., current-congruency. The late onset of the effect is compatible with a role in monitoring. Additionally, early responses of some neurons represented the immediate history of conflicts, i.e., previous-trial-congruency. Finally, in some neurons the response to the current-trial was modulated by previous-trial-congruency, laying the ground for adjusting-to-conflicts. Our results uncover a single neuron level mechanism in the vACC that encodes and integrates past and present emotional conflicts, allowing humans to accommodate their responses accordingly.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Shapira-Lichter I,Strauss I,Oren N,Gazit T,Sammartino F,Giacobbe P,Kennedy S,Hutchison WD,Fried I,Hendler T,Lozano AM

doi

10.1016/j.neuroimage.2018.03.028

subject

Has Abstract

pub_date

2018-07-15 00:00:00

pages

45-55

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(18)30238-6

journal_volume

175

pub_type

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