Promise and pitfalls of g-ratio estimation with MRI.

Abstract:

:The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for speed of signal conduction, cellular energetics, and spatial constraints. In vivo imaging of the g-ratio in health and disease would greatly increase our knowledge of the nervous system and our ability to diagnose, monitor, and treat disease. MRI based g-ratio imaging was first conceived in 2011, and expanded to be feasible in full brain white matter with preliminary results in 2013. This manuscript reviews the growing g-ratio imaging literature and speculates on future applications. It details the methodology for imaging the g-ratio with MRI, and describes the known pitfalls and challenges in doing so.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Campbell JSW,Leppert IR,Narayanan S,Boudreau M,Duval T,Cohen-Adad J,Pike GB,Stikov N

doi

10.1016/j.neuroimage.2017.08.038

subject

Has Abstract

pub_date

2018-11-15 00:00:00

pages

80-96

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(17)30685-7

journal_volume

182

pub_type

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